Results 51 to 60 of about 11,604 (173)

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Interleukin-6 signalling in health and disease [version 1; peer review: 3 approved]

F1000Research, 2020
Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 receptor, which is not signalling competent.
Stefan Rose-John
doaj   +1 more source

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 [PDF]

Proceedings of the National Academy of Sciences, 2000
Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among others, the common receptor subunit gp130. The SH2 domain of SOCS-3 has been shown to be essential for this inhibitory activity, and we have used a quantitative binding analysis of SOCS-3 to ...
S E, Nicholson, D, De Souza, L J, Fabri, J, Corbin, T A, Willson, J G, Zhang, A, Silva, M, Asimakis, A, Farley, A D, Nash, D, Metcalf, D J, Hilton, N A, Nicola, M, Baca   +13 more
openaire   +2 more sources

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells

Blood, 2005
In vitro studies suggest that bone marrow endothelial cells contribute to multilineage hematopoiesis, but this function has not been studied in vivo. We used a Cre/loxP-mediated recombination to produce mice that lacked the cytokine receptor subunit gp130 in hematopoietic and endothelial cells.
Longbiao, Yao, Takafumi, Yokota, Lijun, Xia, Paul W, Kincade, Rodger P, McEver   +4 more
openaire   +3 more sources

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Nature Communications
IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses.
Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck   +8 more
doaj   +1 more source

An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma

Bioengineering & Translational Medicine, 2023
The cytokine interleukin (IL)‐11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention.
Brianna J. McIntosh, Griffin G. Hartmann, Sean A. Yamada‐Hunter, Phillip Liu, Camille F. Williams, Julien Sage, Jennifer R. Cochran   +6 more
doaj   +1 more source

Influence of oestradiol on exercise induced muscular damage and heart rate variability in a non‐trained healthy population

Experimental Physiology, EarlyView.
Abstract This study evaluates in non‐trained healthy women the influence of oestradiol (E2) on exercise induced muscular damage (EIMD) and performance. Thirty‐six young healthy women performed a step‐exercise until exhaustion, assessing the number of repetitions, pain perception and well‐being (questionnaires, 15 min and at 48 h post‐exercise), blood ...
David Ramiro‐Cortijo, Ricardo Alonso de Celada, Pilar Rodríguez‐Rodríguez, Stefanny Lozano Gutiérrez, Leonardo Betancourt, Santiago Ruvira, Silvia M. Arribas   +6 more
wiley   +1 more source

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury – a pilot study

Experimental Physiology, EarlyView.
Abstract Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face barriers to physical activity.
Sven P. Hoekstra, Christof A. Leicht, Dean Kellogg Jr., Yubo Wu, Terry Romo, Hannah Uhlig‐Reche, Michelle Trbovich   +6 more
wiley   +1 more source

Characterization of two putative cytokine receptors, gp130 and ciliary neurotrophic factor receptor, from terrestrial salamanders

Genes & Genetic Systems, 2011
Cytokines of the gp130 family are fundamental regulators of immune responses and signal through multimeric receptors to initiate intracellular second-messenger cascades. Here, we provide the first characterization of two full-length gp130 cytokine receptors from the cDNA of the red-legged salamander (Plethodon shermani).
Kiemnec-Tyburczy, Karen M., Watts, Richard A., Arnold, Stevan J.   +2 more
openaire   +3 more sources