IL-11 and IL-11Rα immunolocalisation at primate implantation sites supports a role for IL-11 in placentation and fetal development [PDF]
Reproductive Biology and Endocrinology, 2003 Embryo implantation, endometrial stromal cell decidualization and formation of a functional placenta are critical processes in the establishment and maintenance of pregnancy. Interleukin (IL)-11 signalling is essential for adequate decidualization in the
Stoikos C +7 more
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IL-11 promotes Ang II-induced autophagy inhibition and mitochondrial dysfunction in atrial fibroblasts [PDF]
Open Life SciencesWang Jun +4 more
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Roles and mechanism of IL-11 in vascular diseases. [PDF]
Front Cardiovasc Med, 2023 Vascular diseases are the leading cause of morbidity and mortality worldwide. Therefore, effective treatment strategies that can reduce the risk of vascular diseases are urgently needed. The relationship between Interleukin-11 (IL-11) and development of vascular diseases has gained increasing attention.
Wu J, Ma W, Qiu Z, Zhou Z.
europepmc +4 more sources
The inflammaging clock strikes IL-11! [PDF]
ImmunityChronic inflammation is considered a hallmark of aging. In a recent issue of Nature, Widjaja et al. examined genetic and pharmacologic inhibition of interleukin (IL)-11 on aging pathology and found that inhibiting IL-11 signaling increases lifespan and healthspan in mice.
Khan S, Chang V, Winer DA.
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Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling. [PDF]
FASEB J, 2021 Abstract Interleukin‐11 (IL‐11) is a pleiotropic cytokine with both pro‐ and anti‐inflammatory properties. It activates its target cells via binding to the membrane‐bound IL‐11 receptor (IL‐11R), which then recruits a homodimer of the ubiquitously expressed, signal‐transducing receptor gp130. Besides this classic signaling pathway, IL‐
Koch L +7 more
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The Pathobiology of IL-11 in Kidney Disease: From Epithelial Cell to Fibroblast and Back Again. [PDF]
Am J Pathol, 2023 Widjaja AA, Cook SA.
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Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors
Frontiers in Cell and Developmental Biology, 2021 Interleukin-6 (IL-6) is the name-giving cytokine of a family of eleven members, including IL-6, CNTF, LIF, and IL-27. IL-6 was first recognized as a B-cell stimulating factor but we now know that the cytokine plays a pivotal role in the orchestration of ...
Dirk Schmidt-Arras, Stefan Rose-John
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IL-11 Regulates Autoimmune Demyelination [PDF]
The Journal of Immunology, 2009 Abstract Current therapies for the autoimmune demyelinating disease multiple sclerosis (MS) target inflammation, but do not directly address neuroprotection or lesion repair. Cytokines of the gp130 family regulate survival and differentiation of both neural and immune cells, and we recently identified expression of the family member ...
Blake T, Gurfein +6 more
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The Role of gp130 Cytokines in Tuberculosis
Cells, 2020 Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by cytokine blockers, as successfully used in the management of various chronic
Kristina Ritter +2 more
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Identification and functional characterization of Interleukin-11 in goldfish (Carassius auratus L.)
Fish and Shellfish Immunology Reports, 2023 Interleukin-11 (IL-11) is a versatile cytokine that modulates cellular differentiation and proliferation in various cell types and tissues. In this study, IL-11 gene from goldfish (Carassius auratus L.) has been identified and characterized.
Moussa Gouife +8 more
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