Results 11 to 20 of about 12,091 (231)
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2017 Calreticulin (CALR) is a multifunctional protein involved in molecular chaperoning and calcium homeostasis. CALR has also been associated with proliferation, cell cycle progression, migration, invasion and anoikis resistance in cancer cells.
Campos, Paula de Melo +2 more
core +4 more sources
Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis [PDF]
Blood Cancer Journal, 2019 Shide, K., Kameda, T., Kamiunten, A. et al. Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis. Blood Cancer J. 9, 42 (2019).
Kitanaka, Akira +22 more
core +6 more sources
Mutant CALR functions: gains and losses. [PDF]
Blood, 2020 In this issue of Blood, Shide et al separate the roles of loss of a normal CALR allele and gain of a mutant CALR allele in CALR-driven essential thrombocythemia (ET)
Anthony R. Green, Daniel Prins
core +5 more sources
The contemporary approach to CALR-positive myeloproliferative neoplasms [PDF]
International Journal of Molecular Sciences, 2021 CALR mutations are a revolutionary discovery and represent an important hallmark of myeloproliferative neoplasms (MPN), especially essential thrombocythemia and primary myelofibrosis.
Sever, Matjaž +7 more
core +4 more sources
Frequencies, Laboratory Features, and Granulocyte Activation in Chinese Patients with CALR-Mutated Myeloproliferative Neoplasms. [PDF]
PLoS ONE, 2015 Somatic mutations in the CALR gene have been recently identified as acquired alterations in myeloproliferative neoplasms (MPNs). In this study, we evaluated mutation frequencies, laboratory features, and granulocyte activation in Chinese patients with ...
Haixiu Guo +14 more
doaj +2 more sources
Analysis of phenotype and outcome in essential thrombocythemia with CALR or JAK2 mutations [PDF]
Haematologica, 2015 The JAK2 V617F mutation, the thrombopoietin receptor MPL W515K/L mutation and calreticulin (CALR) mutations are mutually exclusive in essential thrombocythemia and support a novel molecular categorization of essential thrombocythemia.
Carla Al Assaf +12 more
doaj +2 more sources
CALR mutation profile in Irish patients with myeloproliferative neoplasms [PDF]
Hematology/Oncology and Stem Cell Therapy, 2016 Insertion and/or deletion mutations of the CALR gene have recently been demonstrated to be the second most common driver mutations in the myeloproliferative neoplasms (MPNs) of essential thrombocythemia (ET) and primary myelofibrosis (PMF).
Karl Haslam +6 more
doaj +2 more sources
CalR is an activator of biofilm formation in Vibrio parahaemolyticus
Applied and Environmental MicrobiologyVibrio parahaemolyticus, the leading cause of seafood-associated gastroenteritis, often exists in a biofilm state. Biofilm formation in this bacterium is regulated by a complex network of factors, including the second messenger c-di-GMP.
Jingyang Chang +8 more
doaj +2 more sources
Artificial Cells, Nanomedicine, and Biotechnology, 2019 The aim of this study is to investigate the effect of miR-148b on cell proliferation and migration of Schwann cells and explore its mechanism. The miR-148b group, miR-con group and the anti-miR-148b group, anti-miR-con group, si-con group, si-CALR group,
Zhenyu Zhou +3 more
doaj +2 more sources
Pediatric Essential Thrombocythemia With a Novel <i>CALR</i> Mutation: A Case Report. [PDF]
EJHaemABSTRACT Pediatric essential thrombocythemia (ET) is extremely rare and frequently lacks identifiable driver mutations. We report a case of a 5‐year‐old male with ET harboring a novel CALR exon 9 frameshift mutation complicated by acquired von Willebrand syndrome.
Tsuji K +10 more
europepmc +2 more sources