Results 61 to 70 of about 216,448 (216)

Differential signal transducer and activator of transcription 3 (Stat3) phosphorylation in breast cancer-derived cell lines [PDF]

, 2011
Copyright information:Taken from "Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer"http://breast-cancer-research.com/content/9/3/R32Breast Cancer Research 2007;9(3):R32-R32.Published online
Hikmat Al-Ahmadie (77202), William Bornmann (77203), Marjan Berishaj (77198), Kenneth Leslie (77201), Jacqueline F Bromberg (77204), Simi Ahmed (77200), William L Gerald (60358), Sizhi Paul Gao (77199)   +7 more
core   +1 more source

ZFAS1/STAT3 axis modulates imatinib resistance of chronic myeloid leukemia cells through glucose metabolism reprogramming

Frontiers in Oncology
BackgroundChronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome (chromosome 22). This cytogenetic abnormality gives rise to the BCR::ABL1 fusion gene, which encodes the constitutively
Lan Yang, Yanqiu Han
doaj   +1 more source

Quercetin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and activation of JAK2/STAT3 pathway: A target based networking pharmacology approach

Frontiers in Pharmacology, 2022
The rapid growth of vascular smooth muscle cells (VSMCs) represents crucial pathological changes during the development of hypertensive vascular remodeling. Although quercetin exhibits significantly therapeutic effects on antihypertension, the systematic
Di Wang, Di Wang, Di Wang, Farman Ali, Farman Ali, Farman Ali, Huixin Liu, Huixin Liu, Huixin Liu, Ying Cheng, Ying Cheng, Ying Cheng, Meizhu Wu, Meizhu Wu, Meizhu Wu, Muhammad Zubair Saleem, Huifang Zheng, Huifang Zheng, Huifang Zheng, Lihui Wei, Lihui Wei, Lihui Wei, Jiangfeng Chu, Jiangfeng Chu, Jiangfeng Chu, Qiurong Xie, Qiurong Xie, Qiurong Xie, Aling Shen, Aling Shen, Aling Shen, Jun Peng, Jun Peng, Jun Peng   +33 more
doaj   +1 more source

Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3

PLOS ONE, 2015
Activated STAT3 plays an important role in oncogenesis by stimulating cell proliferation and resisting apoptosis. STAT3 therefore is an attractive target for cancer therapy. We have screened a traditional Chinese herb medicine compound library and found Eriocalyxin B (EB), a diterpenoid from Isodon eriocalyx, as a specific inhibitor of STAT3.
Xiaokui Yu, Li He, Peng Cao, Qiang Yu
openaire   +4 more sources

The R(h)oads to Stat3: Stat3 activation by the Rho GTPases [PDF]

Experimental Cell Research, 2011
The signal transducer and activator of transcription-3 (Stat3) is a member of the STAT family of cytoplasmic transcription factors. Overactivation of Stat3 is detected with high frequency in human cancer and is considered a molecular abnormality that supports the tumor phenotype. Despite concerted investigative efforts, the molecular mechanisms leading
Raptis, Leda, Arulanandam, Rozanne, Geletu, Mulu, Turkson, James   +3 more
openaire   +3 more sources

Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury

Frontiers in Immunology
IntroductionNaringenin (Nar), a common flavanone abundant in citrus fruits and tomatoes, is common in diets. Although Nar can alleviate intestinal ischemia/reperfusion injury (IRI), the exact anti-inflammatory mechanisms are unclear and require further ...
Min Hou, Yanshun Wang, Suheng Chen, Zhiguo Tan, Jie Liu, Xiaoxi Li, Xiaoxia Han, Zaiqi Yang, Yufang Leng, Yufang Leng   +9 more
doaj   +1 more source

Decarbromodiphenyl ether (BDE-209) exposure promotes migration of triple-negative breast cancer cells through STAT3 signaling pathway

陆军军医大学学报, 2023
Objective To explore the exposure of decarbromo diphenyl ether (BDE-209), a new persistent organic pollutant (POP) with the highest level in human body, on the migration of triple-negative breast cancer (TNBC) cell line MDE-MB-231, and explore the ...
XIE Shangfu, LU Linming, Jiang Mengxiao, WANG Qi   +3 more
doaj   +1 more source

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors [PDF]

Nature Medicine, 2010
Interleukin-6 (IL-6)-Janus kinase (JAK) signaling is viewed as crucial for persistent signal transducer and activator of transcription-3 (STAT3) activation in cancer. However, IL-6-induced STAT3 activation is normally transient. Here we identify a key mechanism for persistent STAT3 activation in tumor cells and the tumor microenvironment.
Lee, Heehyoung, Deng, Jiehui, Kujawski, Maciej, Yang, Chunmei, Liu, Yong, Herrmann, Andreas, Kortylewski, Marcin, Horne, David, Somlo, George, Forman, Stephen, Jove, Richard, Yu, Hua   +11 more
openaire   +2 more sources

Psoriasis: A STAT3-Centric View [PDF]

International Journal of Molecular Sciences, 2018
Signal Transducer and Activator of Transcription (STAT)3 has recently emerged as a key player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory conditions. Indeed, STAT3 hyperactivation has been reported in virtually every cell type involved in disease initiation and maintenance, and this factor mediates the signal of ...
Calautti, Enzo, Avalle, Lidia, Poli, Valeria   +2 more
openaire   +4 more sources

Interleukin-37 mediates the anti-oral tumor activity in oral cancer through STAT3

Open Medicine
Oral cancer constitutes a significant public health challenge, and gaining insights into the pathogenesis of oral cancer is crucial for the development of innovative therapeutic approaches. To address this objective, this study investigates the impact of
Fang Jing, Li Kunshan, Zhang Liyuan, Zhang Ying, Wang Yifan, Zhang Jing   +5 more
doaj   +1 more source