Results 11 to 20 of about 73,607 (303)

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias [PDF]

Genes & Development, 2018
Activating JAK2 point mutations are implicated in the pathogenesis of myeloid and lymphoid malignancies, including high-risk B-cell acute lymphoblastic leukemia (B-ALL). In preclinical studies, treatment of JAK2 mutant leukemias with type I JAK2 inhibitors (e.g., Food and Drug Administration [FDA]-approved ruxolitinib) provided limited single-agent ...
Kim, S-K, Knight, DA, Jones, LR, Vervoort, S, Ng, AP, Seymour, JF, Bradner, JE, Waibel, M, Kats, L, Johnstone, RW   +9 more
core   +5 more sources

Recurrent numerical aberrations of JAK2 and deregulation of the JAK2-STAT cascade in lymphomas [PDF]

Modern Pathology, 2009
The Janus kinase 2 (JAK2)-signal transducers and activators of transcription (STAT) pathway plays an important role in hematological malignancies. Mutations and translocations of the JAK2 gene, mapped at 9p24, lead to constitutive activation of JAK2 and its downstream targets.
Meier, Cecile, Hoeller, Sylvia, Bourgau, Caroline, Hirschmann, Petra, Schwaller, Juerg, Went, Philip, Pileri, Stefano A., Reiter, Andreas, Dirnhofer, Stephan, Tzankov, Alexandar   +9 more
openaire   +5 more sources

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors [PDF]

Cell Reports, 2013
To design rational therapies for JAK2-driven hematological malignancies, we functionally dissected the key survival pathways downstream of hyperactive JAK2.
Michaela Waibel, Vanessa S. Solomon, Deborah A. Knight, Rachael A. Ralli, Sang-Kyu Kim, Kellie-Marie Banks, Eva Vidacs, Clemence Virely, Keith C.S. Sia, Lauryn S. Bracken, Racquel Collins-Underwood, Christina Drenberg, Laura B. Ramsey, Sara C. Meyer, Megumi Takiguchi, Ross A. Dickins, Ross Levine, Jacques Ghysdael, Mark A. Dawson, Richard B. Lock, Charles G. Mullighan, Ricky W. Johnstone   +21 more
doaj   +2 more sources

JAK2 Negative Polycythemia Vera

Journal of Laboratory Physicians, 2010
ABSTRACTPolycythemia vera (PV) is a stem cell disorder, characterized as a panhyperplastic, malignant, and neoplastic marrow disorder. Several reasons suggest that a mutation on the Janus kinase-2 gene (JAK2) is the most probable candidate gene involved in PV pathogenesis, as JAK2 is directly involved in intracellular signaling, following its exposure ...
Geetha, J P, Arathi, C A, Shalini, M, Srinivasa Murthy, A G   +3 more
openaire   +3 more sources

Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction

Scientific Reports, 2017
JAK2 activation is crucial for cytokine receptor signal transduction and leukemogenesis. However, the underlying processes that lead to full activation of JAK2 are unclear.
Chun-Shan Liu, Hsin-Fang Yang-Yen, Ching-Shu Suen, Ming-Jing Hwang, Jeffrey Jong-Young Yen   +4 more
doaj   +2 more sources

JAK2 Mutation Assessment in Thrombotic Events at Unusual Anatomical Sites: Insights from a High-Altitude Cohort

International Journal of General Medicine
Husain Yahya Alkhaldy,1 Ayel Omar Yahya,2 Abdullah Mohammed Algarni,3 Omayma SE Bakheet,4 Mohammed Assiri,3 M Saboor5,6 1Department of Internal Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia; 2Division of Adult Hematology, King
Alkhaldy HY, Yahya AO, Algarni AM, Bakheet OSE, Assiri M, Saboor M   +5 more
doaj   +2 more sources

An in vitro investigation of the apoptosis-inducing activity of corosolic acid in breast cancer cells [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Breast cancer is the most prevalent cancer among females with different molecular subtypes. Corosolic acid is a pentacyclic triterpenoid with anti-cancer properties.
Saade Abdalkareem Jasim, Omer Zedan Khalaf, Shadia Hamoud Alshahrani, Kadda Hachem, Shukhrat Ziyadullaev, Abduladheem Turki Jalil, ChangMing Wang, Rahman S. Zabibah, Yousef A. Bin Jardan, Qutaiba A. Qasim, Marwah Suliman Maashi, Yasser Fakri Mustafa   +11 more
doaj   +1 more source

Serum erythropoietin in the evaluation of erythrocytosis: How much does it contribute to the diagnosis of polycythemia vera?

Journal of Applied Hematology, 2023
INTRODUCTION: Serum erythropoietin (S. EPO) continues to be a minor diagnostic criterion for discriminating polycythemia vera (PV) from other causes of erythrocytosis.
Ruchi Gupta, Manish Kumar Singh, Dinesh Chandra, Khaliqur Rahman, Ashwani Maddheshia, Akhilesh Sharma, Sanjeev Yadav, Rajesh Kashyap   +7 more
doaj   +1 more source

Overt-stage primary myelofibrosis after COVID-19 infection: a case report [PDF]

World Cancer Research Journal, 2022
OBJECTIVE: Primary Myelofibrosis (PMF) is an uncommon hematological condition where the bone marrow becomes progressively fibrotic, resulting in anemia, extramedullary hematopoiesis, and splenomegaly.
P. Darmada, N. Ustriyana, N. Kardinal, H. Saputra   +3 more
doaj   +1 more source

Clinicopathologic and Molecular Analysis of Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma: A Case Report and Review of Literature

Türk Patoloji Dergisi, 2021
Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell (FDC/FRC) sarcoma is an extremely rare neoplasm of the spleen associated with EBV and characterized by spindle cell morphology, dense mixed chronic inflammatory background, and a broad ...
Bryan MORALES-VARGAS, Kristin DEEB, Deniz PEKER   +2 more
doaj   +1 more source