Results 11 to 20 of about 7,897,153 (261)

Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription. [PDF]

Aging Cell, 2022
Determining the mechanism of senescence‐associated pulmonary fibrosis is crucial for designing more effective treatments for chronic lung diseases.
Zhou J, Chen H, Wang Q, Chen S, Wang R, Wang Z, Yang C, Chen A, Zhao J, Zhou Z, Mao Z, Zuo G, Miao D, Jin J.   +13 more
europepmc   +2 more sources

Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11

Immunological Investigations, 2023
Objectives Systemic sclerosis (SSc) is a rare rheumatic disease characterized by vascular damage, dysregulated immune response, and fibrosis. Interleukin−11 (IL−11) is upregulated in SSc.
Wenjing Ye, Qian Wang, Li Zhao, Changcheng Wang, Dandan Zhang, Mengyu Zhou, Fangfang Chen, Weiguo Wang, Zaihua Zhu, Wenyu Guo, Yun Liu, H. Zou, Yu Xue   +12 more
semanticscholar   +3 more sources

IL-11 is a crucial determinant of cardiovascular fibrosis [PDF]

Nature, 2017
Fibrosis is a common pathology in cardiovascular disease. In the heart, fibrosis causes mechanical and electrical dysfunction and in the kidney, it predicts the onset of renal failure.
S. Schafer, S. Viswanathan, A. Widjaja, Wei-Wen Lim, Aida Moreno-Moral, D. DeLaughter, B. Ng, Giannino Patone, Kingsley Chow, E. Khin, Jessie Tan, S. Chothani, L. Ye, O. Rackham, Nicole S. J. Ko, N. E. Sahib, C. Pua, N. Zhen, Chen Xie, Mao Wang, H. Maatz, Shiqi Lim, K. Saar, S. Blachut, E. Petretto, Sabine Schmidt, Tracy L. Putoczki, Nuno Guimarães-Camboa, H. Wakimoto, Sebastiaan van Heesch, K. Sigmundsson, S. Lim, J. Soon, V. Chao, Y. Chua, T. Tan, S. Evans, Y. Loh, Muhammad H. Jamal, K. Ong, K. Chua, B. Ong, M. Chakaramakkil, J. Seidman, C. Seidman, N. Hubner, K. Sin, S. Cook   +47 more
semanticscholar   +5 more sources

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome. [PDF]

J Am Soc Nephrol, 2022
Significance Statement Alport syndrome (AS), a genetic disorder of the glomerular basement membrane, frequently leads to end stage renal failure.
Widjaja AA, Shekeran SG, Adami E, Ting JGW, Tan J, Viswanathan S, Lim SY, Tan PH, Hübner N, Coffman T, Cook SA.   +10 more
europepmc   +2 more sources

DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression. [PDF]

Mol Ther
The prognosis for patients with bladder cancer (BCa) with lymph node (LN) metastasis is poor, and it is not improved by current treatments. Long noncoding RNAs (lncRNAs) are involved in the pathology of various tumors, including BCa. However, the role of
Chen Z, Chen X, Xie R, Huang M, Dong W, Han J, Zhang J, Zhou Q, Li H, Huang J, Lin T.   +10 more
europepmc   +2 more sources

Emerging roles for IL-11 in inflammatory diseases.

Cytokine, 2021
Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also associated with several non-malignant inflammatory diseases where its function ...
K. Fung, Cynthia Louis, R. Metcalfe, Clara C. Kosasih, I. Wicks, M. Griffin, Tracy L. Putoczki   +6 more
semanticscholar   +4 more sources

ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice. [PDF]

Nat Commun
Cardiac macrophage contributes to the development of cardiac fibrosis, but factors that regulate cardiac macrophages transition and activation during this process remains elusive.
Zhuang T, Chen MH, Wu RX, Wang J, Hu XD, Meng T, Wu AH, Li Y, Yang YF, Lei Y, Hu DH, Li YX, Zhang L, Sun AJ, Lu W, Zhang GN, Zuo JL, Ruan CC.   +17 more
europepmc   +2 more sources

Roles and mechanism of IL-11 in vascular diseases. [PDF]

Front Cardiovasc Med, 2023
Vascular diseases are the leading cause of morbidity and mortality worldwide. Therefore, effective treatment strategies that can reduce the risk of vascular diseases are urgently needed. The relationship between Interleukin-11 (IL-11) and development of vascular diseases has gained increasing attention.
Wu J, Ma W, Qiu Z, Zhou Z.
europepmc   +4 more sources

YAP promotes the malignancy of endometrial cancer cells via regulation of IL-6 and IL-11

Molecular Medicine, 2019
Background Emerging evidence shows that Hippo signal pathways can regulate the progression of various cancer. While the roles of Yes-associated protein (YAP), the key transducer of Hippo signals, in the development of endometrial cancer (EC) are rarely ...
Jing Wang, Tiefang Song, Suiyang Zhou, Xianchao Kong   +3 more
doaj   +2 more sources

Ameliorating post-infarction myocardial fibrosis and cardiac function via ROS-responsive hydrogel-mediated IL-11 antibody delivery [PDF]

Bioactive Materials
Myocardial fibrosis, driven by fibroblast activation following myocardial infarction (MI), represents a significant pathological process contributing to heart failure progression.
Ting You, Yong Zhang, Haotao Su, Na Wang, Xinkui Zhang, Sainiwaier Anwaier, Xiang Long, Linjiang Han, Yeting Wu, Jialiang Liang, Yanzhen Yang, Changjiang Yu, Zerui Chen, Jian Liu, Tucheng Sun, Huanlei Huang, Shuoji Zhu, Nanbo Liu, Ping Zhu, Jimei Chen, Jian Zhuang, Lu Wang, Xinjian Yan   +22 more
doaj   +2 more sources