Results 71 to 80 of about 28,252 (277)
Advanced Science, EarlyView.RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu +13 more
wiley +1 more source
Calreticulin and cell adhesion [PDF]
, 2002 An understanding of cell-cell and cell-matrix adhesions and how they are influenced is central to cell biology. Calreticulin is a multifunctional calcium binding protein of the endoplasmic reticulum of all eukaryotic cells that influences a wide variety ...
Fadel, Marc Pierre
core
Calreticulin Mutations Activate MPL Signaling and Calreticulin Expression Can Modulate MPL Signaling [PDF]
, 2020 Myeloproliferative Neoplasms are a collection of blood cancers in which there is a dysregulation of hematopoiesis leading to an over proliferation of myeloid cells. These are often caused by activating mutations in non-receptor tyrosine kinases. Recently,
Brooks, Stefan
core
A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
OncoImmunology, 2018 Immune evasion is an important driver of disease progression in the plasma cell malignancy multiple myeloma. Recent work highlights the potential of epigenetic modulating agents as tool to enhance anti-tumor immunity. The immune modulating effects of the
Lien De Beck +7 more
doaj +1 more source
Mutant calreticulin in myeloproliferative neoplasms [PDF]
Blood, 2019 In a Blood Spotlight that is also this month’s CME article, the authors review the current understanding of the biology underpinning mutant CALR-driven myeloproliferative neoplasms, discuss its clinical implications, and highlight future therapeutic approaches.
Joan How +2 more
openaire +2 more sources
Peptide binding specificity of the chaperone calreticulin [PDF]
, 2007 Calreticulin is a molecular chaperone with specificity for polypeptides and N-linked monoglucosylated glycans. In order to determine the specificity of polypeptide binding, the interaction of calreticulin with polypeptides was investigated using ...
Hojrup, P. +20 more
core +1 more source
Advanced Science, EarlyView.An endoplasmic reticulum (ER)‐targeted chemodynamic nanoagent (TCBQ/iLD‐ER NPs) comprising •OH‐generating tetrachloro‐1,4‐benzoquinone (TCBQ) and lipid droplets (LDs) formation inhibitor (iLD) is developed for chemodynamic immunotherapy of tumors. After ingestion by cancer cells, TCBQ/iLD‐ER NPs preferentially accumulate in the ER and react with ER ...
Huilan Cai +12 more
wiley +1 more source
Protein changes during programmed cell death in tobacco
Biologia Plantarum, 2011 Programmed cell death (PCD) was induced by the Yariv reagent in Nicotiana tabacum cv. Bright Yellow-2 cell suspension. The analyses of proteins extracts by 2-D electrophoresis clearly show massive protein degradation which was mainly due to cysteine ...
I. Chaves +5 more
doaj +1 more source
The interaction between calreticulin and immunoglobulin G and immunoglobulin Y [PDF]
, 2011 Calreticulin is a chaperone of the endoplasmic reticulum (ER) assisting proteins in achieving the correctly folded structure. Details of the binding specificity of calreticulin are still a matter of debate.
Feizi, Ten +22 more
core +1 more source