Results 1 to 10 of about 3,641,661 (311)

Evolution of JAK-STAT pathway components: mechanisms and role in immune system development.

PLoS ONE, 2012
BackgroundLying downstream of a myriad of cytokine receptors, the Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) pathway is pivotal for the development and function of the immune system, with additional important roles in ...
Clifford Liongue, Lynda A O'Sullivan, Monique C Trengove, Alister C Ward   +3 more
doaj   +1 more source

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

European Journal of Immunology, 2008
Recognition of microbial components by germ‐line encoded pattern recognition receptors (PRR) initiates immune responses to infectious agents. We and others have proposed that pairs or sets of PRR mediate host immunity.
K. Dennehy, G. Ferwerda, I. Faro-Trindade, E. Pyż, J. Willment, P. Taylor, Ann M. Kerrigan, S. Tsoni, S. Gordon, Friederike Meyer‐Wentrup, G. Adema, B. Kullberg, E. Schweighoffer, V. Tybulewicz, H. Mora-Montes, N. Gow, David L. Williams, M. Netea, Gordon D. Brown   +18 more
semanticscholar   +1 more source

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

eLife, 2017
Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia   +6 more
doaj   +1 more source

Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia

Scientific Reports, 2017
Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri, Csilla Szabó, Oguz Kelemen   +2 more
doaj   +1 more source

Trans-signaling by cytokine and growth factor receptors.

Cytokine & growth factor reviews, 1996
Although ligand-induced dimerization or oligomerization of receptors is a well established mechanism of growth factor signaling, increasing evidence indicates that biological responses are often mediated by receptor trans-signaling mechanisms involving ...
Alexander M. Castellino, Moses V. Chao
semanticscholar   +1 more source

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

eLife, 2019
Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes.
Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga   +12 more
doaj   +1 more source

Soluble cytokine receptors are present in normal human urine

Journal of Experimental Medicine, 1989
Affinity chromatography of crude human urinary proteins on either human rIL-6, human rIFN-gamma, or anti-IFN-gamma-R mAb yielded the two respective soluble receptors in significant quantities.
D. Novick, H. Engelmann, D. Wallach, Menachem Rubinstein   +3 more
semanticscholar   +1 more source

Proinflammatory cytokine production by adherent donor blood cells stimulated by soluble LPS and phagocyted bacteria

Инфекция и иммунитет
Specific stimulation of receptors of the innate immune system by their purified ligands is commonly used in basic studies of inflammation and in the development of anti-inflammatory drugs.
E. V. Lysakova, S. A. Rybtsov, Vladimir Yu. Toshchakov   +2 more
doaj   +1 more source

Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway

Molecular Pain, 2018
Background Neuropathic pain is observed in patients as chemotherapeutic oxaliplatin is used to treat metastatic digestive tumors; however, the mechanisms responsible for hyperalgesia are not well understood.
Dongsheng Xu, Hui Zhao, Han Gao, Huiling Zhao, Dandan Liu, Jing Li   +5 more
doaj   +1 more source

Five layers of receptor signalling in γδ T cell differentiation and activation

Frontiers in Immunology, 2015
The contributions of gamma-delta T cells to immunity to infection or tumours critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells.
Sérgio T. Ribeiro, Julie C. Ribot, Bruno eSilva-Santos   +2 more
doaj   +1 more source