Results 1 to 10 of about 24,077 (195)
Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders [PDF]
Cells, 2021 Platelets are conventionally defined as playing a vital role in homeostasis and thrombosis. This role has over the years transformed as knowledge regarding platelets has expanded to include inflammation, cancer progression, and metastasis.
Lisa Repsold, Anna Margaretha Joubert
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Chorea and Cognitive Impairment in JAK2V617F-Positive Myeloproliferative Disorders: A Case Report and Literature Review [PDF]
Medicina, 2023 Chorea is a hyperkinetic movement disorder, accompanied by dystonia, myoclonus, tics, stereotypies, and tremors. It is characterized by excessive, purposeless movements that are distressing, irregularly timed, and randomly distributed.
Ioana Butnariu +7 more
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A review of current knowledge of myeloproliferative disorders in the horse [PDF]
Acta Veterinaria Scandinavica, 2021 Myeloid disorders are conditions being characterized by abnormal proliferation and development of myeloid lineage including granulocytes (neutrophils, eosinophils and basophils), monocytes, erythroids, and megakaryocytes precursor cells. Myeloid leukemia,
Katy Satué +2 more
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Pathogenesis of Myeloproliferative Disorders [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2016 Myeloproliferative neoplasms (MPNs) are a set of chronic hematopoietic neoplasms with overlapping clinical and molecular features. Recent years have witnessed considerable advances in our understanding of their pathogenetic basis. Due to their protracted clinical course, the evolution to advanced hematological malignancies, and the accessibility of ...
Jyoti Nangalia +2 more
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Hereditary myeloproliferative disorders
Haematologica, 2010 Hereditary forms of myeloproliferative disorders (MPD) can be divided into two broad categories. First, inherited syndromes that affect a single lineage with Mendelian inheritance, high penetrance and polyclonal hematopoiesis, and second, inherited predisposition to true MPD, characterized by ...
Radek C. Skoda
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Eosinophilic myeloproliferative disorders. [PDF]
Hematology Am Soc Hematol Educ Program, 2011 AbstractDespite recent attempts to define and classify patients with marked eosinophilia and features consistent with myeloproliferative disease, areas of controversy remain. These are particularly apparent in situations in which multiple lineages are involved in a clonal process and clinical manifestations are overlapping. Although the introduction of
Klion AD.
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Blood, 2008 Abstract In 1951 William Dameshek classified polycythemia vera (PV), essential thombocytosis (ET), and primary myelofibrosis (PMF) as pathogenetically related myeloproliferative disorders (MPD). Subsequent studies demonstrated that PV, ET, and PMF are clonal disorders of multipotent hematopoietic progenitors.
Ross L, Levine, D Gary, Gilliland
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IL-4 Serum Level Estimation in Myeloproliferative Neoplasm Patients
مجلة مركز بحوث التقنيات الاحيائية, 2022 Back Ground: Myeloproliferative neoplasm (MPN) is a long-term blood disease that has an excess production of mature hematopoietic pluripotent stem cells in the bone marrow. In the early fifties, W.
Ahmed Rushdi Abdullah
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The Thrombopoietin Receptor, MPL, Is a Therapeutic Target of Opportunity in the MPN
Frontiers in Oncology, 2021 The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis share driver mutations that either activate the thrombopoietin receptor, MPL, or indirectly activate it through mutations in the gene for JAK2, its ...
Jerry L. Spivak, Alison R. Moliterno
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Molecular Genetics & Genomic Medicine, 2022 The JAK2 gene encodes for a non‐receptor tyrosine kinase that plays a key role in the JAK/STAT signaling transfer pathway. Genetic polymorphisms of this gene have been indicated to be associated with myeloproliferative neoplasm‐associated thrombosis in ...
Nguyen Thy Ngoc +3 more
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