Results 11 to 20 of about 29,777 (280)

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis [PDF]

Frontiers in Endocrinology, 2017
Megakaryopoiesis is an original and complex cell process which leads to the formation of platelets. The homeostatic production of platelets is mainly regulated and controlled by thrombopoietin (TPO) and the TPO receptor (MPL)/JAK2 axis.
Isabelle Plo, Isabelle Plo, Isabelle Plo, Christine Bellanné-Chantelot, Christine Bellanné-Chantelot, Matthieu Mosca, Matthieu Mosca, Matthieu Mosca, Stefania Mazzi, Stefania Mazzi, Stefania Mazzi, Caroline Marty, Caroline Marty, Caroline Marty, William Vainchenker, William Vainchenker, William Vainchenker   +16 more
doaj   +2 more sources

MPL W515L/K Mutations in Chronic Myeloproliferative Neoplasms

Turkish Journal of Hematology, 2013
OBJECTIVE: The MPL gene encodes the thrombopoietin receptor. Recently MPL mutations (MPL W515L or MPL W515K) were described in patients with essential thrombocythemia (ET) and primary (idiopathic) myelofibrosis (PMF).
Timur Selçuk Akpınar, Veysel Sabri Hançer, Meliha Nalçacı, Reyhan Diz- Küçükkaya   +3 more
doaj   +2 more sources

Identification of MPL R102P Mutation in Hereditary Thrombocytosis [PDF]

Frontiers in Endocrinology, 2017
The molecular basis of hereditary thrombocytosis is germline mutations affecting the thrombopoietin (TPO)/TPO receptor (MPL)/JAK2 signaling axis. Here, we report one family presenting two cases with a mild thrombocytosis.
Christine Bellanné-Chantelot, Christine Bellanné-Chantelot, Matthieu Mosca, Matthieu Mosca, Matthieu Mosca, Caroline Marty, Caroline Marty, Caroline Marty, Rémi Favier, Rémi Favier, William Vainchenker, William Vainchenker, William Vainchenker, Isabelle Plo, Isabelle Plo, Isabelle Plo   +15 more
doaj   +3 more sources

Syntactic pattern matching with GraphSpider and MPL

, 2008
We present MPL (Metapattern Language), a new formalism for defining patterns over dependency-parsed text, and GraphSpider, a matching engine for extracting dependency subgraphs which match against MPL patterns. Using a regexp-like syntax, MPL allows the
Shepherd, Adrian J., Clegg, A.B.
core   +7 more sources

Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis. [PDF]

, 2021
Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALRdel52) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation of JAK-STAT signaling.
Chen, Edwin, Boyd, G., Alameer, G, Laslo, P, Boxall, Sally A, Rivera, Jeanne F, Boyd, G, Jackson, BR, Boyd, Grace, Mullally, A., Jackson, Brian R, Rivera, JF, Kent, DG, Baxter, E.J., Baxter, EJ, Kent, David Geoffrey, Alameer, G., Nadat, F., Laslo, P., Chen, E, Mullally, Ann, Chen, E., Green, AR, Burman, E.L., Green, A.R., Burman, EL, Smyth, R, Nadat, Fatima, Smyth, R., Patel, H., Burman, Emma L, Mullally, A, Nadat, F, Patel, H, Kent, D.G., Boxall, SA, Baral, A.J., Baral, AJ, Patel, Hershna, Baral, April J, Jackson, B.R., Baxter, Joanna, Smyth, Rachael, Alameer, Ghadah, Boxall, S.A., Green, Anthony R, Rivera, J.F., Laslo, Peter   +47 more
core   +4 more sources

Regulation of thrombopoietin receptor expression and function [PDF]

, 2004
Of the many cells in the body, the hematopoietic cells are among those with the highest rate of self-renewal and turnover. The production and destruction of these cells are tightly controlled by a number of hematopoietic growth factors, in particular by ...
Coers, Jörn
core   +1 more source

Genetic studies of familial myeloproliferative disorders [PDF]

, 2007
Hereditary thrombocythemia (HT) is an autosomal dominant disorder with clinical features resembling sporadic essential thrombocythemia. HT families share similar clinical symptoms caused by heterogeneous genetic alterations.
Liu, Kun
core   +1 more source

Genomics of clonal evolution in a rare essential thrombocythemia with coexisting Type 2 CALR and MPL S204P mutations

Platelets, 2023
Essential thrombocythemia (ET) with double driver mutations is a rare disease. ET patients with both MPL and Type 1 CALR mutations have been reported.
Jing Wang, Wenjing Fu, Wenqiang Bao, Wenyu Gong, Shiyun Xu, Chun Ling, Qichuan Jin, Qiguo Zhang   +7 more
doaj   +1 more source

Pemetaan Zona Kerentanan Bahaya Kebakaran Sebagai Upaya Mitigasi Awal Kebakaran Kota Yogyakarta

Dinamika Rekayasa, 2019
Kota Yogyakarta merupakan kota padat penduduk dengan sejumlah aktivitas manusia yang sangat  padat, serta konstruksi bangunan dengan potensi bahaya kebakaran yang tinggi, oleh karena itu perlu adanya upaya pemetaan sebagai langkah awal dari upaya ...
Aulia Nur Mustaqiman, Kurniawan Kurniawan, Yuliana Farkhah   +2 more
doaj   +1 more source

The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity [PDF]

, 2010
The classical myeloproliferative disorders (MPD), comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling ...

core   +2 more sources