Results 21 to 30 of about 7,897,153 (261)
The inflammaging clock strikes IL-11! [PDF]
ImmunityChronic inflammation is considered a hallmark of aging. In a recent issue of Nature, Widjaja et al. examined genetic and pharmacologic inhibition of interleukin (IL)-11 on aging pathology and found that inhibiting IL-11 signaling increases lifespan and healthspan in mice.
Khan S, Chang V, Winer DA.
europepmc +3 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Cytokines are key players in tumorigenesis and are potential targets in cancer treatment. Although IL-6 has attracted considerable attention, interleukin 11 (IL-11), another member of the IL-6 family, has long been overlooked, and little
Meng Zhao +6 more
doaj +2 more sources
The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review [PDF]
Journal of Cardiovascular Development and DiseaseFibrosis is one of the main factors that impair the function of many organs. In the heart, fibrosis leads to contractile dysfunction and arrhythmias, which are important in the development of heart failure.
Yarlla Loyane Lira Braga +8 more
doaj +2 more sources
Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor
Cell Reports, 2016 Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and ...
Niloufar Monhasery +13 more
doaj +2 more sources
Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis [PDF]
Molecular MedicineReduced lymphoid enhancer-binding factor 1 (LEF1) expression in patients with adenomyosis during the mid-secretory phase leads to impaired endometrial receptivity, affecting embryo implantation. This study investigated the molecular mechanisms underlying
Jingru Duan +8 more
doaj +2 more sources
Zac1 regulates IL-11 expression in osteoarthritis [PDF]
Oncotarget, 2018 Interleukin (IL)-11, a member of the IL-6 family of cytokines, exerts pleiotropic effects under normal and various disease conditions. We assessed IL-11 expression regulation and the IL-11/IL-6 ratio in osteoarthritis (OA) to better guide clinical ...
Chun-Lin Kuo +4 more
semanticscholar +3 more sources
Interleukin-11/IL-11 Receptor Promotes Glioblastoma Cell Proliferation, Epithelial–Mesenchymal Transition, and Invasion [PDF]
Brain SciencesGlioblastoma is highly proliferative and invasive. However, the regulatory cytokine networks that promote glioblastoma cell proliferation and invasion into other areas of the brain are not fully defined.
Sarah F. Stuart +9 more
doaj +2 more sources
IL-11 promotes Ang II-induced autophagy inhibition and mitochondrial dysfunction in atrial fibroblasts [PDF]
Open Life SciencesWang Jun +4 more
doaj +2 more sources
International Journal of Molecular Sciences, 2021 Cardiac fibrosis is a pathological process associated with the development of heart failure. TGF-β and WNT signaling have been implicated in pathogenesis of cardiac fibrosis, however, little is known about molecular cross-talk between these two pathways.
E. Działo +5 more
semanticscholar +1 more source
Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors
Frontiers in Cell and Developmental Biology, 2021 Interleukin-6 (IL-6) is the name-giving cytokine of a family of eleven members, including IL-6, CNTF, LIF, and IL-27. IL-6 was first recognized as a B-cell stimulating factor but we now know that the cytokine plays a pivotal role in the orchestration of ...
Dirk Schmidt-Arras, Stefan Rose-John
doaj +1 more source