Results 41 to 50 of about 24,077 (195)

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Advanced Lung Cancer Inflammation Index as a Prognostic Inflammation–Nutrition Marker in Appendiceal High‐Grade Pseudomyxoma Peritonei: A 10‐Year Single‐Center Study

ANZ Journal of Surgery, EarlyView.
Among 223 patients with appendiceal high‐grade pseudomyxoma peritonei, a high advanced lung cancer inflammation index (ALI) was independently associated with improved overall survival. A nomogram integrating ALI with clinicopathological and surgical factors showed good discrimination, calibration, and clinical utility for predicting 1‐, 2‐, and 3‐year ...
Yun Gao, Ruiqing Ma, Zhenhai Feng, Siyi Yang, Guangyu An   +4 more
wiley   +1 more source

New molecular markers of CML progression

Клиническая онкогематология, 2014
In the contrast to Ph’-negative chronic myeloproliferative disorders (cMPD), chronic myelogenous leukemia (CML) is prone to rather early transformation into the later stage disease, known as the acceleration phase (AP) and blast crisis (BC ...
V. A. Misyurin, A. V. Misyurin, L. A. Kesayeva, Yu. P. Finashutina, Ye. N. Misyurina, I. N. Soldatova, A. A. Krutov, N. A. Lyzhko, T. V. Akhlynina, A. Ye. Lukina, T. I. Kolosheynova, N. V. Novitskaya, Ye. G. Arshanskaya, Ye. G. Ovsyannikova, R. A. Golubenko, V. A. Lapin, T. I. Pospelova, V. A. Tumakov, A. Yu. Baryshnikov   +18 more
doaj   +1 more source

Atypical pyoderma gangrenosum in a patient with osteomyelofibrosis [PDF]

Vojnosanitetski Pregled, 2007
Background. Atypical forms of pyoderma gangrenosum generally appear on the upper extremities; most frequently they are associated with myeloproliferative disorders, including osteomyelofibrosis.
Živanović Dubravka, Tanasilović Srđan, Škiljević Dušan, Tomović Maja, Bogdanović Andrija, Vesić Sonja, Medenica Ljiljana   +6 more
doaj   +1 more source

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, EarlyView.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Concomitant BCR-ABL1 positive chronic myelogenous leukemia emerging in a patient with MPL W515L associated primary myelofibrosis

Human Pathology: Case Reports, 2016
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more cell lineages in the bone marrow.
Juan C. Gomez-Gelvez, MD, Elena Ivan, MD, Bryan L. Betz, PhD, Megan S. Lim, MD, PhD   +3 more
doaj   +1 more source

Hyperglycaemia as a predictor of morbidity and mortality in patients receiving an allogeneic haematopoietic stem cell transplantation

British Journal of Haematology, EarlyView.
Summary Allogeneic haematopoietic stem cell transplantation (allo‐HSCT) is an effective treatment for patients with haematological malignancies; however, post‐transplant complications, including infections and acute graft‐versus‐host disease (aGvHD), remain significant issues. Identifying modifiable risk factors is therefore critical to improve patient
Marieke Tienstra, Fleur R. Goemans, Kylie Keijzer, Inge V. G. Oteman, Carin L. E. Hazenberg, Jaap A. van Doesum, Anne G. H. Niezink, Goda Choi, Gerwin A. Huls, Peter R. van Dijk, Hilde A. M. Kooistra, Tom van Meerten, Linde M. Morsink   +12 more
wiley   +1 more source

Comorbid conditions after allogeneic haematopoietic stem cell transplantation in young adults in Germany—A prospective, multicentre trial

British Journal of Haematology, EarlyView.
Summary Young adults (YA) are particularly affected by comorbid conditions following allogeneic haematopoietic stem cell transplantation (alloHSCT), as they have to live with them for many years. This is the first multicentre prospective study investigating sequelae after alloHSCT in YA in Germany. In total, 107 patients who survived relapse‐free until
Pauline Rocke, Lena Tandetzky, Daniel Wolff, Katharina Egger‐Heidrich, Daniela Heidenreich, Kerstin Schaefer‐Eckart, Eva Wagner‐Drouet, Jochen J. Frietsch, Andreas Hochhaus, Inken Hilgendorf   +9 more
wiley   +1 more source

Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera.

PLoS ONE, 2020
The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver mutations that either directly activate the thrombopoietin receptor, MPL, or activate it ...
Jerry L Spivak, Akil Merchant, Donna M Williams, Ophelia Rogers, Wanke Zhao, Amy Duffield, Linda S Resar, Alison R Moliterno, Zhizhuang J Zhao   +8 more
doaj   +1 more source