Results 31 to 40 of about 28,252 (277)
Frontiers in Cell and Developmental Biology, 2022 Thrombospondin-1 (TSP-1) is a matricellular extracellular matrix protein. Matricellular proteins are components of the extracellular matrix (ECM) that regulate key cellular functions and impact ECM organization, but which lack direct primary structural ...
Joanne E. Murphy-Ullrich +2 more
doaj +1 more source
Functional specialization of calreticulin domains [PDF]
, 2001 Calreticulin is a Ca2+-binding chaperone in the endoplasmic reticulum (ER), and calreticulin gene knockout is embryonic lethal. Here, we used calreticulin-deficient mouse embryonic fibroblasts to examine the function of calreticulin as a regulator of Ca2+
Zuppini, A. +29 more
core +1 more source
Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia [PDF]
, 2010 The unfolded protein response (UPR) is triggered by the accumulation of misfolded proteins within the endoplasmic reticulum (ER). The role of the UPR during leukemogenesis is unknown so far.
Timchenko, Nikolai A +4 more
core +1 more source
Clinical Case Reports, 2021 Priapism is a rare presentation and complication of ET that might be underreported. In ET, priapism can present as an ischemic or stuttering type. These patients are more likely to be anemic and have a high platelet count.
Elrazi Awadelkarim Ali +2 more
doaj +1 more source
European Journal of Biochemistry, 2003 Increasing evidence suggests that melatonin can exert some effect at nuclear level. Previous experiments using binding techniques clearly showed the existence of specific melatonin binding sites in cell nucleus of rat liver. To further identify these sites, nuclear extracts from rat hepatocytes were treated with different percentages of ammonium ...
Manuel, Macías +6 more
openaire +2 more sources
Frontiers in Immunology, 2023 BackgroundTherapeutic cancer vaccination against mutant calreticulin (CALR) in patients with CALR-mutant (CALRmut) myeloproliferative neoplasms (MPN) induces strong T-cell responses against mutant CALR yet fails to demonstrate clinical activity ...
Morten Orebo Holmström +14 more
doaj +1 more source
Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia
Frontiers in Immunology, 2019 Opsonins are soluble, extracellular proteins, released by activated immune cells, and when bound to a target cell, can induce phagocytes to phagocytose the target cell. There are three known classes of opsonin: antibodies, complement factors and secreted
Tom O. J. Cockram +2 more
doaj +1 more source
Calreticulin and Arginylated Calreticulin Have Different Susceptibilities to Proteasomal Degradation [PDF]
Journal of Biological Chemistry, 2015 Post-translational arginylation has been suggested to target proteins for proteasomal degradation. The degradation mechanism for arginylated calreticulin (R-CRT) localized in the cytoplasm is unknown. To evaluate the effect of arginylation on CRT stability, we examined the metabolic fates and degradation mechanisms of cytoplasmic CRT and R-CRT in NIH ...
Victor Goitea, Marta E. Hallak
openaire +3 more sources
PLoS ONE, 2013 Dysregulation of the proteolytic processing of amyloid precursor protein by γ-secretase and the ensuing generation of amyloid-β is associated with the pathogenesis of Alzheimer's disease.
Nina Stemmer +9 more
doaj +1 more source
Calreticulin couples with immune checkpoints in pancreatic cancer
Clinical and Translational Medicine, 2020 Although immune checkpoint blockade is considered to be the dominant approach in future cancer immunotherapy, whether it will apply to pancreatic cancer remains largely unknown.
Xing Huang +4 more
doaj +1 more source