Results 21 to 30 of about 1,613,518 (229)

Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy

Human Vaccines & Immunotherapeutics, 2020
The interleukin 6 (IL6) family of proteins regulate important cellular processes and act through a variety of signaling pathways via a shared gp130 receptor.
Anissa A. Widjaja, Sonia P. Chothani, Stuart A. Cook   +2 more
doaj   +1 more source

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11

Frontiers in Immunology, 2020
Cytokines are small signaling proteins that have central roles in inflammation and cell survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty cytokines have been identified. Amongst these is interleukin (IL)
Riley D. Metcalfe, Tracy L. Putoczki, Tracy L. Putoczki, Michael D. W. Griffin   +3 more
doaj   +1 more source

Interleukin (IL)-11 Is Involved in the Functional Liaison between Breast Tumor Cells and the Surrounding Stroma

Biology and Life Sciences Forum, 2023
Current advances in molecular profiling methodologies and the accessibility of multi-omics datasets are paving the way toward a better understanding of heterogeneous diseases, including breast cancer (BC).
Marianna Talia, Francesca Cirillo, Domenica Scordamaglia, Maria Francesca Santolla, Asia Spinelli, Salvatore De Rosis, Lucia Muglia, Azzurra Zicarelli, Anna Maria Miglietta, Marcello Maggiolini, Rosamaria Lappano   +10 more
doaj   +1 more source

IL-11 is a crucial determinant of cardiovascular fibrosis [PDF]

Nature, 2017
Fibrosis is a common pathology in cardiovascular disease. In the heart, fibrosis causes mechanical and electrical dysfunction and in the kidney, it predicts the onset of renal failure. Transforming growth factor β1 (TGFβ1) is the principal pro-fibrotic factor, but its inhibition is associated with side effects due to its pleiotropic roles.
Schafer, S, Viswanathan, S, Widjaja, AA, Lim, W-W, Moreno-Moral, A, DeLaughter, DM, Ng, B, Patone, G, Chow, K, Khin, E, Tan, J, Chothani, SP, Ye, L, Rackham, OJL, Ko, NSJ, Sahib, NE, Pua, CJ, Zhen, NTG, Xie, C, Wang, M, Maatz, H, Lim, S, Saar, K, Blachut, S, Petretto, E, Schmidt, S, Putoczki, T, Guimarães-Camboa, N, Wakimoto, H, Van Heesch, S, Sigmundsson, K, Lim, SL, Soon, JL, Chao, VTT, Chua, YL, Tan, TE, Evans, SM, Loh, YJ, Jamal, MH, Ong, KK, Chua, KC, Ong, B-H, Chakaramakkil, MJ, Seidman, JG, Seidman, CE, Hubner, N, Sin, KYK, Cook, SA   +47 more
openaire   +4 more sources

Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11

Immunological Investigations, 2023
Systemic sclerosis (SSc) is a rare rheumatic disease characterized by vascular damage, dysregulated immune response, and fibrosis. Interleukin−11 (IL−11) is upregulated in SSc. This study aimed to investigate the pathological and therapeutic role of the IL−11 trans-signaling pathway in SSc.
Wenjing, Ye, Qian, Wang, Li, Zhao, Changcheng, Wang, Dandan, Zhang, Mengyu, Zhou, Fangfang, Chen, Weiguo, Wang, Zaihua, Zhu, Wenyu, Guo, Yun, Liu, Hejian, Zou, Yu, Xue   +12 more
openaire   +2 more sources

Two N-Linked Glycans Differentially Control Maturation, Trafficking and Proteolysis, but not Activity of the IL-11 Receptor

Cellular Physiology and Biochemistry, 2018
Background/Aims: The cytokine interleukin-11 (IL-11) has important pro- and anti-inflammatory functions. It activates its target cells through binding to the IL-11 receptor (IL-11R), and the IL-11/IL-11R complex recruits a homodimer of glycoprotein 130 ...
Maria Agthe, Yvonne Garbers, Joachim Grötzinger, Christoph Garbers   +3 more
doaj   +1 more source

Differential expression of cytokines and receptor expression during anoxic growth

BMC Research Notes, 2018
Objective Cell density in tumor cell three dimensional (3D) cultures affects secretome expression of components. A microenvironment characteristic shared by high-density 3D cell culture and in vivo tumor masses is poor oxygenation, with anoxia being a ...
Balbina J. Plotkin, Ira M. Sigar, Julie A. Swartzendruber, Amber Kaminski, James Davis   +4 more
doaj   +1 more source

IL-11 in multiple sclerosis

Oncotarget, 2015
The clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) is the first clinically evident phase of the disease. An autoimmune response against myelin proteins is considered the key pathogenic process that initiates MS. Peripherally activated myelin-reactive T cells that transmigrate across the blood brain barrier initiate an ...
Zhang, X, Putoczki, T, Markovic-Plese, S
openaire   +3 more sources

Therapeutic Targeting of IL-11 for Chronic Lung Disease [PDF]

Trends in Pharmacological Sciences, 2021
Interleukin (IL)-11 was originally recognized as an immunomodulatory and hematopoiesis-inducing cytokine. However, although IL-11 is typically not found in healthy individuals, it is now becoming evident that IL-11 may play a role in diverse pulmonary conditions, including IPF, asthma, and lung cancer. Additionally, experimental strategies targeting IL-
Rosa K, Kortekaas, Janette K, Burgess, Roël, van Orsoy, David, Lamb, Megan, Webster, Reinoud, Gosens   +5 more
openaire   +2 more sources

Pilot study on molecular quantitation and sequencing of endometrial cytokines gene expression and their effect on the outcome of in vitro fertilization (IVF) cycle

Journal of Advanced Research, 2014
Human trophoblast invasion and differentiation are essential for successful pregnancy outcome. The molecular mechanisms, however, are poorly understood. Interleukin (IL)-11, a cytokine, regulates endometrial epithelial cell adhesion.
D. Sabry, O. Nouh, S. Marzouk, A. Hassouna   +3 more
doaj   +1 more source