Results 31 to 40 of about 12,091 (231)
Protein-protein interaction network of CALR.
, 2021 (a)The top 21 proteins associated with CALR based on the STRING database. (b)The interacted genes with CALR according to the GeneMANIA website.
Jianjun He (104318) +6 more
core +1 more source
, 2023 Current river assessment methods focus on evaluating a single aspect (e.g. the physical and chemical quality of the water or its hydromorphological state) and usually do not integrate various factors.
Daniel Liberacki (14769057) +3 more
core +1 more source
Targeting the CALR interactome in myeloproliferative neoplasms [PDF]
JCI Insight, 2018 Mutations in the ER chaperone calreticulin (CALR) are common in myeloproliferative neoplasm (MPN) patients, activate the thrombopoietin receptor (MPL), and mediate constitutive JAK/STAT signaling. The mechanisms by which CALR mutations cause myeloid transformation are incompletely defined. We
Elodie Pronier +13 more
openaire +2 more sources
Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis
OncoImmunology, 2020 Increased exposure of calreticulin (CALR) on malignant cells is associated with therapy-relevant adaptive immune responses and superior therapeutic outcome in solid tumors and haemato-oncological diseases, because surface-exposed CALR acts as an ‘eat-me’
Oliver Kepp +4 more
doaj +1 more source
PLoS ONE, 2022 Aim to investigate the effect of miR-206 on the growth and metastasis of breast cancer stem cells and clarify the precise mechanism of miR-206 on EVI-1-mediated CALR expression in driving malignant phenotype.
Dapeng Sun +2 more
doaj +1 more source
Клиническая онкогематологияThe development of National clinical guidelines on diagnosis and treatment of Ph-negative myeloproliferative neoplasms provides the knowledge basis for decision making in diagnosis, therapy, prevention, and rehabilitation in compliance with evidence ...
Anait Levonovna Melikyan +22 more
doaj +1 more source
Role of the Unfolded Protein Response in Type I CALR-Mutant Myeloproliferative Neoplasms [PDF]
, 2023 Approximately 20% of patients with myeloproliferative neoplasms (MPNs) harbor mutations in the gene calreticulin (CALR), with 80% of those mutations classified as either type 1 or type 2. Current targeted therapies for CALR mutated MPNs are not curative,
Ibarra, Juan M.
core +1 more source
The CALR exon 9 mutations are shared neoantigens in patients with CALR mutant chronic myeloproliferative neoplasms [PDF]
Leukemia, 2016 The CALR exon 9 mutations are shared neoantigens in patients with CALR mutant chronic myeloproliferative ...
Holmström, Morten Orebo +4 more
openaire +3 more sources
Rapid and sensitive detection of CALR exon 9 mutations using high-resolution melting analysis
, 2017 Background: Somatic CALR exon 9 mutations have recently been identified in patients with JAK2/MPL-unmutated myeloproliferative neoplasm, and have become an important clonal marker for the diagnosis of essential thrombocythemia (ET) and primary ...
郭遠燁;周文堅 +1 more
core +1 more source
Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development [PDF]
, 2019 Frameshifting mutations (−1/+2) of the calreticulin (CALR) gene are responsible for the development of essential thrombocythemia (ET) and primary myelofibrosis (PMF).
Achouri, Younes +28 more
core +1 more source