Results 21 to 30 of about 12,091 (231)

CALR-positive essential thrombocythaemia preceded by immune thrombocytopaenia [PDF]

, 2021
Presentation: The patient initially presented with gum bleeding and a petechial rash. Diagnosis: The patient was found to be severely thrombocytopaenic and bone marrow biopsy showed a marked excess of megakaryocytes consistent with a diagnosis of immune ...
Barrett, A., Cahill, Mary R.
core   +1 more source

JAK2/STAT5 Pathway Mutation Frequencies in South African BCR/ABL Negative MPN Patients

Hematology/Oncology and Stem Cell Therapy, 2023
Background: Mutations in JAK2/STAT5 proliferation pathway genes are key in the diagnosis of myeloproliferative neoplasms (MPNBCR/ABLneg), with JAK2V617F being found in 50-97% of MPNBCR/ABLneg subtypes.
Karen L. Shires, Adriana J. Rust, Rushil Harryparsad, Justin A. Coburn, Ruth E. Gopie   +4 more
doaj   +1 more source

CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response

, 2022
Cancer is driven by somatic mutations that provide a fitness advantage. While targeted therapies often focus on the mutated gene or its direct downstream effectors, imbalances brought on by cell-state alterations may also confer unique vulnerabilities ...
Olga Pozdnyakova (3585275), Ann Mullally (558873), Shruti Bhatt (11715440), Angel Guerra-Moreno (843004), Fatima Al-Shahrour (5649727), Steven A Carr (13555213), Anna S Nam (20644592), Jonas S Jutzi (20644577), Benjamin Rolles (20644589), Peter van Galen (9129860), Samuel A Myers (13814209), Maria Jose Jimenez-Santos (20644583), Yuning Hong (9484979), Jessica Hem (20644586), Anna E Marneth (20644580)   +14 more
core   +1 more source

Exposure-Response Analyses of Ropeginterferon Alfa-2b in Essential Thrombocythemia. [PDF]

J Clin Pharmacol
Abstract Ropeginterferon alfa‐2b is a new‐generation interferon therapy for the treatment of myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET). This investigation was designed to characterize its population pharmacokinetics–pharmacodynamics (PopPK‐PD) and delineate exposure–response (E‐R) relationships in ET. A population PK
Qin A, Masarova L, Chen H, Xiao Z, Jin J, Gill H, Reeves BN, Chaer FE, Kirito K, Komatsu N, Abu-Zeinah G, Shimoda K, Zagrijtschuk O, Sato T, Wu D, Wu L, Su X, Gao Y, Cui J, Zhang L, Mesa RA.   +20 more
europepmc   +2 more sources

Genomics of clonal evolution in a rare essential thrombocythemia with coexisting Type 2 CALR and MPL S204P mutations

Platelets, 2023
Essential thrombocythemia (ET) with double driver mutations is a rare disease. ET patients with both MPL and Type 1 CALR mutations have been reported.
Jing Wang, Wenjing Fu, Wenqiang Bao, Wenyu Gong, Shiyun Xu, Chun Ling, Qichuan Jin, Qiguo Zhang   +7 more
doaj   +1 more source

Materials of the II Conference “Current Issues of Diagnosis and Treatment of Ph-Negative and Ph-Positive Myeloproliferative Neoplasms” (March 15–16, 2019; National Research Center for Hematology, Moscow)

Клиническая онкогематология, 2020
The publication contains materials of the reports presented at the II Conference “Current Issues of Diagnosis and Treatment of Ph-Negative and Ph-Positive Myeloproliferative Neoplasms” held from 15 to 16 March 2019 at the National Research Center for ...
A. L. Melikyan, A. G. Turkina, Irina Nikolaevna Subortseva, E. Yu. Chelysheva, A. M. Kovrigina, V. A. Shuvaev, V. V. Baikov, O. Yu. Vinogradova, S. M. Kulikov, A. N. Petrova, A. V. Bykova, A.-P. A. Poshivai, Yu. Yu. Vlasova, M. M. Chukavina, O. D. Serdyuk, K. V. Naumova, N. T. Siordiya, N. S. Lazorko, R. V. Grozov, E. I. Mullo, A. S. Maksimova, O. M. Senderova, O. V. Kanya, M. S. Fominykh, D. I. Shikhbabaeva, E. A. Belyakova, I. S. Martynkevich, L. B. Polushkina, M. N. Zenina, E. V. Efremova, V. I. Rugal, L. P. Papayan, N. E. Korsakova, O. Yu. Matvienko, E. B. Syrtseva, S. V. Gappoev, M. V. Barabanshchikova, M. O. Ivanova, K. D. Kaplanov, E. S. Rogova, K. B. Trizna, A. S. Zhevnyak, O. E. Ochirova, A. A. Shakhaeva, A. S. Lyamkina, I. P. Mikhno, Yu. B. Chernykh, T. V. Chudanova, I. N. Kontievskii, N. N. Glonina, M. V. Burundukova   +50 more
doaj   +1 more source

Secreted calreticulin mutants subvert anticancer immunosurveillance

OncoImmunology, 2020
Mutations of the gene coding for calreticulin (CALR) that cause the loss of the C-terminal KDEL motif abolish its retention in the endoplasmic reticulum and cause CALR to be secreted from cells.
Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp   +3 more
doaj   +1 more source

The Mutation Profile of Calreticulin in Patients with Myeloproliferative Neoplasms and Acute Leukemia

Turkish Journal of Hematology, 2016
Objective: Calreticulin (CALR) plays important roles in cell proliferation, apoptosis, and immune responses. CALR mutations were described recently in Janus kinase 2 gene (JAK2)-negative or MPLnegative primary myelofibrosis (PMF) and essential ...
Jingyi Wang, Jianguo Hao, Na He, Chunyan Ji, Daoxin Ma   +4 more
doaj   +1 more source

Сравнение молекулярно-генетических методов выявления мутаций в гене CALR при миелопролиферативных заболеваниях [PDF]

, 2019
Molecular genetic detection of CALR gene somatic mutations is required for myeloproliferative neoplasms diagnosis and treatment according to the novel WHO clinical recommendations.
Ю. П. Финашутина, Yu. P. Finashutina, А. А. Турба, А. А. Солодовник, Н. Н. Касаткина, Л. А. Кесаева, V. A. Misyurin, I. N. Soldatova, O. N. Solopova, A. Yu. Bulanov, V. V. Tikhonova, A. A. Turba, N. N. Kasatkina, Е. Н. Мисюрина, N. A. Lyzhko, Н. А. Лыжко, В. В. Тихонова, О. Н. Солопова, А. В. Мисюрин, A. V. Misyurin, А. Ю. Буланов, И. Н. Солдатова, E. N. Misyurina, A. A. Solodovnik, В. А. Мисюрин, L. A. Kesaeva   +25 more
core   +1 more source

Calreticulin Blockade Attenuates Murine Acute Lung Injury by Inducing Polarization of M2 Subtype Macrophages

Frontiers in Immunology, 2020
Calreticulin (CALR) has anti-tumor effects by increasing dendritic cell maturation and tumor antigen presentation. However, whether CALR affects macrophages and modulates progression of acute respiratory distress syndrome/acute lung injury (ARDS/ALI ...
Zhilong Jiang, Zhihong Chen, Lu Hu, Lin Qiu, Lei Zhu   +4 more
doaj   +1 more source