Results 81 to 90 of about 11,604 (173)

The Behaviour of IL-6 and Its Soluble Receptor Complex during Different Waves of the COVID-19 Pandemic

Life
In late December 2019, SARS-CoV-2 was identified as the cause of a new pneumonia (COVID-19), leading to a global pandemic declared by the WHO on 11 March 2020, with significant human, economic, and social costs.
Gaetano Di Spigna, Bianca Covelli, Maria Vargas, Roberta Di Caprio, Valentina Rubino, Carmine Iacovazzo, Filomena Napolitano, Giuseppe Servillo, Loredana Postiglione   +8 more
doaj   +1 more source

Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes

Nature Communications
Oncostatin M (OSM) is a unique Interleukin 6 (IL-6) family cytokine that plays pivotal roles in numerous biological events by signaling via two types of receptor complexes.
Yi Zhou, Panayiotis E. Stevis, Jing Cao, George Ehrlich, Jennifer Jones, Ashique Rafique, Mark W. Sleeman, William C. Olson, Matthew C. Franklin   +8 more
doaj   +1 more source

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Cell Reports, 2016
Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and ...
Niloufar Monhasery, Jens Moll, Carly Cuman, Manuel Franke, Larissa Lamertz, Rebecca Nitz, Boris Görg, Dieter Häussinger, Juliane Lokau, Doreen M. Floss, Roland Piekorz, Eva Dimitriadis, Christoph Garbers, Jürgen Scheller   +13 more
doaj   +1 more source

Cytokine-Dependent gp130 Receptor Subunit Regulates Rat Modified Axial-Pattern Epigastric Flap

Journal of Investigative Surgery, 2002
We investigated axial-pattern flap survival by modulating the cytokine receptor component, gp130, to elucidate the mechanism of the cytokine receptor modulation subsequently leading to the initiation of local angiogenesis and blood-flow augmentation. Fifty-two male Wistar rats were divided into four groups.
Sadanori, Akita, Mohammad Abdur, Rashid, Hiroshi, Ishihara, Takehiro, Daian, Seiji, Dazai, Tohru, Fujii   +5 more
openaire   +2 more sources

Selective loss of function variants in IL6ST cause Hyper-IgE syndrome with distinct impairments of T-cell phenotype and function

Haematologica, 2019
Hyper-IgE syndromes comprise a group of inborn errors of immunity. STAT3-deficient hyper-IgE syndrome is characterized by elevated serum IgE levels, recurrent infections and eczema, and characteristic skeletal anomalies.
Tala Shahin, Dominik Aschenbrenner, Deniz Cagdas, Sevgi Köstel Bal, Cecilia Domínguez Conde, Wojciech Garncarz, David Medgyesi, Tobias Schwerd, Betül Karaatmaca, Pınar Gur Cetinkaya, Saliha Esenboga, Stephen R. F. Twigg, Andrew Cant, Andrew O. M. Wilkie, Ilhan Tezcan, Holm H. Uhlig, Kaan Boztug   +16 more
doaj   +1 more source

Cytokines and their receptors in cardiovascular diseases — role of gp130 signalling pathway in cardiac myocyte growth and maintenance

International Journal of Experimental Pathology, 2000
Interleukin (IL)‐6‐related cytokines share gp130 as the signal‐transducing protein. Cardiac myocytes produce various kinds of cytokines including IL‐6 and cardiotrophin‐1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI‐3 kinase pathways.
K, Yamauchi-Takihara, T, Kishimoto
openaire   +3 more sources

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

EMBO Molecular Medicine, 2019
Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression.
Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand   +17 more
doaj   +1 more source

Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3

Molecular Therapy: Nucleic Acids, 2019
Interleukin-6 (IL-6)-type cytokines share the common receptor glycoprotein 130 (gp130), which activates a signaling cascade involving Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) transcription factors.
Florence A. Servais, Mélanie Kirchmeyer, Matthias Hamdorf, Nadège W.E. Minoungou, Stefan Rose-John, Stephanie Kreis, Claude Haan, Iris Behrmann   +7 more
doaj   +1 more source

Obesidad, inflamación e insulino-resistencia: papel de los ligandos del receptor gp 130

Anales del Sistema Sanitario de Navarra, 2008
La obesidad puede ser considerada como una patología inflamatoria crónica de bajo grado, caracterizada por una elevación de los niveles plasmáticos de citoquinas proinflamatorias como el factor de necrosis tumoral alfa (TNF-a), y proteínas reactantes de ...
B Marcos-Gómez, M Bustos, J Prieto, J.A Martínez, M.J Moreno-Aliaga   +4 more
doaj  

Unveiling novel insights into human IL-6 − IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis

Scientific Reports
The cytokine interleukin-6 (IL-6) plays a crucial role in autoimmune and inflammatory diseases. Understanding the precise mechanism of IL-6 interaction at the amino acid level is essential to develop IL-6-inhibiting compounds.
Kaitong Li, Junyu Cai, Zhiyang Jiang, Qingbin Meng, Zhao Meng, He Xiao, Guojiang Chen, Chunxia Qiao, Longlong Luo, Jijun Yu, Xinying Li, Yinxiang Wei, Hui Li, Chenghua Liu, Beifen Shen, Jing Wang, Jiannan Feng   +16 more
doaj   +1 more source