Results 1 to 10 of about 66,138 (119)

An in vitro investigation of the apoptosis-inducing activity of corosolic acid in breast cancer cells [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Breast cancer is the most prevalent cancer among females with different molecular subtypes. Corosolic acid is a pentacyclic triterpenoid with anti-cancer properties.
Saade Abdalkareem Jasim, Omer Zedan Khalaf, Shadia Hamoud Alshahrani, Kadda Hachem, Shukhrat Ziyadullaev, Abduladheem Turki Jalil, ChangMing Wang, Rahman S. Zabibah, Yousef A. Bin Jardan, Qutaiba A. Qasim, Marwah Suliman Maashi, Yasser Fakri Mustafa   +11 more
doaj   +1 more source

Serum erythropoietin in the evaluation of erythrocytosis: How much does it contribute to the diagnosis of polycythemia vera?

Journal of Applied Hematology, 2023
INTRODUCTION: Serum erythropoietin (S. EPO) continues to be a minor diagnostic criterion for discriminating polycythemia vera (PV) from other causes of erythrocytosis.
Ruchi Gupta, Manish Kumar Singh, Dinesh Chandra, Khaliqur Rahman, Ashwani Maddheshia, Akhilesh Sharma, Sanjeev Yadav, Rajesh Kashyap   +7 more
doaj   +1 more source

Overt-stage primary myelofibrosis after COVID-19 infection: a case report [PDF]

World Cancer Research Journal, 2022
OBJECTIVE: Primary Myelofibrosis (PMF) is an uncommon hematological condition where the bone marrow becomes progressively fibrotic, resulting in anemia, extramedullary hematopoiesis, and splenomegaly.
P. Darmada, N. Ustriyana, N. Kardinal, H. Saputra   +3 more
doaj   +1 more source

Clinicopathologic and Molecular Analysis of Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma: A Case Report and Review of Literature

Türk Patoloji Dergisi, 2021
Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell (FDC/FRC) sarcoma is an extremely rare neoplasm of the spleen associated with EBV and characterized by spindle cell morphology, dense mixed chronic inflammatory background, and a broad ...
Bryan MORALES-VARGAS, Kristin DEEB, Deniz PEKER   +2 more
doaj   +1 more source

Mutation Profile in BCR-ABL1-Negative Myeloproliferative Neoplasms: A Single-Center Experience From India

Hematology/Oncology and Stem Cell Therapy, 2022
Objective/Background: Recurrent somatic mutations in the JAK2, calreticulin (CALR), and the MPL genes are described as drivers of BCR-ABL1-negative myeloproliferative neoplasms (MPN) that includes polycythemia vera (PV), essential thrombocytosis (ET ...
Madhavi Maddali, Uday Prakash Kulkarni, Niveditha Ravindra, Arun Kumar Arunachalam, Arvind Venkatraman, Sharon Lionel, Marie Therese Manipadam, Anup J. Devasia, Anu Korula, N.A. Fouzia, Aby Abraham, Alok Srivastava, Biju George, Poonkuzhali Balasubramanian, Vikram Mathews   +14 more
doaj   +1 more source

Effect of leptin on the growth and expression of STAT3 in yak mammary epithelial cells [PDF]

Veterinary World, 2022
Background and Aim: Leptin (LEP) is an autocrine and paracrine factor produced by the fat pad and acinar epithelial cells of the breast. This study aimed to investigate the effects of LEP on yak mammary epithelial cells (YMECs) and the expression of ...
Baoxia Dong, Sidra Mehran, Yuying Yang, Haixia Jing, Lin Liang, Xiaoyu Guo, Qinwen Zhang   +6 more
doaj   +1 more source

JAK2/STAT5 Pathway Mutation Frequencies in South African BCR/ABL Negative MPN Patients

Hematology/Oncology and Stem Cell Therapy, 2023
Background: Mutations in JAK2/STAT5 proliferation pathway genes are key in the diagnosis of myeloproliferative neoplasms (MPNBCR/ABLneg), with JAK2V617F being found in 50-97% of MPNBCR/ABLneg subtypes.
Karen L. Shires, Adriana J. Rust, Rushil Harryparsad, Justin A. Coburn, Ruth E. Gopie   +4 more
doaj   +1 more source

Efficiency of interferon therapy in patients with essential thrombocythemia or polycythemia vera [PDF]

Терапевтический архив, 2016
Aim. To evaluate the efficiency of interferon (IFN) therapy in patients with essential thrombocythemia (ET) and polycythemia vera (PV). Subjects and methods. A total of 61 patients (41 with ET and 20 with PV) were examined.
M A Sokolova, A G Turkina, A L Melikian, A B Sudarikov, S A Treglazova, O A Shukhov, E G Gemdzhian, A О Abdullaev, A M Kovrigina, A V Misyurin, Yu V Pliskunova, V L Ivanova, T N Moiseeva   +12 more
doaj   +1 more source

Detection of activating mutations in RAS/RAF/MEK/ERK and JAK/STAT signaling pathways [PDF]

Терапевтический архив, 2020
Issue.The study of activating mutations (NRAS,KRAS,FLT3,JAK2,CRLF2genes) of RAS/RAF/MEK/ERK and JAK/STAT signaling pathways in B-cell acute lymphoblastic leukemia (B-ALL) in adult patients which are included in Russian multicenter clinical trials ...
K. I. Zarubina, E. N. Parovichnikova, V. L. Surin, O. S. Pshenichnikova, O. A. Gavrilina, G. A. Isinova, V. V. Troitskaia, A. N. Sokolov, I. V. Gal’tseva, N. M. Kapranov, Iu. O. Davydova, T. N. Obukhova, A. B. Sudarikov, V. G. Savchenko   +13 more
doaj   +1 more source

Mouse models of myeloproliferative neoplasms for pre-clinical testing of novel therapeutic agents

Biomedical Papers, 2021
Myeloproliferative neoplasms (MPN), are clonal hematopoietic stem cell (HSC) disorders driven by gain-of-function mutations in JAK2 (JAK2-V617F), CALR or MPL genes.
Jan Stetka, Radek C. Skoda
doaj   +1 more source