Results 51 to 60 of about 30,178 (280)
Calreticulin Mutations Activate MPL Signaling and Calreticulin Expression Can Modulate MPL Signaling [PDF]
, 2020 Myeloproliferative Neoplasms are a collection of blood cancers in which there is a dysregulation of hematopoiesis leading to an over proliferation of myeloid cells. These are often caused by activating mutations in non-receptor tyrosine kinases. Recently,
Brooks, Stefan
core +1 more source
Bioengineering & Translational Medicine, 2023 The development of an optimal treatment modality to improve the therapeutic outcome of breast cancer patients is still difficult. Poor antigen presentation to T cells is a major challenge in cancer immunotherapy.
Asmita Banstola +5 more
doaj +1 more source
Advanced Science, EarlyView.A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee +6 more
wiley +1 more source
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source
Down-regulation of calreticulin promotes apoptosis in hepatic stellate cells
Di-san junyi daxue xuebao, 2021 Objective To investigate the effect of calreticulin (CALR) down-regulation on apoptosis and endoplasmic reticulum stress (ERS) pathway in hepatic stellate cells (HSCs).
DAI Linyu +3 more
doaj +1 more source
Calreticulins are not all the same [PDF]
Proceedings of the National Academy of Sciences, 2009 no ...
openaire +4 more sources
Advanced Science, EarlyView.We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai +9 more
wiley +1 more source
Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy
Advanced Science, EarlyView.Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan +14 more
wiley +1 more source
Modulation of integrin function by calreticulin [PDF]
, 1998 grantor: University of TorontoIntegrins are commonly referred to as mediators of both "outside-in" and "inside-out" transmembrane signal transduction.
Coppolino, Marc Gabriel
core +2 more sources
eLife, 2019 Adiponectin is an adipocyte-derived atypically abundant circulating factor that protects various organs and tissues through its receptors, AdipoRs, calreticulin, and T-cadherin.
Shunbun Kita +3 more
doaj +1 more source