Results 101 to 110 of about 12,091 (231)

Clinicopathologic Characteristics of Somatic TP53 Mutations in Philadelphia Chromosome–Negative Myeloproliferative Neoplasms: A Systematic Review

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Background TP53 mutations (TP53m) are uncommon in chronic‐phase Ph–negative myeloproliferative neoplasms but become enriched in myelofibrosis (MF) and accelerated/blast phase myeloproliferative (AP/BP‐MPN). Their prevalence, allelic distribution, and phase‐stratified outcomes have not been systematically synthesized.
Mahmood Aldapt, Rasha Kaddoura, Ahmed O. Saleh, Mostafa Najim, Ahmad Salem, Abdulrahman F. Al‐Mashdali, Bassam Muthanna, Ruba Adel Aweer, Marrita Rabadi, Shehab F. Mohamed   +9 more
wiley   +1 more source

Recombinant CALR polarizes and activates macrophages in tumors

Molecular Therapy: Oncology
We have created a recombinant form of calreticulin (CALR) to serve as an immune adjuvant. For many patients with immunogenically cold tumors, immunotherapies are ineffective.
Simin Manole, Neil S. Forbes
doaj   +1 more source

CalR: A Web-based Analysis Tool for Indirect Calorimetry Experiments

, 2017
We report a web-based tool for analysis of indirect calorimetry experiments which measure physiological energy balance. CalR easily imports raw data files, generates plots, and determines the most appropriate statistical tests for interpretation ...
David E. Cohen, Alexander S. Banks, Katherine B. LeClair, Raymond A. LeClair, Louise Lantier, Amir I. Mina   +5 more
core   +1 more source

Rapid, low cost and sensitive detection of Calreticulin mutations by a PCR based amplicon length differentiation assay for diagnosis of myeloproliferative neoplasms

BMC Medical Genetics, 2019
Background Calreticulin (CALR) gene mutations are currently recommended as biomarkers in diagnosis of patients with myeloproliferative neoplasms (MPN) with Jak2 V617F negative phenotype.
Ngo Tat Trung, Dao Thanh Quyen, Nghiem Xuan Hoan, Dao Phuong Giang, Tran Thi Huyen Trang, Thirumalaisamy P. Velavan, Mai Hong Bang, Le Huu Song   +7 more
doaj   +1 more source

Studying Academic Lawyers' Information Seeking to Inform the Design of Digital Law Libraries [PDF]

, 2006
We report findings from the initial phase of our study on legal information seeking, which comprised a series of semi-structured interviews and naturalistic observations of academic law students and staff looking for electronic legal information.
Makri, S, Stephann Makri, Makri, S.
core  

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson, King Long Hannah Lee, Megan Dietz, Sarah Guess, Laura White, Mara S. Varvil   +5 more
wiley   +1 more source

Proximity Proteomics Maps Candidate Cellular Uptake Pathways for Cell‐Derived Nanovesicles

Small Methods, Volume 10, Issue 19, 7 October 2026.
TurboID‐based dual‐sided proteomics compares mechanically generated cell‐derived nanovesicles with naturally secreted small extracellular vesicles. Vesicle proteomes define candidate interaction signatures, while recipient‐cell proximity labelling identifies exposure‐associated proteins.
Eisuke Kanao, Ryosuke Mizuta, Saki Tarao, Yukika Hara, Yuka Li, Kazunari Akiyoshi, Yasushi Ishihama, Koshi Imami, Yoshihiro Sasaki   +8 more
wiley   +1 more source

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice.

PLoS ONE, 2016
ObjectiveTo identify intrinsic differences in cartilage gene expression profiles between wild-type- and Dio2-/--mice, as a mechanism to investigate factors that contribute to prolonged healthy tissue homeostasis.MethodsPreviously generated microarray ...
Nils Bomer, Frederique M F Cornelis, Yolande F M Ramos, Wouter den Hollander, Nico Lakenberg, Ruud van der Breggen, Lies Storms, P Eline Slagboom, Rik J U Lories, Ingrid Meulenbelt   +9 more
doaj   +1 more source

Haematopoietic Cells Deficient for Calreticulin or Expressing Its Oncogenic Variants Maintain Functional Antigen Presentation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Intact antigen presentation in cancer cells is a key prerequisite for endogenous anticancer T cell responses and a starting point for immunotherapy. Calreticulin was postulated as a chaperone and integral part of the peptide‐loading complex of MHC‐I.
Maria Höhrhan, Laura Antonio‐Herrera, Henrique G. Colaço, Anja Wagner, Markus Unterwurzacher, Cecilia Varga, Klaus Kratochwill, Andreas Bergthaler, Robert Kralovics   +8 more
wiley   +1 more source

The role of calreticulin (CALR) in vertebrate hematopoiesis

, 2015
Introduction: Calreticulin (CALR) is a multi-functional protein mainly controlling protein folding and calcium homeostasis in endoplasmic reticulum.
Man, KF, Leung, AYH, Ma, CH
core