Results 41 to 50 of about 29,777 (280)

Coherent coupling of single molecules to on-chip ring resonators

New Journal of Physics, 2019
We report on cryogenic coupling of organic molecules to ring microresonators obtained by looping subwavelength waveguides (nanoguides). We discuss fabrication and characterization of the chip-based nanophotonic elements which yield a resonator finesse in
Dominik Rattenbacher, Alexey Shkarin, Jan Renger, Tobias Utikal, Stephan Götzinger, Vahid Sandoghdar   +5 more
doaj   +1 more source

Pore-Scale Modeling of Microporous Layer for Proton Exchange Membrane Fuel Cell: Effective Transport Properties

Membranes, 2023
A microporous layer (MPL) is a transition layer with a porous material structure, located between the gas diffusion layer (GDL) and catalyst layer (CL) in a proton exchange membrane fuel cell (PEMFC).
Heng Zhang, Xuanyu Shao, Zhigang Zhan, Mrittunjoy Sarker, Pang-Chieh Sui, Po-Ya Abel Chuang, Mu Pan   +6 more
doaj   +1 more source

Data accompanying the GitHub repository bartonlab/paper-MPL-inference

, 2019
<p>This dataset contains data from simulations and analysis of within-host HIV-1 evolution that accompany the GitHub repository bartonlab/paper-MPL-inference.
Muhammad S. Sohail, Muhammad S. Sohail (6945914), Raymond H. Y. Louie, Raymond H. Y. Louie (6945917), John P. Barton (610834), John P. Barton, Matthew R. McKay (5727938), Matthew R. McKay   +7 more
core   +1 more source

Structure and Transcription of the Human c-mpl Gene (MPL)

Genomics, 1994
The human c-mpl proto-oncogene encodes a member of the cytokine receptor superfamily, expressed mainly in CD 34-positive hematopoietic progenitors and in the megakaryocytic lineage. To investigate the elements required for this tissue-specific expression, we cloned the human c-mpl gene (MPL) as well as the 5' end of the mouse gene. The human c-mpl gene
V, Mignotte, I, Vigon, E, Boucher de Crèvecoeur, P H, Roméo, V, Lemarchandel, S, Chrétien   +5 more
openaire   +2 more sources

MODEL PROBLEM BASED LEARNING (PBL) PADA PEMBELAJARAN MATEMATIKA

Jurnal E-DuMath, 2018
This study aims to determine the difference in the mean learning outcomes of mathematics students through model of problem-based learning with the mean mathematics student learning outcomes through the model jigsaw cooperative, and which is higher than ...
Yunni Arnidha, Noerhasmalina Noerhasmalina   +1 more
doaj   +1 more source

Local TLR4 stimulation augments in situ vaccination induced via local radiation and anti-CTLA-4 checkpoint blockade through induction of CD8 T-cell independent Th1 polarization

Journal for ImmunoTherapy of Cancer, 2022
Background Radiation therapy (RT) has been demonstrated to generate an in situ vaccination (ISV) effect in murine models and in patients with cancer; however, this has not routinely translated into enhanced clinical response to immune checkpoint ...
Zachary S Morris, KyungMann Kim, Paul M Sondel, Paul A Clark, Raghava N Sriramaneni, Won Jong Jin, Justin C Jagodinsky, Amber M Bates, Ishan Chakravarty, Thomas C Havighurst, Erin J Nystuen   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice

Journal of Neuroinflammation, 2022
Background Innate immune pre-stimulation can prevent the development of depression-like behaviors in chronically stressed mice; however, whether the same stimulation prevents the development of anxiety-like behaviors in animals remains unclear.
Fu Li, Haitao Xiang, Yue Gu, Ting Ye, Xu Lu, Chao Huang   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source