Results 71 to 80 of about 12,091 (231)

Buccal epithelial cells display somatic, bone marrow–derived CALR mutation

, 2017
Key Points Buccal epithelial cells harbor an MPN-associated CALR mutation in a patient with CALR-mutant essential thrombocytosis, Ph+ CML, and no germ line CALR mutation.
Scott R. Gilles, Elizabeth L. Courville, Matthew L. Schomaker, Zohar Sachs, Linda B. Baughn, Andrew C. Nelson   +5 more
core   +1 more source

Molecular Mechanism of Mutant CALR–Mediated Transformation [PDF]

Cancer Discovery, 2016
Abstract Summary: Elf and colleagues used an elegant series of functional and biochemical assays to investigate the molecular mechanism of mutant calreticulin (CALR)–driven cellular transformation in myeloproliferative neoplasms (MPN).
Robert F, Stanley, Ulrich, Steidl
openaire   +2 more sources

Survival outcomes and treatment patterns in myelofibrosis in the JAK inhibitor era

British Journal of Haematology, EarlyView.
Summary Data on real‐world survival and treatment patterns in large, unselected myelofibrosis (MF) cohorts remain limited. We analysed 1649 patients with MF diagnosed from 2010 onwards and included in the Spanish Myelofibrosis Registry across 64 centres. Janus kinase (JAK) inhibitors were administered to approximately half of the patients.
Juan‐Carlos Hernández‐Boluda, Eduardo Arellano‐Rodrigo, Manuel Pérez‐Encinas, José‐María Raya, María‐Teresa Gómez‐Casares, Francisca Ferrer‐Marín, Alberto Hernández‐Sánchez, María‐Laura Fox, Anna Angona, Beatriz Cuevas, María‐Isabel Mata‐Vázquez, Rosa Ayala, Natalia de las Heras, Elvira Mora, Valentín García‐Gutiérrez, Alicia Senín, Jasson Villarreal, Blanca Xicoy, Raúl Pérez‐López, María García‐Fortes, Sonia González de Villambrosia, Elena Magro, María‐José Ramírez, Paula Gómez, Angel Ramírez‐Payer, Clara Martínez‐Valverde, Lucía Pérez‐Lamas, Carmen García‐Hernández, Mercedes Gasior, Luis‐Miguel Juárez‐Salcedo, Francisco Ibáñez, María‐Luisa Antelo, Lucía Guerrero, Alberto Alvarez‐Larrán, Arturo Pereira, on behalf of the Spanish MPN Group (GEMFIN)   +35 more
wiley   +1 more source

Estimated pulse wave velocity as a marker of major adverse cardiovascular events in essential thrombocythaemia and polycythaemia vera

British Journal of Haematology, EarlyView.
In patients with essential thrombocythaemia or polycythaemia vera, higher estimated pulse wave velocity (ePWV) was independently associated with major adverse cardiovascular events, while its relationship with overall survival was largely age‐driven.
Alessandro Costa, Olga Mulas, Federica Pilo, Eleonora Atzeni, Martina Pettinau, Daniela Mantovani, Giovanni Caocci   +6 more
wiley   +1 more source

The role of calreticulin (CALR) in vertebrate hematopoiesis

, 2016
Calreticulin (CALR) is a multi-functional protein mainly controlling protein folding and calcium homeostasis in endoplasmic reticulum (ER). Recently, recurrent mutations in CALR have been found in essential thrombocythemia (ET) and primary myelofibrosis (
文岐方, Man, Ki-fong
core   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Calreticulin mutations in Chinese with primary myelofibrosis

Haematologica, 2014
We tested 357 Chinese with primary myelofibrosis for mutations in CALR, JAK2 and MPL. CALR mutations were detected in 76 subjects (21%). There were 24 (32%) type-1 (L367fs*46) and 49 (64%) type-2 (K385fs*47) mutations.
Bing Li, Junqing Xu, Jingya Wang, Robert Peter Gale, Zefeng Xu, Yajuan Cui, Lin Yang, Ruixian Xing, Xiaofei Ai, Tiejun Qin, Yue Zhang, Peihong Zhang, Zhijian Xiao   +12 more
doaj   +1 more source

Expression analyses in Calr overexpressing ATDC5 cells.

, 2016
RT-qPCR expression of Calr, Dio2 and Acan in ATDC5 cells transfected with either a Calr-containing vector for overexpression (Calr+) or 3 unique 27mer siRNA duplexes, specific for Calr, for knockdown (Calr-).
Rik J. U. Lories (2741824), Frederique M. F. Cornelis (2741830), Ingrid Meulenbelt (174801), Yolande F. M. Ramos (603081), Nico Lakenberg (603084), Nils Bomer (603083), Ruud van der Breggen (188383), P. Eline Slagboom (28184), Wouter den Hollander (603082), Lies Storms (2741827)   +9 more
core   +1 more source

Venous Thromboembolism in Hematologic Malignancies: Incidence, Risk Factors, and the Role of Direct Oral Anticoagulants

European Journal of Haematology, EarlyView.
ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto, Silvia Sorella, Erminia Baldacci, Massimo Breccia, Sabina Chiaretti, Marcello Capriata, Livia Donzelli, Gianna Maria D'Elia, Salvatore Giacomo Morano, Ilaria Del Giudice, Maurizio Martelli, Cristina Santoro, Antonio Chistolini   +12 more
wiley   +1 more source

CALR online Linguistic Journal

, 2012
CALR online Linguistic Journal Sujet : The online Linguistic Journal of CALR (Centre for Applied Linguistic Research) is an open access, ISSN referenced, and internationally refereed online journal that publishes works from several fields of ...
Dominique Poggi
core   +1 more source