Results 91 to 100 of about 28,252 (277)
Advanced Science, EarlyView.Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan +11 more
wiley +1 more source
The calreticulin saga: Focal adhesion to adipogenesis [PDF]
, 2007 Calreticulin is a multifunctional ER resident protein that participates in calcium homeostasis and modulation of gene expression, most notably those of genes involved in cell adhesion. Calreticulin has three domains: the N, P and the C domain.
Szabo, Eva
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Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy
Advanced Science, EarlyView.A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao +11 more
wiley +1 more source
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source
Calreticulin、VRK1、Fbxw7在弥漫大B细胞淋巴瘤中的表达及诊断价值研究
Zhongguo shiyan zhenduanxue, 2022 目的 探究弥漫大B细胞淋巴瘤（DLBCL）中钙网蛋白（Calreticulin）、牛痘相关激酶1(VRK1)、F框/WD40域蛋白7(Fbxw7)的表达及诊断价值。方法 选取2019年3月到2021年3月在秦皇岛第一医院病理科保存60例DLBCL组织以及瘤旁组织标本为DLBCL组，选取同期保存的正常的淋巴组织为正常组。采用荧光定量RT-PCR检测Calreticulin、Fbxw7，免疫组织化学法检测组织中VRK1表达。结果弥漫大B细胞淋巴瘤组织Calreticulin ...
张琳 +5 more
doaj +2 more sources
Frontiers in Immunology, 2020 Because of its capacity to increase a physiologic inflammatory response, to stimulate phagocytosis, to promote cell lysis and to enhance pathogen immunogenicity, the complement system is a crucial component of both the innate and adaptive immune ...
Galia Ramírez-Toloza +4 more
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Calreticulin—Enigmatic Discovery
BiomoleculesCalreticulin (CRT) is an intrinsically disordered multifunctional protein that plays essential roles intra-and extra-cellularly. The Michalak laboratory has proposed that CRT was initially identified in 1974 by the MacLennan laboratory as the high-affinity Ca2+-binding protein (HACBP) of the sarcoplasmic reticulin (SR).
Gillian C. Okura +2 more
openaire +3 more sources
Advanced Science, EarlyView.ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen +22 more
wiley +1 more source
Dimerization and oligomerization of the chaperone calreticulin. [PDF]
, 2003 Udgivelsesdato: 2003-OctThe chaperone calreticulin is a highly conserved eukaryotic protein mainly located in the endoplasmic reticulum. It contains a free cysteine SH group but does not form disulfide-bridged dimers under physiological conditions ...
Steinø, Anne +7 more
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