Results 81 to 90 of about 273,588 (361)

Data_Sheet_2_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.PDF

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Decarbromodiphenyl ether (BDE-209) exposure promotes migration of triple-negative breast cancer cells through STAT3 signaling pathway

陆军军医大学学报, 2023
Objective To explore the exposure of decarbromo diphenyl ether (BDE-209), a new persistent organic pollutant (POP) with the highest level in human body, on the migration of triple-negative breast cancer (TNBC) cell line MDE-MB-231, and explore the ...
XIE Shangfu, LU Linming, Jiang Mengxiao, WANG Qi   +3 more
doaj   +1 more source

Data_Sheet_3_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.PDF

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

The STAT3-DNMT1 connection [PDF]

JAK-STAT, 2012
Gene activity is regulated by transcriptional and epigenetic mechanisms. A paper in 2005 by Zhang et al.(1) showed that STAT3 binds to the DNA methyl transferase, DNMT1 and their data indicated that STAT3 may cause epigenetic gene silencing by targeting DNMT1 to the PTPN6 promoter. Now, a paper by Lee et al.(2) has fleshed out the mechanism.
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Table_2_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3

Open Medicine
Oral cancer constitutes a significant public health challenge, and gaining insights into the pathogenesis of oral cancer is crucial for the development of innovative therapeutic approaches. To address this objective, this study investigates the impact of
Fang Jing, Li Kunshan, Zhang Liyuan, Zhang Ying, Wang Yifan, Zhang Jing   +5 more
doaj   +1 more source

Exosomal lncRNA HOTAIR Promotes the Progression and Angiogenesis of Endometriosis via the miR-761/HDAC1 Axis and Activation of STAT3-Mediated Inflammation

International Journal of Nanomedicine, 2022
Lu Zhang,1 Zitong Yu,2 Qingxi Qu,1 Xiao Li,1 Xue Lu,1 Hui Zhang1 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, 250012, People’s Republic of China; 2Department of Obstetrics, Shouguang People’s Hospital, Shouguang,
Zhang L, Yu Z, Qu Q, Li X, Lu X, Zhang H
doaj