Results 41 to 50 of about 12,091 (231)

CALR mutation types in tumors (COSMIC).

, 2021
CALR mutation types in tumors (COSMIC).
Jianjun He (104318), Rulan Ma (9959879), Heyan Chen (9666599), Peiling Xie (6665915), Huimin Zhang (1428787), Yijun Li (388000), Xiaoxu Liu (2558449)   +6 more
core   +1 more source

Loss of KDEL function from a calreticulin frameshift mutation drives expression of an immature, mutant calreticulin-dependent form of the thrombopoietin receptor MPL

Haematologica
Mutant calreticulin (CALR) activates the thrombopoietin (TPO) receptor MPL, thereby inducing the development of essential thrombocythemia and primary myelofibrosis.
Nami Masubuchi, Yinjie Yang, Misa Imai, Yoshihiko Kihara, Soji Morishita, Yoko Edahiro, Norio Komatsu   +6 more
doaj   +1 more source

Clinical Manifestation of Calreticulin Gene Mutations in Essential Thrombocythemia without Janus Kinase 2 and MPL Mutations: A Chinese Cohort Clinical Study

Chinese Medical Journal, 2016
Background: Recently, calreticulin (CALR) gene mutations have been identified in patients with essential thrombocythemia (ET). A high-frequency of ET cases without Janus kinase 2 (JAK2) mutations contain CALR mutations and exhibit clinical ...
Chao Sun, Xin Zhou, Zhi-Jian Zou, Hong-Feng Guo, Jian-Yong Li, Chun Qiao   +5 more
doaj   +1 more source

Calreticulin enhances gastric cancer metastasis by dimethylating H3K9 in the E-cadherin promoter region mediating by G9a

Oncogenesis, 2022
The latest study shows that gastric cancer (GC) ranked the fifth most common cancer (5.6%) with over 1 million estimated new cases annually and the fourth most common cause of cancer death (7.7%) globally in 2020.
Lina Wang, Jun Chen, Qianfei Zuo, Chunmei Wu, Ting Yu, Pengfei Zheng, Hui Huang, Jun Deng, Lichao Fang, Huamin Liu, Chenghong Li, Peiwu Yu, Quanming Zou, Junsong Zheng   +13 more
doaj   +1 more source

Coexistence of JAK2 and CALR mutations and their clinical implications in patients with essential thrombocythemia

, 2022
S.57036-57049Janus kinase 2 (JAK2) and calreticulin (CALR) constitute the two most frequent mutations in essential thrombocythemia (ET), and both are reported to be mutually exclusive.
Choi, Yong Jun, Szardenings, Michael, Kim, Hye-Ran, Lee, Jun Hyung, Suh, Soon-Pal, Shin, Jong Hee, Kang, Min-Gu, Shin, Myung Geun, Choi, Hyun-Jung, Choi, Hyun-Woo   +9 more
core   +1 more source

Mutated CALR: tails from the crypt [PDF]

Blood, 2019
The discovery by exome sequencing that calreticulin ( CALR ) gene mutations are important gain-of-function myeloproliferative neoplasm (MPN) driver mutations 1,2 was as inexplicable as it was unexpected. In this issue of Blood , Pecquet et al 3 report that mutated CALR behaves like a rogue chaperone, usurping the role of JAK2 and promiscuously ...
openaire   +2 more sources

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Mutant Calreticulin in the Myeloproliferative Neoplasms

HemaSphere, 2020
. Mutations in the gene for calreticulin (CALR) were identified in the myeloproliferative neoplasms (MPNs) essential thrombocythaemia (ET) and primary myelofibrosis (MF) in 2013; in combination with previously described mutations in JAK2 and MPL, driver ...
Daniel Prins, Carlos González Arias, Thorsten Klampfl, Jacob Grinfeld, Anthony R. Green   +4 more
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

USE OF DNA ISOLATED FROM BONE MARROW SAMPLES IN PARAFFIN BLOCKS FROM PATIENTS WITH MPN TO ANALYZE SOMATIC MUTATIONS

Siberian Journal of Life Sciences and Agriculture, 2019
Myeloproliferative neoplasms (MPN) are a clonal disease characterized by impaired proliferation of myelopoietic cell lines. WHO recommends molecular genetic studies to confirm the diagnosis and determine the phenotypic form.
Dmitry Vladimirovich Kurochkin, Anastasia Aleksandrovna Karnyushka, Tatyana Yuryevna Petrichenko, Tatiana Nikolaevna Subbotina, Tatyana Andreevna Garkusha, Anna Sergeevna Khazieva, Vladimir Alekseevich Khorzhevsky   +6 more
doaj   +1 more source