Results 61 to 70 of about 229,822 (315)

Quercetin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and activation of JAK2/STAT3 pathway: A target based networking pharmacology approach

Frontiers in Pharmacology, 2022
The rapid growth of vascular smooth muscle cells (VSMCs) represents crucial pathological changes during the development of hypertensive vascular remodeling. Although quercetin exhibits significantly therapeutic effects on antihypertension, the systematic
Di Wang, Di Wang, Di Wang, Farman Ali, Farman Ali, Farman Ali, Huixin Liu, Huixin Liu, Huixin Liu, Ying Cheng, Ying Cheng, Ying Cheng, Meizhu Wu, Meizhu Wu, Meizhu Wu, Muhammad Zubair Saleem, Huifang Zheng, Huifang Zheng, Huifang Zheng, Lihui Wei, Lihui Wei, Lihui Wei, Jiangfeng Chu, Jiangfeng Chu, Jiangfeng Chu, Qiurong Xie, Qiurong Xie, Qiurong Xie, Aling Shen, Aling Shen, Aling Shen, Jun Peng, Jun Peng, Jun Peng   +33 more
doaj   +1 more source

Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3

PLOS ONE, 2015
Activated STAT3 plays an important role in oncogenesis by stimulating cell proliferation and resisting apoptosis. STAT3 therefore is an attractive target for cancer therapy. We have screened a traditional Chinese herb medicine compound library and found Eriocalyxin B (EB), a diterpenoid from Isodon eriocalyx, as a specific inhibitor of STAT3.
Xiaokui Yu, Li He, Peng Cao, Qiang Yu
openaire   +4 more sources

The R(h)oads to Stat3: Stat3 activation by the Rho GTPases [PDF]

Experimental Cell Research, 2011
The signal transducer and activator of transcription-3 (Stat3) is a member of the STAT family of cytoplasmic transcription factors. Overactivation of Stat3 is detected with high frequency in human cancer and is considered a molecular abnormality that supports the tumor phenotype. Despite concerted investigative efforts, the molecular mechanisms leading
Raptis, Leda, Arulanandam, Rozanne, Geletu, Mulu, Turkson, James   +3 more
openaire   +3 more sources

STAT3-dependent upregulation of IGF2 in TSC2-null cells.

, 2018
(A) Re-expression of TSC2 (TSC2++) in TSC2-null LAM 102 (TSC2—) cells decreased STAT3 expression and activation. (B) siRNA-induced knockdown of STAT3 decreased STAT3 levels in TSC2— cells.
Maya Shumyatcher (5215781), Stella K. Hur (4875787), Vera P. Krymskaya (188111), Ryan Rue (5215775), Blanca E. Himes (153105), Lurong Lian (436174), Marisa S. Bartolomei (328035), Kseniya Obraztsova (5215778), Elena N. Atochina-Vasserman (511732), Jilly F. Evans (2138905)   +9 more
core   +1 more source

Table_4_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.xlsx

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

Network pharmacology to explore the novel anti-inflammatory mechanism of naringenin in intestinal ischemia/reperfusion injury

Frontiers in Immunology
IntroductionNaringenin (Nar), a common flavanone abundant in citrus fruits and tomatoes, is common in diets. Although Nar can alleviate intestinal ischemia/reperfusion injury (IRI), the exact anti-inflammatory mechanisms are unclear and require further ...
Min Hou, Yanshun Wang, Suheng Chen, Zhiguo Tan, Jie Liu, Xiaoxi Li, Xiaoxia Han, Zaiqi Yang, Yufang Leng, Yufang Leng   +9 more
doaj   +1 more source

Data_Sheet_3_The Food Additive β-Caryophyllene Exerts Its Neuroprotective Effects Through the JAK2-STAT3-BACE1 Pathway.PDF

, 2022
Despite extensive research on Alzheimer’s disease (AD), its diagnosis and treatment remain challenging, and no effective therapies are currently available.
Shuo Huang (624671), Haichao Jin (12158421), Ziqian Liao (12158418), Qiaoyan Huang (12158412), Yiming Liu (765457), Yujia Zhang (757462), Jie Pang (1675537), Liting Ji (12158424), Sichen Wang (12158415), Xiao Hong (95588), Changyu Li (309650), Qingcheng Wang (9977016), Qing Shen (1274367)   +12 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Decarbromodiphenyl ether (BDE-209) exposure promotes migration of triple-negative breast cancer cells through STAT3 signaling pathway

陆军军医大学学报, 2023
Objective To explore the exposure of decarbromo diphenyl ether (BDE-209), a new persistent organic pollutant (POP) with the highest level in human body, on the migration of triple-negative breast cancer (TNBC) cell line MDE-MB-231, and explore the ...
XIE Shangfu, LU Linming, Jiang Mengxiao, WANG Qi   +3 more
doaj   +1 more source

Psoriasis: A STAT3-Centric View [PDF]

International Journal of Molecular Sciences, 2018
Signal Transducer and Activator of Transcription (STAT)3 has recently emerged as a key player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory conditions. Indeed, STAT3 hyperactivation has been reported in virtually every cell type involved in disease initiation and maintenance, and this factor mediates the signal of ...
Calautti, Enzo, Avalle, Lidia, Poli, Valeria   +2 more
openaire   +5 more sources