Results 41 to 50 of about 3,641,661 (311)

TRAF Regulation of IL-17 Cytokine Signaling

Frontiers in Immunology, 2019
Tumor necrosis factor receptor (TNFR)-associated factors or (TRAFs) are important mediators of Interleukin-17 (IL-17) cytokine signaling and contribute to driving tissue responses that are crucial for protective immunity but are often implicated in ...
Shadi Swaidani, Shadi Swaidani, Caini Liu, Junjie Zhao, Katarzyna Bulek, Xiaoxia Li   +5 more
doaj   +1 more source

Differences in innate cytokine responses between European and African children. [PDF]

PLoS ONE, 2014
Although differences in immunological responses between populations have been found in terms of vaccine efficacy, immune responses to infections and prevalence of chronic inflammatory diseases, the mechanisms responsible for these differences are not ...
Lucja A Labuda, Sanne E de Jong, Lynn Meurs, Abena S Amoah, Moustapha Mbow, Ulysse Ateba-Ngoa, Alwin J van der Ham, André C Knulst, Maria Yazdanbakhsh, Ayola A Adegnika   +9 more
doaj   +1 more source

Cytokine production and signaling pathways in respiratory virus infection

Frontiers in Microbiology, 2013
It has been confirmed that respiratory virus infections can induce abberant cytokine production in the host. These cytokines may be associated with both elimination of the virus and complications in the host, such as virus-induced asthma.
Hirokazu eKimura, Masakazu eYoshizumi, Haruyuki eIshii, Kazunori eOishi, Akihide eRyo   +4 more
doaj   +1 more source

Protein Palmitoylation in Leukocyte Signaling and Function

Frontiers in Cell and Developmental Biology, 2020
Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent attachment of palmitate is reversibly and dynamically regulated by two opposing sets of ...
Xiaoyuan Yang, Victor Chatterjee, Yonggang Ma, Ethan Zheng, Sarah Y. Yuan, Sarah Y. Yuan   +5 more
doaj   +1 more source

Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors

Biosensors, 2020
Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19.
Eleonora Alfinito, Matteo Beccaria, Mariangela Ciccarese   +2 more
doaj   +1 more source

Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics

Communications Biology, 2022
Peptides composed of two or more tandemly linked macrocyclic peptides binding to growth factor/cytokine receptors (STaMPtides) are useful growth factor/cytokine mimetics.
Kenichiro Ito, Yoshihiko Matsuda, Ayako Mine, Natsuki Shikida, Kazutoshi Takahashi, Kyohei Miyairi, Kazutaka Shimbo, Yoshimi Kikuchi, Atsushi Konishi   +8 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Cytokines as cellular communicators

Mediators of Inflammation, 1996
Cytokines and their receptors are involved in the pathophysiology of many diseases. Here we present a detailed review on cytokines, receptors and signalling routes, and show that one important lesson from cytokine biology is the complex and diverse ...
R. Debets, H. F. J. Savelkoul
doaj   +1 more source

New insights into the immunomodulatory properties of poxvirus cytokine decoy receptors at the cell surface [version 1; referees: 2 approved]

F1000Research, 2018
Poxviruses encode a set of secreted proteins that bind cytokines and chemokines as a strategy to modulate host defense mechanisms. These viral proteins mimic the activity of host cytokine decoy receptors but have unique properties that may enhance their ...
Bruno Hernaez, Antonio Alcami
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source