Results 21 to 30 of about 30,178 (280)

Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation

Nature Communications, 2023
In myeloproliferative neoplasms, frameshift mutants of calreticulin turn into rogue cytokines by inducing constitutive activation of the Thrombopoietin Receptor (TpoR).
Nicolas Papadopoulos, Audrey Nédélec, Allison Derenne, Teodor Asvadur Şulea, Christian Pecquet, Ilyas Chachoua, Gaëlle Vertenoeil, Thomas Tilmant, Andrei-Jose Petrescu, Gabriel Mazzucchelli, Bogdan I. Iorga, Didier Vertommen, Stefan N. Constantinescu   +12 more
doaj   +1 more source

Assessments of Roles for Calreticulin in Antigen Presentation. [PDF]

, 2012
MHC class I molecules are important glycoproteins of the adaptive immune response. Assembly of MHC class I molecules occurs in the endoplasmic reticulum (ER) of cells.
Del Cid, Natasha
core   +7 more sources

Calreticulin Is Required for TGF-β-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells

Stem Cell Reports, 2017
Calreticulin, a multifunctional endoplasmic reticulum resident protein, is required for TGF-β-induced epithelial-to-mesenchymal transition (EMT) and subsequent cardiomyogenesis. Using embryoid bodies (EBs) derived from calreticulin-null and wild-type (WT)
Fereshteh Karimzadeh, Michal Opas
doaj   +1 more source

Thrombospondin-1 Signaling Through the Calreticulin/LDL Receptor Related Protein 1 Axis: Functions and Possible Roles in Glaucoma

Frontiers in Cell and Developmental Biology, 2022
Thrombospondin-1 (TSP-1) is a matricellular extracellular matrix protein. Matricellular proteins are components of the extracellular matrix (ECM) that regulate key cellular functions and impact ECM organization, but which lack direct primary structural ...
Joanne E. Murphy-Ullrich, Joanne E. Murphy-Ullrich, Joanne E. Murphy-Ullrich   +2 more
doaj   +1 more source

Essential thrombocythemia with (type2) calreticulin presented as stuttering priapism case report and review of literature

Clinical Case Reports, 2021
Priapism is a rare presentation and complication of ET that might be underreported. In ET, priapism can present as an ischemic or stuttering type. These patients are more likely to be anemic and have a high platelet count.
Elrazi Awadelkarim Ali, Abdulqadir Jeprel Nashwan, Mohamed A Yassin   +2 more
doaj   +1 more source

Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow

Frontiers in Immunology, 2023
BackgroundTherapeutic cancer vaccination against mutant calreticulin (CALR) in patients with CALR-mutant (CALRmut) myeloproliferative neoplasms (MPN) induces strong T-cell responses against mutant CALR yet fails to demonstrate clinical activity ...
Morten Orebo Holmström, Morten Orebo Holmström, Morten Andersen, Sofie Traynor, Shamaila Munir Ahmad, Thomas Landkildehus Lisle, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Johnny T. Ottesen, Morten Frier Gjerstorff, Morten Frier Gjerstorff, Hans Carl Hasselbalch, Mads Hald Andersen, Mads Hald Andersen   +14 more
doaj   +1 more source

Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia

Frontiers in Immunology, 2019
Opsonins are soluble, extracellular proteins, released by activated immune cells, and when bound to a target cell, can induce phagocytes to phagocytose the target cell. There are three known classes of opsonin: antibodies, complement factors and secreted
Tom O. J. Cockram, Mar Puigdellívol, Guy C. Brown   +2 more
doaj   +1 more source

Calreticulin and Arginylated Calreticulin Have Different Susceptibilities to Proteasomal Degradation [PDF]

Journal of Biological Chemistry, 2015
Post-translational arginylation has been suggested to target proteins for proteasomal degradation. The degradation mechanism for arginylated calreticulin (R-CRT) localized in the cytoplasm is unknown. To evaluate the effect of arginylation on CRT stability, we examined the metabolic fates and degradation mechanisms of cytoplasmic CRT and R-CRT in NIH ...
Victor Goitea, Marta E. Hallak
openaire   +3 more sources

Functional specialization of calreticulin domains [PDF]

, 2001
Calreticulin is a Ca2+-binding chaperone in the endoplasmic reticulum (ER), and calreticulin gene knockout is embryonic lethal. Here, we used calreticulin-deficient mouse embryonic fibroblasts to examine the function of calreticulin as a regulator of Ca2+
Zuppini, A., Nakamura, K., Marek Michalak, Jan B. Parys, Irfan Ahsan, Michal Opas, Parys, J. B., Opas, M., De Smedt, H., Lew, Daniel Pablo, Nicolas Demaurex, Ahsan, I., Daniel P. Lew, Werner Müller-Esterl, Karl-Heinz Krause, Jeffery Lynch, Muller-Esterl, W., Ryoko Krause, Sylvia Papp, Michalak, Marek, Kimitoshi Nakamura, Anna Zuppini, Arnaudeau, Serge, Lynch, J., Krause, R., Krause, Karl-Heinz, Demaurex, Nicolas, Papp, S., Humbert De Smedt, Serge Arnaudeau   +29 more
core   +1 more source

Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.

PLoS ONE, 2013
Dysregulation of the proteolytic processing of amyloid precursor protein by γ-secretase and the ensuing generation of amyloid-β is associated with the pathogenesis of Alzheimer's disease.
Nina Stemmer, Elena Strekalova, Nevena Djogo, Frank Plöger, Gabriele Loers, David Lutz, Friedrich Buck, Marek Michalak, Melitta Schachner, Ralf Kleene   +9 more
doaj   +1 more source