Results 81 to 90 of about 30,178 (280)
Molecules, 2020 Fasciola hepatica, the causative agent of fasciolosis, is a global threat to public health, animal welfare, agricultural productivity, and food security.
Clare F. Collett +4 more
doaj +1 more source
An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer
Advanced Science, EarlyView.Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li +11 more
wiley +1 more source
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death
Cells, 2020 Doxorubicin is a strong inducer of immunogenic cell death (ICD), but it is ineffective in P-glycoprotein (Pgp)-expressing cells. Indeed, Pgp effluxes doxorubicin and impairs the immunesensitizing functions of calreticulin (CRT), an “eat-me” signal ...
Joanna Kopecka +8 more
doaj +1 more source
Advanced Science, EarlyView.A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang +10 more
wiley +1 more source
Polypeptide binding properties of the chaperone calreticulin.
, 2000 Udgivelsesdato: 2000-MayCalreticulin is a highly conserved eukaryotic ubiquitious protein located mainly in the endoplasmic reticulum. Two major characteristics of calreticulin are its chaperone activity and its lectin properties, but its precise ...
Jørgensen, C S +4 more
core +1 more source
Advanced Science, EarlyView.Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian +10 more
wiley +1 more source
Calreticulin—Enigmatic Discovery
BiomoleculesCalreticulin (CRT) is an intrinsically disordered multifunctional protein that plays essential roles intra-and extra-cellularly. The Michalak laboratory has proposed that CRT was initially identified in 1974 by the MacLennan laboratory as the high-affinity Ca2+-binding protein (HACBP) of the sarcoplasmic reticulin (SR).
Gillian C. Okura +2 more
openaire +3 more sources
Calreticulins- Calcium-binding proteins with functional diversity and evolutionary duality
, 2003 Calreticulin is a multifunctional protein mainly localized in the endoplasmic reticulum in eukaryotic organisms. The protein comprises three distinct regions: the N-terminal N domain, the C-terminal C domain, and the central P domain, reflecting the ...
Persson, Staffan Hans
core
Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Calreticulin、VRK1、Fbxw7在弥漫大B细胞淋巴瘤中的表达及诊断价值研究
Zhongguo shiyan zhenduanxue, 2022 目的 探究弥漫大B细胞淋巴瘤（DLBCL）中钙网蛋白（Calreticulin）、牛痘相关激酶1(VRK1)、F框/WD40域蛋白7(Fbxw7)的表达及诊断价值。方法 选取2019年3月到2021年3月在秦皇岛第一医院病理科保存60例DLBCL组织以及瘤旁组织标本为DLBCL组，选取同期保存的正常的淋巴组织为正常组。采用荧光定量RT-PCR检测Calreticulin、Fbxw7，免疫组织化学法检测组织中VRK1表达。结果弥漫大B细胞淋巴瘤组织Calreticulin ...
张琳 +5 more
doaj +2 more sources