Results 21 to 30 of about 11,450,124 (231)

IL-11 MD Trajectory and PSF files

, 2023
Related to Figure 6D and Supplementary Figure 13 in Metcalfe et al. Nature Communications 2023. Dataset includes trajectory files (dcd files), IL-11 PSF and PDB files, and PDB files corresponding to the first and last frame in the trajectory.
Riley Metcalfe (16892142)
core   +1 more source

Two N-Linked Glycans Differentially Control Maturation, Trafficking and Proteolysis, but not Activity of the IL-11 Receptor

Cellular Physiology and Biochemistry, 2018
Background/Aims: The cytokine interleukin-11 (IL-11) has important pro- and anti-inflammatory functions. It activates its target cells through binding to the IL-11 receptor (IL-11R), and the IL-11/IL-11R complex recruits a homodimer of glycoprotein 130 ...
Maria Agthe, Yvonne Garbers, Joachim Grötzinger, Christoph Garbers   +3 more
doaj   +1 more source

BALB/c mice deficient in CD4(+) T cell IL-4R alpha expression control Leishmania mexicana load although female but not male mice develop a healer phenotype [PDF]

, 2011
Immunologically intact BALB/c mice infected with Leishmania mexicana develop non-healing progressively growing lesions associated with a biased Th2 response while similarly infected IL-4R alpha-deficient mice fail to develop lesions and develop a robust ...
Owain R Millington, Bryson Karen J., Millington Owain R., McGachy, Adrienneh H., Brombacher, F, Mokgethi Thabang, Bryson, Karen, H. Adrienne McGachy, Owain R. Millington, McGachy, Adrienne, H Adrienne McGachy, James Alexander, Mokgethi, T, Karen J Bryson, Alexander, James, Brombacher Frank, Frank Brombacher, Alexander James, McGachy, Helen, Bryson, Karen J., Thabang Mokgethi, Millington, Owain R., Millington, Owain, Brombacher, Frank, Mokgethi, Thabang, Bryson, Karen J, Karen J. Bryson, McGachy, H Adrienne, McGachy H. Adrienne, Millington, Owain R   +29 more
core   +4 more sources

Differential expression of cytokines and receptor expression during anoxic growth

BMC Research Notes, 2018
Objective Cell density in tumor cell three dimensional (3D) cultures affects secretome expression of components. A microenvironment characteristic shared by high-density 3D cell culture and in vivo tumor masses is poor oxygenation, with anoxia being a ...
Balbina J. Plotkin, Ira M. Sigar, Julie A. Swartzendruber, Amber Kaminski, James Davis   +4 more
doaj   +1 more source

Pilot study on molecular quantitation and sequencing of endometrial cytokines gene expression and their effect on the outcome of in vitro fertilization (IVF) cycle

Journal of Advanced Research, 2014
Human trophoblast invasion and differentiation are essential for successful pregnancy outcome. The molecular mechanisms, however, are poorly understood. Interleukin (IL)-11, a cytokine, regulates endometrial epithelial cell adhesion.
D. Sabry, O. Nouh, S. Marzouk, A. Hassouna   +3 more
doaj   +1 more source

Upregulation of IL-11, an IL-6 Family Cytokine, Promotes Tumor Progression and Correlates with Poor Prognosis in Non-Small Cell Lung Cancer

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cytokines are key players in tumorigenesis and are potential targets in cancer treatment. Although IL-6 has attracted considerable attention, interleukin 11 (IL-11), another member of the IL-6 family, has long been overlooked, and little
Meng Zhao, Yahui Liu, Ran Liu, Jin Qi, Yongwang Hou, Jiao Chang, Li Ren   +6 more
doaj   +1 more source

YAP promotes the malignancy of endometrial cancer cells via regulation of IL-6 and IL-11

Molecular Medicine, 2019
Background Emerging evidence shows that Hippo signal pathways can regulate the progression of various cancer. While the roles of Yes-associated protein (YAP), the key transducer of Hippo signals, in the development of endometrial cancer (EC) are rarely ...
Jing Wang, Tiefang Song, Suiyang Zhou, Xianchao Kong   +3 more
doaj   +1 more source

IL-11 Mutein MD Trajectory and PSF files

, 2023
Related to Figure 6D and Supplementary Figure 13 in Metcalfe et al. Nature Communications 2023. Dataset includes trajectory files (dcd files), IL-11 Mutein PSF and PDB files, and PDB files corresponding to the first and last frame in the trajectory.
Riley Metcalfe (16892142)
core   +1 more source

Interleukin-11 disrupts alveolar epithelial progenitor function

ERJ Open Research, 2023
Background Interleukin-11 (IL-11) is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF), since IL-11 induces myofibroblast differentiation and stimulates their excessive collagen deposition in the lung.
Rosa K. Kortekaas, Kerstin E. Geillinger-Kästle, Theo Borghuis, Kaoutar Belharch, Megan Webster, Wim Timens, Janette K. Burgess, Reinoud Gosens   +7 more
doaj   +1 more source

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Cell Reports, 2016
Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and ...
Niloufar Monhasery, Jens Moll, Carly Cuman, Manuel Franke, Larissa Lamertz, Rebecca Nitz, Boris Görg, Dieter Häussinger, Juliane Lokau, Doreen M. Floss, Roland Piekorz, Eva Dimitriadis, Christoph Garbers, Jürgen Scheller   +13 more
doaj   +1 more source