Results 111 to 120 of about 273,588 (361)

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

Cell Metabolism, 2017
SUMMARY Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we demonstrate that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (
Tianyi Wang, J. Fahrmann, Heehyoung Lee, Yi-jia Li, Satyendra C Tripathi, Chanyu Yue, Chunyan Zhang, Veronica Lifshitz, Jieun Song, Yuan Yuan, G. Somlo, Rahul Jandial, D. Ann, S. Hanash, R. Jove, Hua Yu   +15 more
semanticscholar   +1 more source

Amino acid similarity of IL6-STAT3-HSP90 axis related proteins between species.

, 2023
Amino acid similarity of IL6-STAT3-HSP90 axis related proteins between species.
Rui Song (331963), Xiaodong Wang (66801), Hongquan Wang (6086327), Wenzhi Liu (3997184), Zhao Lv (3122814), Qiushi Zhang (3812230), Chunhua Ding (832221), Liang Hu (202392), Junhua Li (125998), Shuting Xiong (630639), Tiaoyi Xiao (9162782), Yong-An Zhang (829491), Guoli Hou (11736683), Chun Li (57810)   +13 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Biomolecular condensates in cancer cell biology: interleukin-6-induced cytoplasmic and nuclear STAT3/PY-STAT3 condensates in hepatoma cells

, 2019
We highlight previous incompletely understood cell biology data in the STAT3 signaling field with respect to interleukin-6 (IL-6)-induced activation of this transcription factor in hepatoma cells to generate cytoplasmic and nuclear STAT3 bodies.
Pravin B. Sehgal
core   +1 more source

Table_9_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xls

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

Activation of Stat3 by cell confluence reveals negative regulation of Stat3 by cdk2 [PDF]

Oncogene, 2003
The signal transducing protein Stat3 activates gene transcription in cells in response to multiple cytokines. Constitutive activation of Stat3 has been observed in solid tumors including head and neck squamous cell carcinoma. Stat3 activation in cancer has been associated with autocrine stimulatory loops and is believed to convey a growth advantage to ...
Richard A, Steinman, Abbey, Wentzel, Yalin, Lu, Christine, Stehle, Jennifer Rubin, Grandis   +4 more
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

Cell Metabolism, 2019
SUMMARY Although obesity is known to be critical for cancer development, how obesity negatively impacts antitumor immune responses remains largely unknown.
Chunyan Zhang, Chanyu Yue, A. Herrmann, Jieun Song, C. Egelston, Tianyi Wang, Zhifang Zhang, Wenzhao Li, Heehyoung Lee, Maryam Aftabizadeh, Y. Li, Peter P. Lee, S. Forman, G. Somlo, P. Chu, L. Kruper, J. Mortimer, D. Hoon, Wendong Huang, Saul J. Priceman, Hua Yu   +20 more
semanticscholar   +1 more source

Isolation and characterization of STAT3 and PY‐STAT3 signaling endosomes

The FASEB Journal, 2006
Cytokine‐ and growth factor‐initiated STAT signaling transits from the plasma membrane to the nucleus. Until recently, STAT signaling has been viewed exclusively as a soluble cytosolic process. We have previously presented evidence for membrane‐associated STAT3 signaling through the cytoplasm [Shah et al (2005) The FASEB Journal 19, Abstract 209.9 ...
Mehul Shah, Fang Xu, Pravin Sehgal
openaire   +1 more source

STAT1 and STAT3 in tumorigenesis [PDF]

JAK-STAT, 2012
The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis. While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is considered as an oncogene, STAT1 mostly triggers anti-proliferative and pro-apoptotic responses while enhancing anti-tumor immunity. Despite being activated downstream of common
Avalle L, Pensa S., Regis G., Novelli F., and Poli   +4 more
openaire   +3 more sources