Results 111 to 120 of about 28,252 (277)
Calreticulin in Essential Thrombocythemia: StressINg OUT the Megakaryocyte Nucleus
Frontiers in Oncology, 2017 Calreticulin (CALR) is a multifaceted protein primarily involved in intracellular protein control processes. The identification of CALR mutations in essential thrombocythemia (ET) and primary myelofibrosis that are mutually exclusive with the JAK2 V617F ...
Francisco Jose Iborra +1 more
doaj +1 more source
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source
A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin
Journal of Investigative Medicine High Impact Case Reports, 2013 Background . High prevalence of autoantibodies to the calcium-binding, endoplasmic reticulum chaperone protein calreticulin has been reported in various autoimmune and parasitic diseases.
Neil M. Gude BSc, MSc, PhD +3 more
doaj +1 more source
Expression of CRT and CD47 in Gastric Carcinoma and Their Significance
Zhongliu Fangzhi Yanjiu, 2019 Objective To investigate the expression levels of calcium net protein (CRT) and CD47 in gastric cancer tissues and its relationship with clinical parameters, to explore the significance of CRT and CD47 in gastric cancer tissues.
SUN Ke +5 more
doaj +1 more source
Calreticulin Mutations in Myeloproliferative Neoplasms [PDF]
Rambam Maimonides Medical Journal, 2014 With the discovery of the JAK2V617F mutation in patients with Philadelphia chromosome-negative (Ph(-)) myeloproliferative neoplasms (MPNs) in 2005, major advances have been made in the diagnosis of MPNs, in understanding of their pathogenesis involving the JAK/STAT pathway, and finally in the development of novel therapies targeting this pathway ...
openaire +3 more sources
Advanced Science, EarlyView.We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai +9 more
wiley +1 more source
Assessments of Roles for Calreticulin in Antigen Presentation. [PDF]
, 2012 MHC class I molecules are important glycoproteins of the adaptive immune response. Assembly of MHC class I molecules occurs in the endoplasmic reticulum (ER) of cells.
Del Cid, Natasha
core
Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy
Advanced Science, EarlyView.Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan +14 more
wiley +1 more source
A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
eLifeActivating transcription factor 6 (ATF6) is one of three endoplasmic reticulum (ER) transmembrane stress sensors that mediate the unfolded protein response (UPR).
Joanne Tung +5 more
doaj +1 more source
Advanced Science, EarlyView.A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang +12 more
wiley +1 more source