Results 71 to 80 of about 30,178 (280)
Frontiers in Immunology, 2017 Calreticulin (CRT) is a well-known “eat-me” signal harbored by dying cells participating in their recognition by phagocytes. CRT is also recognized to deeply impact the immune response to altered self-cells.
Rim Osman +4 more
doaj +1 more source
Advanced Science, EarlyView.A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou +9 more
wiley +1 more source
Unfolded protein response suppresses CEBPA by induction of calreticulin in acute myeloid leukaemia
, 2010 The unfolded protein response (UPR) is triggered by the accumulation of misfolded proteins within the endoplasmic reticulum (ER). The role of the UPR during leukemogenesis is unknown so far.
Timchenko, Nikolai A +4 more
core +1 more source
Advanced Science, EarlyView.DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu +6 more
wiley +1 more source
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
Dimerization and oligomerization of the chaperone calreticulin [PDF]
European Journal of Biochemistry, 2003 The chaperone calreticulin is a highly conserved eukaryotic protein mainly located in the endoplasmic reticulum. It contains a free cysteine SH group but does not form disulfide‐bridged dimers under physiological conditions, indicating that the SH group may not be fully accessible in the native protein.
Jørgensen, Charlotte S +7 more
openaire +2 more sources
Calreticulin and cell adhesion
, 2002 An understanding of cell-cell and cell-matrix adhesions and how they are influenced is central to cell biology. Calreticulin is a multifunctional calcium binding protein of the endoplasmic reticulum of all eukaryotic cells that influences a wide variety ...
Fadel, Marc Pierre
core +1 more source
Suppression of Cx43 promoter by calreticulin.
, 2013 (A) A schematic representation of calreticulin and calreticulin domains. CRT, calreticulin full length tagged with HA epitope; CRT-PC, P+C domain of calreticulin tagged with HA epitope. HA, hemagglutinin; KDEL, ER retrieval amino acid sequence.
Wattamon Srisakuldee (380080) +13 more
core +1 more source
Advanced Science, EarlyView.An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu +10 more
wiley +1 more source
Advanced Science, EarlyView.Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu +11 more
wiley +1 more source