Results 61 to 70 of about 30,178 (280)
Insects, 2020 A long-range migrant species of moth (Agrotis ipsilon) has served as a model to compare the expression profiles of antennal proteins between different continental populations.
Jean-François Picimbon
doaj +1 more source
The calreticulin saga: Focal adhesion to adipogenesis [PDF]
, 2007 Calreticulin is a multifunctional ER resident protein that participates in calcium homeostasis and modulation of gene expression, most notably those of genes involved in cell adhesion. Calreticulin has three domains: the N, P and the C domain.
Szabo, Eva
core +1 more source
Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy
Advanced Science, EarlyView.This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang +5 more
wiley +1 more source
Mutant calreticulin in myeloproliferative neoplasms [PDF]
Blood, 2019 In a Blood Spotlight that is also this month’s CME article, the authors review the current understanding of the biology underpinning mutant CALR-driven myeloproliferative neoplasms, discuss its clinical implications, and highlight future therapeutic approaches.
Joan How +2 more
openaire +2 more sources
Advanced Science, EarlyView.A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang +12 more
wiley +1 more source
OncoImmunology, 2018 Immune evasion is an important driver of disease progression in the plasma cell malignancy multiple myeloma. Recent work highlights the potential of epigenetic modulating agents as tool to enhance anti-tumor immunity. The immune modulating effects of the
Lien De Beck +7 more
doaj +1 more source
In the beginning and at the end: calreticulin [PDF]
Blood, 2016 In this issue of Blood, Theocharides et al report one of likely many functionally important untoward consequences of mutant calreticulin that may arise in the clinical context of myelofibrosis. Even when viewed through the narrow prism of neutrophil biology, mutant calreticulin will adversely affect myeloid cells throughout their lifespan, from the ...
openaire +2 more sources
Advanced Science, EarlyView.Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin +10 more
wiley +1 more source
Protein changes during programmed cell death in tobacco
Biologia Plantarum, 2011 Programmed cell death (PCD) was induced by the Yariv reagent in Nicotiana tabacum cv. Bright Yellow-2 cell suspension. The analyses of proteins extracts by 2-D electrophoresis clearly show massive protein degradation which was mainly due to cysteine ...
I. Chaves +5 more
doaj +1 more source
Advanced Science, EarlyView.Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley +1 more source