Results 61 to 70 of about 11,604 (173)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis. [PDF]

PLoS Pathogens, 2013
Suppressor of cytokine signalling 3 (SOCS3) negatively regulates STAT3 activation in response to several cytokines such as those in the gp130-containing IL-6 receptor family. Thus, SOCS3 may play a major role in immune responses to pathogens.
Berit Carow, Ann-Kathrin Reuschl, Dolores Gavier-Widén, Brendan J Jenkins, Matthias Ernst, Akihiko Yoshimura, Benedict J Chambers, Martin E Rottenberg   +7 more
doaj   +1 more source

EPHX2 Orchestrates Intestinal Epithelial Barrier Repair in Ulcerative Colitis: An Integrated Multi‐Omics and Experimental Study

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
This study employed an integrated multi‐omics screening strategy incorporating GEO database differential expression analysis, GWAS‐eQTL genetic association analysis, and single‐cell RNA‐seq cell subpopulation localization to identify EPHX2 as a core causal gene in ulcerative colitis (UC).
Tian Dai, Siyu Han, Xiaoping Hu, Jiakuo Gu, Dongmei Liu, Jiale Wu, Juyan Zheng, Shiqin Hong, Yiwen Zhang   +8 more
wiley   +1 more source

Signal Transduction by a Cytokine Receptor: Multi-Scale Computational Studies of the Membrane Associated Gp130 Receptor Complex [PDF]

Biophysical Journal, 2013
Signal transduction is involved in the control of various essential biological processes such as cell growth, regeneration and apoptosis. Cytokines function as regulators of acute phase response during injury of infection, but are also involved in haematopoiesis, liver and neuronal regeneration.
Koldsø, Heidi, Sansom, Mark S.P.
openaire   +1 more source

Inflammatory cytokine IL‐6 regulates ADAMTS14 expression through MAPK and PI3K signaling in colorectal cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Interleukin‐6 induces ADAMTS14 expression in colorectal cancer cells. ADAMTS14 is transcriptionally regulated at the promoter level. Mitogen‐Activated Protein Kinase, Phosphatidylinositol 3‐Kinase, and Nuclear Factor Kappa B pathways mediate interleukin‐6‐induced ADAMTS14 expression.
Nelin Hacioglu, Rümeysa Nur Vapur Ondul, Ghufran Haqi Ismael, Feray Kockar   +3 more
wiley   +1 more source

Sequence analysis and modelling of the gp130 cytokines and receptors

, 2012
published_or_final_version ; Medical Sciences ; Master ; Master of Medical ...
openaire   +2 more sources

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes

Frontiers in Immunology, 2018
Interleukin (IL)-30, the IL-27p28 subunit of the heterodimeric cytokine IL-27, acts as an antagonist of IL-27 and IL-6 signaling in murine cells via glycoprotein 130 (gp130) receptor and additional binding partners.
Carlene Petes, Mélissa K. Mariani, Yawen Yang, Nathalie Grandvaux, Katrina Gee   +4 more
doaj   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

International Journal of Biological Sciences, 2012
Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in liver regeneration and in the metabolic control of the body.
Stefan Rose-John
doaj