Results 51 to 60 of about 12,091 (231)
Hematology, 2022 Objective Calreticulin (CALR) mutations have been identified as driver mutations in a quarter of patients with essential thrombocythaemia (ET) and primary myelofibrosis (PMF), which are subgroups of myeloproliferative neoplasms (MPNs).
Yuxia Pan +5 more
doaj +1 more source
, 2021 Robust calibration in CASA. The package primarily contains two CASA tasks - gaincalR and bandpassR. gaincalR solves antenna-based complex gains, but in a way that is robust to outliers. gaincalR can be used as a substitute of the standard gaincal task in CASA.
openaire +2 more sources
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Cells, 2022 Renal Ca2+ reabsorption plays a central role in the fine-tuning of whole-body Ca2+ homeostasis. Here, we identified calreticulin (Calr) as a missing link in Ca2+ handling in the kidney and showed that a shortage of Calr results in mitochondrial disease ...
Asima Tayyeb +11 more
doaj +1 more source
Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish
, 2017 CALR mutations are identified in about 30% of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs) including essential thrombocythemia (ET) and primary myelofibrosis.
Lim, K-H;Chang, Y-C;Chiang, Y-H;Lin, H-C;Chang, C-Y;Lin, C-S;Huang, L.;Wang, W-T;Chen, C. Gon-Shen;Chou, W-C;Kuo, Y-Y +1 more
core +1 more source
CALR mutation characterization in myeloproliferative neoplasms
Oncotarget, 2016 Identification of somatic frameshift mutations in exon 9 of the calreticulin gene (CALR) in myeloproliferative neoplasms (MPNs) in December of 2013 has been a remarkable finding. It has provided a new molecular diagnostic marker, particularly in essential thrombocythemia (ET) and primary myelofibrosis (PMF), where is the second most common altered gene
Bilbao-Sieyro, Cristina +2 more
openaire +3 more sources
Advanced Science, EarlyView.A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian +14 more
wiley +1 more source
Molecular Genetic Markers and Clinical Characteristics of Essential Thrombocythemia
Клиническая онкогематология, 2017 Background & Aims. The presence of different molecular genetic markers of clonality (mutations in JAK2, MPL, CALR) or their absence (triple negative status, TN) in essential thrombocythemia (ET) indicates a biological heterogeneity of the disease and can
Anastasiya Andreevna Zhernyakova +13 more
doaj +1 more source
Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics
Animal Research and One Health, EarlyView.Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley +1 more source
Pro- and Antifibrotic Factors in the Serum of Patients with Chronic Myeloproliferative Disorders
Клиническая онкогематология, 2017 Background. The study of pro- and antifibrotic factors in the serum of patients with Ph-negative chronic myeloproliferative disorders (CMPDs) will allow to understand better the mechanisms of myelofibrosis development, as well as to identify new ...
A. A. Silyutina +7 more
doaj +1 more source