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Calreticulin and the Heart [PDF]

Cells, 2022
Calreticulin is an endoplasmic Ca2+ binding protein and molecular chaperone. As a cardiac embryonic gene, calreticulin is essential for heart development.
Marek Michalak, Wen-An Wang, Jody Groenendyk   +2 more
exaly   +6 more sources

Calreticulin induces dilated cardiomyopathy. [PDF]

PLoS ONE, 2013
Calreticulin, a Ca(2+)-buffering chaperone of the endoplasmic reticulum, is highly expressed in the embryonic heart and is essential for cardiac development.
Dukgyu Lee, Tatsujiro Oka, Beth Hunter, Alison Robinson, Sylvia Papp, Kimitoshi Nakamura, Wattamon Srisakuldee, Barbara E Nickel, Peter E Light, Jason R B Dyck, Gary D Lopaschuk, Elissavet Kardami, Michal Opas, Marek Michalak   +13 more
doaj   +6 more sources

Identification of a Novel Antibacterial Function of Mammalian Calreticulin [PDF]

Biomolecules
Calreticulin is a highly conserved and multifunctional molecular chaperone ubiquitously expressed in humans and animals. Beyond its well-established roles in calcium homeostasis, protein folding, and immune regulation, recent studies in aquatic species ...
Yichao Ma, Jiachen Liu, Xinming Qin, Xiaojing Cui, Qian Yang   +4 more
doaj   +4 more sources

Calreticulin: Roles in Cell-Surface Protein Expression [PDF]

Membranes, 2014
In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane ...
Hiroaki Matsunami, Yue Jiang, Matsunami Hiroaki   +2 more
exaly   +4 more sources

Brain Cells Release Calreticulin That Attracts and Activates Microglia, and Inhibits Amyloid Beta Aggregation and Neurotoxicity

Frontiers in Immunology, 2022
Calreticulin is a chaperone, normally found in the endoplasmic reticulum, but can be released by macrophages into the extracellular medium. It is also found in cerebrospinal fluid bound to amyloid beta (Aβ).
Claire Ann Butler, Guy Brown, Kyle Reid   +2 more
exaly   +3 more sources

The ever-expanding immunomodulatory role of calreticulin in cancer immunity [PDF]

Frontiers in Oncology, 2015
Calreticulin is a pleiotropic molecule that normally resides in the lumen of the endoplasmatic reticulum (ER). Here it has various functions, ranging from regulation of calcium homeostasis to ensuring proper protein folding.
Marco ede Bruyn, Valerie Rose Wiersma, Wijnand eHelfrich, Paul eEggleton, Edwin eBremer   +4 more
doaj   +2 more sources

Calreticulin Upregulation in Cervical Cancer Tissues From Patients After 10 Gy Radiation Therapy

Advances in Radiation Oncology, 2023
Purpose: Understanding the immune response during radiation therapy (RT) in a clinical setting is imperative for maximizing the efficacy of combined RT and immunotherapy.
Kohei Okada, MD, Hiro Sato, MD, PhD, Takuya Kumazawa, MD, PhD, Yasumasa Mori, MD, PhD, Tiara Bunga Mayang Permata, MD, PhD, Yuki Uchihara, PhD, Shin-ei Noda, MD, PhD, Keiji Suzuki, PhD, Hayato Ikota, MD, PhD, Hideaki Yokoo, MD, PhD, Soehartati Gondhowiardjo, MD, PhD, Takashi Nakano, MD, PhD, Tatsuya Ohno, MD, PhD, Atsushi Shibata, PhD   +13 more
doaj   +1 more source

Calreticulin: a multifunctional protein with potential therapeutic applications for chronic wounds

Frontiers in Medicine, 2023
Calreticulin is recognized as a multifunctional protein that serves an essential role in diverse biological processes that include wound healing, modification and folding of proteins, regulation of the secretory pathway, cell motility, cellular ...
Andrew P. Sawaya, Nicole M. Vecin, Jamie L. Burgess, Nkemcho Ojeh, Nkemcho Ojeh, Gabrielle DiBartolomeo, Rivka C. Stone, Irena Pastar, Marjana Tomic-Canic   +8 more
doaj   +1 more source

Prevalence of Calreticulin exon 9 Mutation in Iranian Cardiovascular Patients [PDF]

Journal of Research in Clinical Medicine, 2021
Background: Calreticulin (CALR) is a 46 kDa protein in the endoplasmic reticulum and is one of the major proteins in ca2+ binding; it has a key role in oxidative stress, transcription factor activation, and as a chaperone in newly synthesized protein and
Mohammad Javad Mohammad Taghi Zade, Najmaldin Saki, Habib Heybar   +2 more
doaj   +1 more source

Calreticulin regulates Src kinase in osteogenic differentiation from embryonic stem cells

Stem Cell Research, 2020
Calreticulin, the major Ca2+ buffer of the endoplasmic reticulum plays an important role in the choice of fate by embryonic stem cells. Using the embryoid body method of organogenesis, we showed impaired osteogenesis in crt−/− cells vis-à-vis ...
Zahra Alvandi, Layla J.R Al-Mansoori, Michal Opas   +2 more
doaj   +1 more source