Results 121 to 130 of about 12,091 (231)

CALR type 1 and CALR type 2 gene mutations determination and clinical relationship with chronic myeloproliferative disorders

open access: yes, 2016
Amaç: Kronik miyeloproliferatif hastalıklar, kemik iliğinde bir ya da daha fazla miyeloeritroid hücre serisinde kontrolsüz proliferasyon ve periferik kanda artmış olgun hücre sayısı ile karakterize edilen hastalıklar grubudur.
Yaman, Miray
core  

CALR MUTATIONS IN SICILIAN ESSENTIAL THROMBOCYTHEMIA AND MYELOFIBROSIS PATIENTS. [PDF]

open access: yes
Background. Essential thrombocythemia (ET) and primary myelofibrosis (MF) are myeloproliferative neoplasms characterized by the overproduction of mature cells such as platelets (ET) or early bone marrow fibrosis due to scarring induced by highly ...
Siracusa S   +16 more
core  

P216 | COEXISTENCE OF LOW BURDEN ALLELE JAK2V617F MUTATION AND CALR OR /MPL MUTATIONS IN A LARGE COHORT OF PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS

open access: yesHaematologica
Chronic myeloproliferative neoplasms (MPNs) are clonal hematological disorders originating from altered myeloid cell proliferation in the bone marrow (BM) and peripheral blood (PB).
C. Barbato   +18 more
doaj  

Clinical characteristics and whole exome sequencing in JAK2V617F- and CALR-unmutated essential thrombocythemia

open access: yesHematology
Objectives The aim of this study was to characterize the clinical features and outcomes of patients with JAK2 V617F- and CALR-unmutated essential thrombocythemia (ET) and to identify potential driver mutations through whole-exome sequencing (WES).Methods
Siraphop Thammayot   +13 more
doaj   +1 more source

Non–Endoplasmic Reticulum–Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function

open access: yes, 2018
Objective— In resistance arteries, endothelial cell (EC) extensions can make contact with smooth muscle cells, forming myoendothelial junction at holes in the internal elastic lamina (HIEL).
Swapnil K. Sonkusare   +7 more
core   +1 more source

Reduction of calreticulin and ERp57 with age reveals the ER stress-related roles in cell viability and organismal lifespan regulation

open access: yesFrontiers in Aging
IntroductionDefects in Calreticulin (Calr) and ER protein 57 (ERp57), two tandem endoplasmic reticulum (ER) resident proteins, are associated with pathologies ranging from protein conformational disorders to impaired immune responses but are not directly
Gracie Burdeos   +2 more
doaj   +1 more source

Ca+2 and Nε-lysine acetylation regulate the CALR-ATG9A interaction in the lumen of the endoplasmic reticulum

open access: yesScientific Reports
The acetylation of autophagy protein 9 A (ATG9A) in the lumen of the endoplasmic reticulum (ER) by ATase1 and ATase2 regulates the induction of reticulophagy.
Megan M. Braun   +6 more
doaj   +1 more source

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