Results 1 to 10 of about 20,756 (163)

Imbalance of c-MPL Isoform Promotes Tumorigenesis by Activating STAT-5 in Leukemic Cell Lines. [PDF]

Curr Issues Mol Biol
Leukemia is a hematopoietic defect, involving complex molecular and cellular alterations, in which dysregulated signaling through hematopoietic receptors, including c-MPL (c-Myeloproliferative Leukemia), has been implicated.
Hussain MA, Kulkarni M, Valder RS, Laha S.   +3 more
europepmc   +2 more sources

Coexistence of atopic dermatitis and thrombocytosis: diagnostic odyssey: a case report

Journal of Biochemical and Clinical Genetics, 2023
Background: Atopic dermatitis (AD) is one of the most common diseases encountered in pediatric practice. Genetic factors play a role in the development of this condition.
Fuad Al Mutairi, Meshal Alberreet, Lara Alkuhaimi, Khalid Aleisa, Rana Almana, Asma Awadalla   +5 more
doaj   +1 more source

Storage of packed red blood cells impairs an inherent coagulation property of erythrocytes

Frontiers in Physiology, 2022
Storage of packed red blood cells is associated with changes in erythrocytes that over time increasingly impair cellular function and potentially contribute to adverse effects associated with blood transfusion. Exposure of phosphatidylserine at the outer
Thomas Öhlinger, Thomas Öhlinger, Ernst W. Müllner, Magdalena Fritz, Maike Werning, Joanna Baron-Stefaniak, Christof Jungbauer, David M. Baron, Ulrich Salzer   +8 more
doaj   +1 more source

Endocytosis of the thrombopoietin receptor Mpl regulates megakaryocyte and erythroid maturation in mice

Frontiers in Oncology, 2022
Dnm2fl/fl Pf4-Cre (Dnm2Plt–/–) mice lacking the endocytic GTPase dynamin 2 (DNM2) in platelets and megakaryocytes (MKs) develop hallmarks of myelofibrosis.
Nathan Eaton, Nathan Eaton, Emily K. Boyd, Emily K. Boyd, Ratnashree Biswas, Melissa M. Lee-Sundlov, Theresa A. Dlugi, Haley E. Ramsey, Haley E. Ramsey, Shikan Zheng, Robert T. Burns, Martha C. Sola-Visner, Martha C. Sola-Visner, Karin M. Hoffmeister, Karin M. Hoffmeister, Hervé Falet, Hervé Falet   +16 more
doaj   +1 more source

Mutation Profile in BCR-ABL1-Negative Myeloproliferative Neoplasms: A Single-Center Experience From India

Hematology/Oncology and Stem Cell Therapy, 2022
Objective/Background: Recurrent somatic mutations in the JAK2, calreticulin (CALR), and the MPL genes are described as drivers of BCR-ABL1-negative myeloproliferative neoplasms (MPN) that includes polycythemia vera (PV), essential thrombocytosis (ET ...
Madhavi Maddali, Uday Prakash Kulkarni, Niveditha Ravindra, Arun Kumar Arunachalam, Arvind Venkatraman, Sharon Lionel, Marie Therese Manipadam, Anup J. Devasia, Anu Korula, N.A. Fouzia, Aby Abraham, Alok Srivastava, Biju George, Poonkuzhali Balasubramanian, Vikram Mathews   +14 more
doaj   +1 more source

LEARNING OBSTACLE MAHASISWA PADA FUNGSI PEMBANGKIT DITINJAU DARI KEMAMPUAN AWAL

Jurnal E-DuMath, 2020
Tujuan dari penelitian ini adalah untuk mengetahui learning obstacles mahasiswa yang akan dideskripsikan berdasarkan berbagai jenis kesalahan dalam menyelesaikan soal fungsi pembangkit ditinjau dari kemampuan awal.
Nurmitasari Nurmitasari, Robia Astuti
doaj   +1 more source

JAK2/STAT5 Pathway Mutation Frequencies in South African BCR/ABL Negative MPN Patients

Hematology/Oncology and Stem Cell Therapy, 2023
Background: Mutations in JAK2/STAT5 proliferation pathway genes are key in the diagnosis of myeloproliferative neoplasms (MPNBCR/ABLneg), with JAK2V617F being found in 50-97% of MPNBCR/ABLneg subtypes.
Karen L. Shires, Adriana J. Rust, Rushil Harryparsad, Justin A. Coburn, Ruth E. Gopie   +4 more
doaj   +1 more source

MPLS-TE and MPLS VPNS with openflow [PDF]

ACM SIGCOMM Computer Communication Review, 2011
We demonstrate MPLS Traffic Engineering (MPLS-TE) and MPLS-based Virtual Private Networks (MPLS VPNs) using OpenFlow [1] and NOX [6]. The demonstration is the outcome of an engineering experiment to answer the following questions: How hard is it to implement a complex control plane on top of a network controller such as NOX?
Ali Reza Sharafat, Saurav Das, Guru Parulkar, Nick McKeown   +3 more
openaire   +1 more source

Two Distinct Superoxidase Dismutases (SOD) Secreted by the Helminth Parasite Fasciola hepatica Play Roles in Defence against Metabolic and Host Immune Cell-Derived Reactive Oxygen Species (ROS) during Growth and Development

Antioxidants, 2022
The antioxidant superoxide dismutase (SOD) catalyses the dismutation of superoxide, a dangerous oxygen free radical, into hydrogen peroxide and molecular oxygen. Superoxide generation during the oxidative burst of the innate immune system is considered a
Nichola Eliza Davies Calvani, Carolina De Marco Verissimo, Heather Louise Jewhurst, Krystyna Cwiklinski, Andrew Flaus, John Pius Dalton   +5 more
doaj   +1 more source

MENINGKATKAN HASIL BELAJAR SISWA MELALUI AKTIVITAS BELAJAR KELOMPOK

Jurnal E-DuMath, 2018
The purpose of this study is to reveal the differences in student learning outcomes before and after applied in the learning group learning activities through pretest and posttest.
Binti Anisaul Khasanah, Nurmitasari Nurmitasari   +1 more
doaj   +1 more source