Results 31 to 40 of about 11,604 (173)

Identification of a gp130 Cytokine Receptor Critical Site Involved in Oncostatin M Response [PDF]

Journal of Biological Chemistry, 2000
Gp130 cytokine receptor is involved in the formation of multimeric functional receptors for interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor, and cardiotrophin-1. Cloning of the epitope recognized by an OSM-neutralizing anti-gp130 monoclonal antibody identified a portion of gp130 receptor ...
C, Olivier, P, Auguste, M, Chabbert, E, Lelièvre, S, Chevalier, H, Gascan   +5 more
openaire   +2 more sources

The Human GP130 Cytokine Receptor and Its Expression—an Atlas and Functional Taxonomy of Genetic Variants

Journal of Clinical Immunology, 2023
AbstractGenetic variants in IL6ST encoding the shared cytokine receptor for the IL-6 cytokine family GP130 have been associated with a diverse number of clinical phenotypes and disorders. We provide a molecular classification for 59 reported rare IL6ST pathogenic or likely pathogenic variants and additional polymorphisms.
Yin-Huai Chen, Sarah van Zon, Alex Adams, Dirk Schmidt-Arras, Arian D. J. Laurence, Holm H. Uhlig   +5 more
openaire   +2 more sources

Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor. [PDF]

PLoS ONE, 2012
Evaluation of a pathophysiological role of the interleukin-6-type cytokine oncostatin M (OSM) for human diseases has been complicated by the fact that mouse models of diseases targeting either OSM or the OSM receptor (OSMR) complex cannot fully reflect ...
Johannes Drechsler, Joachim Grötzinger, Heike M Hermanns   +2 more
doaj   +1 more source

A designer hyper interleukin 11 (H11) is a biologically active cytokine

BMC Biotechnology, 2012
Background Interleukin 11 (IL-11) is a pleiotropic cytokine with anti-apoptotic, anti-inflammatory and hematopoietic potential. The IL-11 activity is determined by the expression of the IL-11R receptor alpha (IL-11Rα) and the signal transducing subunit β
Dams-Kozlowska Hanna, Gryska Katarzyna, Kwiatkowska-Borowczyk Eliza, Izycki Dariusz, Rose-John Stefan, Mackiewicz Andrzej   +5 more
doaj   +1 more source

2‐Deoxy‐d‐glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation

Pharmacology Research & Perspectives, 2022
Anti‐proinflammatory cytokine therapies against interleukin (IL)‐6, tumor necrosis factor (TNF)‐α, and IL‐1 are major advancements in treating inflammatory diseases, especially rheumatoid arthritis.
Ikuno Uehara, Mitsuko Kajita, Atsuko Tanimura, Shigeaki Hida, Munehiko Onda, Zenya Naito, Shinsuke Taki, Nobuyuki Tanaka   +7 more
doaj   +1 more source

Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells

Frontiers in Immunology, 2019
The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies have demonstrated ...
Khalid Bin Dhuban, Khalid Bin Dhuban, Khalid Bin Dhuban, Sabrina Bartolucci, Sabrina Bartolucci, Sabrina Bartolucci, Eva d'Hennezel, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo   +9 more
doaj   +1 more source

The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes. [PDF]

PLoS ONE, 2014
Interleukin-6 (IL-6) family cytokines play important roles in cardioprotection against pathological stresses. IL-6 cytokines bind to their specific receptors and activate glycoprotein 130 (gp130), a common receptor, followed by further activation of ...
Reo Matsuo, Hirofumi Morihara, Tomomi Mohri, Shiho Murasawa, Kana Takewaki, Hiroyuki Nakayama, Makiko Maeda, Yasushi Fujio   +7 more
doaj   +1 more source

The signal transducer gp130: Solution structure of the carboxy‐terminal domain of the cytokine receptor homology region [PDF]

Protein Science, 1999
AbstractThe transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin‐6‐type cytokines. It is a member of the cytokine‐receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine‐binding module defined by a set of four conserved ...
KERNEBECK, Thomas, Pflanz, Stefan, Heinrich, Peter, Wollmer, Axel, Grötzinger, Joachim, Müller-Newen, Gerhard, Kurapkat, Günther, Grzesiek, Stephan, Scheek, Ruud M., Dijkstra, Klaas   +9 more
openaire   +4 more sources

STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis

Biomedicines, 2021
The intestinal epithelium provides a barrier against commensal and pathogenic microorganisms. Barrier dysfunction promotes chronic inflammation, which can drive the pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC).
Lokman Pang, Jennifer Huynh, Mariah G. Alorro, Xia Li, Matthias Ernst, Ashwini L. Chand   +5 more
doaj   +1 more source

The Role of gp130 Cytokines in Tuberculosis

Cells, 2020
Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by cytokine blockers, as successfully used in the management of various chronic
Kristina Ritter, Jasmin Rousseau, Christoph Hölscher   +2 more
doaj   +1 more source