Results 1 to 10 of about 9,905 (116)

CALR-dependent endoplasmic reticulum N-glycoprotein maturation promotes Japanese encephalitis virus entry and replication [PDF]

Cell & Bioscience
The endoplasmic reticulum (ER) chaperone machinery participates in multiple stages of viral infection, from entry through assembly and release. However, how ER-resident quality-control mechanisms shape cellular permissiveness to Japanese encephalitis ...
Yonghui Zhang, Jinyan Zhang, Rui Jiang, Jingpei Han, Hailong Liu, Yuan Wang, Liuxing Qin, Zishi Guo, Yuqing Yang, Jinxue Ruan, Xinyun Li, Xiangmin Li, Kun Han, Ping Qian, Shengsong Xie   +14 more
doaj   +2 more sources

Differential regulation of mTORC2 signalling by type I and type II calreticulin (CALR) driver mutations of myeloproliferative neoplasm

Cell Communication and Signaling
Calreticulin (CALR) is an endoplasmic reticulum chaperone. Frameshift mutations in CALR were discovered in patients with myeloproliferative neoplasm showing increased platelet counts.
Saurabh Shrivastva, Anita Roy, Chinmoy Sankar Dey   +2 more
exaly   +2 more sources

Transcriptional regulation of cpsQ-mfpABC and mfpABC by CalR in Vibrio parahaemolyticus

MicrobiologyOpen, 2017
The cpsQ‐mfpABC locus is transcribed as two operons, i.e., cpsQ‐mfpABC and mfpABC, in Vibrio parahaemolyticus, and both of them are all required for biofilm formation.
George Osei-Adjei, Huiying Yang, Dongsheng Zhou   +2 more
exaly   +2 more sources

Response to therapy and prognosis according to molecular characterization in CALR‐mutated essential thrombocythemia [PDF]

HemaSphere
Response to cytoreductive therapy according to CALR mutation type, CALR variant allele frequency (VAF), and additional mutations has not been previously studied in essential thrombocythemia (ET).
Marta Santaliestra, Marta Garrote, María Concepción Fernández‐Rodríguez, Patricia Vélez, Alicia Senín, Eduardo Arellano‐Rodrigo, Neus Garcia‐Gisbert, Raquel Longarón, Manuel Pérez‐Encinas, Gonzalo Caballero‐Navarro, Maria Soledad Noya‐Pereira, Beatriz Cuevas, María Teresa Gómez‐Casares, Ruth Stuckey, Gonzalo Carreño‐Tarragona, Francisca Ferrer‐Marin, Miguel Angel Cortés, Elena Magro, Isabel Mata, Anna Angona, Raúl Pérez, María Laura Fox, Irene Pastor‐Galán, Paula Sastre, Ana Triguero, Valentín García‐Gutierrez, Juan Carlos Hernández‐Boluda, Beatriz Bellosillo, Alberto Alvarez‐Larran   +28 more
doaj   +2 more sources

Mutation Profile in BCR-ABL1-Negative Myeloproliferative Neoplasms: A Single-Center Experience From India

Hematology/Oncology and Stem Cell Therapy, 2022
Objective/Background: Recurrent somatic mutations in the JAK2, calreticulin (CALR), and the MPL genes are described as drivers of BCR-ABL1-negative myeloproliferative neoplasms (MPN) that includes polycythemia vera (PV), essential thrombocytosis (ET ...
Madhavi Maddali, Uday Prakash Kulkarni, Niveditha Ravindra, Arun Kumar Arunachalam, Arvind Venkatraman, Sharon Lionel, Marie Therese Manipadam, Anup J. Devasia, Anu Korula, N.A. Fouzia, Aby Abraham, Alok Srivastava, Biju George, Poonkuzhali Balasubramanian, Vikram Mathews   +14 more
doaj   +1 more source

Calreticulin as a prognostic biomarker and correlated with immune infiltrate in kidney renal clear cell carcinoma

Frontiers in Genetics, 2022
Background: Calreticulin (CALR) has been investigated in several malignant diseases and is associated with immune-cell infiltration. However, the prognostic value of CALR in kidney renal clear cell carcinoma (KIRC) is still unknown.Methods: Based on the ...
Ming Sun, Shanshan Qi, Min Wu, Wei Xia, Hao Xiong   +4 more
doaj   +1 more source

High-throughput drug screening identifies the ATR-CHK1 pathway as a therapeutic vulnerability of CALR mutated hematopoietic cells

Blood Cancer Journal, 2021
Mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia and primary myelofibrosis. To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we searched for small ...
Ruochen Jia, Leon Kutzner, Anna Koren, Kathrin Runggatscher, Peter Májek, André C. Müller, Michael Schuster, Christoph Bock, Joanna I. Loizou, Stefan Kubicek, Robert Kralovics   +10 more
doaj   +1 more source

Bioinformatics analysis for the role of CALR in human cancers.

PLoS ONE, 2021
Cancer is one of the most important public health problems in the world. The curative effect of traditional surgery, radiotherapy and chemotherapy is limited and has inevitable side effects.
Yijun Li, Xiaoxu Liu, Heyan Chen, Peiling Xie, Rulan Ma, Jianjun He, Huimin Zhang   +6 more
doaj   +1 more source

Doxycycline Induces Apoptosis of Brucella Suis S2 Strain-Infected HMC3 Microglial Cells by Activating Calreticulin-Dependent JNK/p53 Signaling Pathway

Frontiers in Cellular and Infection Microbiology, 2021
Neurobrucellosis is a chronic complication of human brucellosis that is caused by the presence of Brucella spp in the central nervous system (CNS) and the inflammation play a key role on the pathogenesis.
Zhao Wang, Yanbai Wang, Huan Yang, Jiayu Guo, Zhenhai Wang, Zhenhai Wang   +5 more
doaj   +1 more source

Myeloproliferative neoplasm-driving Calr frameshift promotes the development of pulmonary hypertension in mice

Journal of Hematology & Oncology, 2021
Frameshifts in the Calreticulin (CALR) exon 9 provide a recurrent driver mutation of essential thrombocythemia (ET) and primary myelofibrosis among myeloproliferative neoplasms (MPNs).
Keiji Minakawa, Tetsuro Yokokawa, Koki Ueda, Osamu Nakajima, Tomofumi Misaka, Yusuke Kimishima, Kento Wada, Yusuke Tomita, Saori Miura, Yuka Sato, Kosaku Mimura, Koichi Sugimoto, Kazuhiko Nakazato, Kenneth E. Nollet, Kazuei Ogawa, Takayuki Ikezoe, Yuko Hashimoto, Yasuchika Takeishi, Kazuhiko Ikeda   +18 more
doaj   +1 more source