Results 41 to 50 of about 79,208 (292)
JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease
Gazi Medical JournalObjective: Behçet’s disease (BD) is a chronic, multisystemic inflammatory disorder with an unknown etiology. T cells are crucial in the pathogenesis of BD.
Darya Farhoomand Aksoy +3 more
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Simultaneous hepatosplenic T-cell lymphoma and myelofibrosis
Avicenna Journal of Medicine, 2014 Hepatosplenic T-cell lymphoma (HSTL) is a rare T-cell neoplasm of the lymphoid system. This type of lymphoma is characterized by sinusoidal infiltration of spleen, liver, bone marrow and lymph nodes by neoplastic lymphocytes.
Ali M Gabali +4 more
doaj +1 more source
Myelofibrosis, JAK2 inhibitors and erythropoiesis [PDF]
Leukemia, 2013 The term myeloproliferative disorders was introduced by William Dameshek1 in 1951 to describe four different diseases with a related pathogenesis: polycythaemia vera (PV), essential thrombocythaemia (ET), primary myelofibrosis (PMF) and chronic myeloid leukaemia. The discovery of the Philadelphia chromosome and the fusion gene BCR-ABL has permitted the
W, Vainchenker, F, Favale
openaire +2 more sources
Drugs in Context, 2020 The Janus kinases (JAK) are a group of molecules, composed of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2), which are key components within the JAK–signal transducers and activators of transcription pathway, where cytokine receptor signaling takes ...
Novin Nezamololama +3 more
doaj +1 more source
Iraqi Journal of Hematology, 2020 BACKGROUND: Chronic inflammation has been suggested to contribute to the pathogenesis of thrombosis in polycythemia vera (PV) as it triggers in vivo activation of platelets, leukocytes, and endothelial cells, which are all of major importance during ...
Ibrahim Abdullah Mahmood +2 more
doaj +1 more source
Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders [PDF]
, 2009 The myeloproliferative disorders (MPDs) are a group of haematopoietic stem cell diseases, characterised by proliferation of one or more cells of the myeloid lineage.
Hidalgo-Curtis, Claire
core +1 more source
PLoS ONE, 2022 JAK2 is cytokine-activated non-receptor tyrosine kinase. Although JAK2 is mainly localized at the plasma membrane, it is also present on the centrosome. In this study, we demonstrated that JAK2 localization to the centrosome depends on the SH2 domain and
Aashirwad Shahi +3 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele. [PDF]
PLoS ONE, 2013 Utilizing ENU mutagenesis, we identified a mutant mouse with elevated platelets. Genetic mapping localized the mutation to an interval on chromosome 19 that encodes the Jak2 tyrosine kinase.
Nicole M Anderson +16 more
doaj +1 more source
Myeloproliferative neoplasms and JAK2 mutations [PDF]
Tidsskrift for Den norske legeforening, 2016 The relationship between the JAK2V617F mutation and myeloproliferative neoplasms was described in 2005, and has since paved the way for a new understanding of these diseases. The purpose of the study was to determine the prevalence of JAK2V617F in a Norwegian patient cohort assessed for myeloproliferative neoplasia, and to investigate potential ...
Håkon Reikvam +5 more
openaire +2 more sources