Results 21 to 30 of about 3,641,661 (311)

Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors

iScience, 2021
Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner, Doreen Manuela Floss, Jürgen Scheller   +2 more
doaj   +1 more source

Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. [PDF]

PLoS ONE, 2011
Length and intensity of signal transduction via cytokine receptors is precisely regulated. Degradation of certain cytokine receptors is mediated by the ubiquitin ligase SCF(βTrCP).
Joyce Putters, Ana C da Silva Almeida, Peter van Kerkhof, Agnes G S H van Rossum, Ana Gracanin, Ger J Strous   +5 more
doaj   +1 more source

Multimerization strategies for efficient production and purification of highly active synthetic cytokine receptor ligands.

PLoS ONE, 2020
Cytokine signaling is transmitted by cell surface receptors which act as natural biological switches to control cellular functions such as immune reactions.
Sofie Mossner, Hoang T Phan, Saskia Triller, Jens M Moll, Udo Conrad, Jürgen Scheller   +5 more
doaj   +1 more source

Features of changes in the expression level of TNFα receptors and the functional response of cell lines upon stimulation with various doses of cytokine

Медицинская иммунология, 2023
TNFa is a pro-inflammatory cytokine that is signaled through type 1 (TNFR1) and type 2 (TNFR2) receptors. TNFR1 normally mediates apoptosis, cell survival, and cytokine secretion, while TNFR2 selectively mediates cell survival and cytokine secretion. But
Yu. A. Lopatnikova, Yu. V. Zhukova, A. A. Alshevskaya, I. A. Obleukhova, F. D. Kireev, I. A. Belomestnova, S. V. Sennikov   +6 more
doaj   +1 more source

Antibiotics regulate the immune response in both presence and absence of lipopolysaccharide through modulation of Toll-like receptors, cytokine production and phagocytosis in vitro.

International Immunopharmacology, 2014
The inflammatory response to pathogen-associated molecular patterns such as lipopolysaccharide (LPS) in sepsis is mediated via Toll-like receptors (TLRs).
C. Bode, B. Diedrich, S. Muenster, Viktoria Hentschel, C. Weisheit, K. Rommelsheim, A. Hoeft, R. Meyer, O. Boehm, P. Knuefermann, G. Baumgarten   +10 more
semanticscholar   +1 more source

Evolution of γ chain cytokines: Mechanisms, methods and applications

Computational and Structural Biotechnology Journal, 2022
The common γ chain family of cytokines and their receptors play fundamental roles in the immune system. Evolutionary studies of γ chain cytokines have elegantly illustrated how the immune system adapts to ever-changing environmental conditions.
Magdalena Antczak, Pablo F. Cañete, Zhian Chen, Clémence Belle, Di Yu   +4 more
doaj   +1 more source

Cytokine Decoy and Scavenger Receptors as Key Regulators of Immunity and Inflammation

Cytokine, 2016
IL-1R2 was the first decoy receptor to be described. Subsequently receptors which act as pure decoys or scavengers or trigger dampening of cytokine signaling have been described for cytokines and chemokines.
R. Bonecchi, C. Garlanda, A. Mantovani, F. Riva   +3 more
semanticscholar   +1 more source

Evolution of Class I cytokine receptors

BMC Evolutionary Biology, 2007
Background The Class I cytokine receptors have a wide range of actions, including a major role in the development and function of immune and blood cells. However, the evolution of the genes encoding them remains poorly understood. To address this we have
Ward Alister C, Liongue Clifford
doaj   +1 more source

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Science, 2020
Activated by interaction Cytokines trigger immune responses when they bind to their cognate receptors. Class I cytokine receptors rely on the associated Janus kinase 2 (JAK2) to initiate signal transduction.
S. Wilmes, S. Wilmes, M. Hafer, Joni Vuorio, J. Tucker, Hauke Winkelmann, Sara Löchte, T. Stanly, Katiuska Pulgar Prieto, C. Poojari, Vivek Sharma, C. Richter, Rainer Kurre, S. Hubbard, K. Garcia, Ignacio Moraga, I. Vattulainen, Ian S. Hitchcock, J. Piehler   +18 more
semanticscholar   +1 more source

Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K

Frontiers in Endocrinology, 2017
Type I and II cytokine receptors are cell surface sensors that bind cytokines in the extracellular environment and initiate intracellular signaling to control processes such as hematopoiesis, immune function, and cellular growth and development.
Lily Jun-shen Huang, Ping-hung Chen, Huiyu Yao   +2 more
doaj   +1 more source