Results 71 to 80 of about 11,604 (173)

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Cardiac Ablation of SOCS3 Aggravates DOCA-Salt-Induced Hypertrophic Remodeling by Activation of Gp130-Dependent Signaling in Mice

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cardiac remodeling is a critical pathogenetic process leading to heart failure. Suppressor of cytokine signaling-3 (SOCS3) is demonstrated as a key negative regulator of the gp130 receptor to inhibit cardiac hypertrophy.
Shuang Liu, Li-Xin Liu, Yun-Long Zhang, Song Lai, Yun-Peng Xie, Nan-Nan Li, Hong-Xia Wang, Yun-Long Xia, Ying Liu, Hui-Hua Li   +9 more
doaj   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, Volume 13, Issue 27, 13 May 2026.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro

Molecular Pain, 2011
Tenderness and mechanical allodynia are key symptoms of malignant tumor, inflammation and neuropathy. The proinflammatory cytokine interleukin-6 (IL-6) is causally involved in all three pathologies.
Constantin Cristina E, Vogl Christian, Quarta Serena, Üçeyler Nurcan, Sommer Claudia, Kress Michaela   +5 more
doaj   +1 more source

Interleukin‐6 and Oncostatin M Levels in Patients With Type 1 Diabetes and Its Relationship With Glycemic Indices

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
In children with type 1 diabetes, serum oncostatin M is significantly elevated and strongly predicts poor glycemic control, while IL‐6 is associated with diabetic ketoacidosis. OSM demonstrates high diagnostic accuracy, suggesting its potential as a sensitive biomarker for early detection and monitoring of paediatric T1DM.
Mona Nourbakhsh, Farzaneh Rouhani, Maryam Razzaghy‐Azar, Mitra Nourbakhsh, Vahid Saeedi, Mahdokht Mehramiz, Davoud Amirkashani, Arash Mohazzab, Taraneh Rezaee   +8 more
wiley   +1 more source

Investigating plasticity within the interleukin-6 family with AlphaFold-Multimer

Computational and Structural Biotechnology Journal
Cytokines are important soluble mediators that are involved in physiological and pathophysiological processes. Among them, members of the interleukin-6 (IL-6) family of cytokines have gained remarkable attention, because especially the name-giving ...
Stefan Düsterhöft, Johannes N. Greve, Christoph Garbers   +2 more
doaj   +1 more source

Increased expression of interleukin (IL)-6 family members and receptors in urinary bladder with cyclophosphamide (CYP)-induced bladder inflammation in female rats

Frontiers in Neuroscience, 2011
Recent studies suggest that JAK-STAT signaling pathways contribute to increased voiding frequency and referred pain of CYP-induced cystitis in rats. Potential upstream chemical mediator(s) that may be activated by CYP-induced cystitis to stimulate JAK ...
Beatrice eGirard, Bopaiah P Cheppudira, Susan eMalley, Kristin eSchutz, Victor eMay, Margaret A Vizzard   +5 more
doaj   +1 more source

Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study

European Journal of Histochemistry, 2020
Ciliary neurotrophic factor (CNTF) is a member of interleukin-6 type cytokine family. The CNTF receptor complex is a heterodimer including gp130 and CNTF receptor α (CNTFRα) proteins triggering the activation of multiple intracellular signaling pathways ...
Sonia Fantone, Giovanni Tossetta, Rodolfo Montironi, Martina Senzacqua , Daniela Marzioni, Roberta Mazzucchelli   +5 more
doaj   +1 more source

Molecular dynamics simulations reveal key roles of the LIF receptor in the assembly of human LIF signaling complex

Computational and Structural Biotechnology Journal
Leukemia inhibitory factor (LIF) is a critical cytokine involved in various biological processes, including stem cell self-renewal, inflammation, and cancer progression.
Bo Gao, Hanrui Liu, Mengkai Zhu, Shun Zhang, Meiniang Wang, Yijun Ruan, Yue Zheng   +6 more
doaj   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source