Results 81 to 90 of about 12,091 (231)

Allelic imbalance in CALR somatic mutagenesis

, 2015
Interestingly, after JAK2, our observation on allelic imbalance of CALR mutations describes the second such case involved in MPN pathogenesis. It remains to be seen whether other cancer-associated loci exhibit biases in the acquisition of somatic ...
Pietra, D, D Pietra, M Cazzola, Berg, T, D Chen, H Gisslinger, B Gisslinger, R Kralovics, Harutyunyan, As, RUMI, ELISA, CAZZOLA, MARIO, E Rumi, Gisslinger, H, Gisslinger, B, Chen, D, A S Harutyunyan, R Jäger, T Berg, Kralovics, R.5., Jäger, R   +19 more
core   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

Biological Biomarkers in Proliferative Verrucous Leukoplakia: A Systematic Review and Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Objective To synthesise biological biomarker evidence in proliferative verrucous leukoplakia/proliferative leukoplakia and quantify malignant transformation using eligible longitudinal evidence. Methods Primary human biomarker studies and longitudinal studies reporting extractable malignant‐transformation events and denominators were ...
Madawi Faisal Alkeheli, Hisham I. Othman
wiley   +1 more source

Calreticulin in Essential Thrombocythemia: StressINg OUT the Megakaryocyte Nucleus

Frontiers in Oncology, 2017
Calreticulin (CALR) is a multifaceted protein primarily involved in intracellular protein control processes. The identification of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis that are mutually exclusive with the JAK2 V617F ...
Francisco Jose Iborra, Petros Papadopoulos   +1 more
doaj   +1 more source

CALR Mutations in Myeloproliferative Neoplasms

International Journal of Gerontology, 2014
detected in approximately 40% of patients with essential thrombocythemia (ET) in our cohort and others’ cohorts. With the help of the next-generation sequencing technique, two study groups have recently demonstrated a high frequency of calreticulin (CALR) exon 9 mutations in patients with JAK2V617F-negative ET and primary myelofibrosis 3,4 .
Lim, Ken-Hong, Lin, Huan-Chau, Gon-Shen Chen, Caleb, Chiang, Yi-Hao, Hsiao, Chung-Der, Kuo, Yuan-Yeh   +5 more
openaire   +2 more sources

Identification of variants in EXON 09 of the calreticulin gene (CALR) in patients with essential thrombocythemia and myelofibrosis

, 2023
BCR::ABL1 negative myeloproliferative neoplasms are hematological changes with clonal proliferative characteristics that affect one or more lineages of the myeloid group, including essential thrombocythemia and myelofibrosis.
Mesquita, Éricka Alves de
core   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2 [PDF]

, 2013
Item does not contain fulltextBACKGROUND: Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is obscure, and the diagnosis of
Avezov, E, Hinton, J., Kollmann, K., Cross, N.CP., Avezov, E., Kollmann, Karoline, Mudie, Laura, Cross, N.C.P., Aziz, A., Papaemmanuil, E., Martincorena, Inigo, Goudie, Calum T., Nangalia, Jyoti, Harrison, C.N., Maddison, Mark, Jones, A.V., Teague, Jon W., Orchard, Kim, Ortmann, Christina A., Bloxham, David, Li, J., Bianchi, Michele, Huntly, B.JP., Massie, C.E., Ron, D., Cross, Nicholas C. P., Van Loo, P., McLaren, S., Tauro, S., Tarpey, Patrick, Vannucchi, A.M., Kent, DG, Tarpey, P., Baxter, E.J., Harrison, Claire N., Nangalia, J, Butler, Adam P., Guglielmelli, Paola, Loo, P. Van, Bianchi, M., Hinton, Jonathan, Loughran, Stephen J., Kent, D.G., Li, Juan, Kent, David G., Raine, K., Nice, F.L., Massie, CE, Martincorena, I., Harding, H.P., Huntly, B.J.P., Godfrey, A.L., Orchard, K., Bloxham, D., Jones, David R., Baxter, E. Joanna, Green, A. R., Van Loo, Peter, Kollmann, K, Avezov, Edward, Aziz, Athar, Ron, David, Silber, Yvonne, Greaves, M., Campbell, P.J., O'Meara, Sarah, Hill, K., Nangalia, J., Huntly, B.J., Robinson, B., Robinson, Ben, Du, M.-Q., Tauro, Sudhir, Aziz, A; et al., Maclean, Cathy, Du, M.Q., Huntly, Brian J. P., Hill, Kate, Nice, FL, Keohane, Clodagh, Mudie, L., Campbell, Peter J., Dimitropoulou, Danai, Cross, N.C., Silber, Y., Du, Ming-Qing, Godfrey, Anna L., Fitzpatrick, John D., Harding, Heather P., Green, Anthony R., Maclean, C., Gundem, Gunes, Li, J, Jones, D.R., Fitzpatrick, J.D., Teague, J.W., Wedge, D.C.; id_orcid, O'Meara, S., Baxter, EJ, Gundem, G, Keohane, C., Guglielmelli, P., Loughran, S.J., Bowen, David, McLaren, Stuart, Green, A.R., Greaves, Mel, Wedge, David C., Massie, Charles E., Gundem, G., Maddison, M., Du, M-Q., Dimitropoulou, D., Papaemmanuil, Elli, Wedge, DC, Wedge, D.C., Goudie, C.T., Raine, Keiran, Ortmann, C.A., Jones, Amy V., Nice, Francesca L., Bowen, D., Butler, A.P., Vannucchi, Alessandro M.   +123 more
core   +1 more source

Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend Four weeks of semaglutide treatment causes significant reductions in total body weight, fat mass, lean mass, and grip strength in mice with diet induced obesity. Mice treated with semaglutide lost a greater amount of total body weight and fat mass compared to mice fed fed a calorie matched diet.
S. Jeromson, B. Baranowski, M. Akcan, B. D. Waters, K. Eisner, A. Bellucci, S. Trang, A. Abolhassani, M. A. Tello‐Palencia, A. Schweitzer, B. Stefanska, C. J. Mitchell, David C. Wright   +12 more
wiley   +1 more source

Effect of miR-206 on CALR-mediated metastasis of human breast cancer stem cells.

, 2022
Cells were treated with miR-206 mimics, miR-206 mimics+Ad-CALR and Ad-CALR for 48 h, respectively. (A) invasive breast cancer stem cells were counted; (B&D), CALR protein expression was measured by Western blotting analysis; C, CALR gene was measured by ...
Fengxiang Zhang (352698), Chenguang Li (338444), Dapeng Sun (319496)   +2 more
core   +1 more source