Results 31 to 40 of about 18,703 (209)

Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice

Frontiers in Immunology, 2018
gp130 cytokines are differentially involved in regulating the T helper (H) 17-driven pathogenesis of experimental autoimmune encephalomyelitis (EAE), the animal model of human multiple sclerosis.
Kristian Holz, Marco Prinz, Marco Prinz, Stefanie M. Brendecke, Alexandra Hölscher, Fengyuan Deng, Hans-Willi Mitrücker, Stefan Rose-John, Stefan Rose-John, Christoph Hölscher, Christoph Hölscher, Christoph Hölscher   +11 more
doaj   +1 more source

Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and the JAK/STAT‐pathway,
Lukas Zanders, Melanie Kny, Alexander Hahn, Sibylle Schmidt, Sebastian Wundersitz, Mihail Todiras, Ines Lahmann, Arnab Bandyopadhyay, Tobias Wollersheim, Lars Kaderali, Friedrich C. Luft, Carmen Birchmeier, Steffen Weber‐Carstens, Jens Fielitz   +13 more
doaj   +1 more source

CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway

iScience, 2023
Summary: CD9 is a member of the tetraspanin protein family, which has been widely studied in inflammation and cancer, but not in pathological cardiac hypertrophy.
Yue Li, Siyuan Fan, Lingyao Kong, Zhenxuan Hao, Yanjun Zhou, Jiahong Shangguan, Lu Gao, Mingdan Wang, Yue Kang, Xiangrao Li, Kun Huang, Chao Zhang, Zhibo Liu   +12 more
doaj   +1 more source

Purification of synthetic GFP-Fc cytokine and simulation of IL-6 trans-signaling via GFP_VHH-gp130-SyCyRs.

, 2020
(A) Schematic illustration of IL-6 trans-signaling and a phenocopy using a synthetic receptor ligand system. The complex of IL-6 (dark green) and soluble IL-6R (blue) binds to two gp130 receptors (purple) and activates an intracellular signaling cascade.
Hoang T. Phan (8655357), Jens M. Moll (8655363), Jürgen Scheller (53995), Udo Conrad (575723), Sofie Mossner (8655354), Saskia Triller (8655360)   +5 more
core   +1 more source

Osteoclasts Are Present in gp130-Deficient Mice* [PDF]

Endocrinology, 1997
Interleukin (IL)-6, IL-11, leukemia inhibitory factor, and oncostatin M similarly induce osteoclast formation in cocultures of osteoblastic cells and bone marrow cells. These cytokines share a common signal transducer, gp130, which forms a receptor complex with the specific receptor for each cytokine.
K, Kawasaki, Y H, Gao, S, Yokose, Y, Kaji, T, Nakamura, T, Suda, K, Yoshida, T, Taga, T, Kishimoto, H, Kataoka, T, Yuasa, H, Norimatsu, A, Yamaguchi   +12 more
openaire   +2 more sources

Purification of synthetic mCherry-Fc cytokine and simulation of IL-6 trans-signaling via mCherry_VHH-gp130-SyCyR.

, 2020
(A) Schematic illustration of dimeric synthetic cytokine mCherry-Fc binding to two mCherryVHH-gp130-SyCyRs and thereby activating the signaling cascade. Images were created with BioRender.
Hoang T. Phan (8655357), Jens M. Moll (8655363), Jürgen Scheller (53995), Udo Conrad (575723), Sofie Mossner (8655354), Saskia Triller (8655360)   +5 more
core   +1 more source

Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer

Cancer Medicine, 2022
Background Nerve invasion (N‐inv) is an important prognostic factor in pancreatic ductal adenocarcinoma (PDAC). Elucidation of circulating N‐inv stimulators could provide deeper insights and novel perspectives for PDAC therapy.
Hidetaka Suzuki, Shuichi Mitsunaga, Masafumi Ikeda, Takao Aoyama, Kazumi Yoshizawa, Masayuki Yamaguchi, Masami Suzuki, Minoru Narita, Toshikatsu Kawasaki, Atsushi Ochiai   +9 more
doaj   +1 more source

Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells

Frontiers in Immunology, 2019
The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies have demonstrated ...
Khalid Bin Dhuban, Khalid Bin Dhuban, Khalid Bin Dhuban, Sabrina Bartolucci, Sabrina Bartolucci, Sabrina Bartolucci, Eva d'Hennezel, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo, Ciriaco A. Piccirillo   +9 more
doaj   +1 more source

Purification of synthetic GFP-mCherry-Fc and analysis of signal transduction induced through GFP_VHH-gp130 and mCherry_VHH-gp130 SyCyRs.

, 2020
(A) Schematic illustration of a GFP-mCherry fusion protein linked to the Fc domain of an IgG antibody. The Fc domain forms a dimer leading to a tetrameric assembly with two central mCherry proteins and GFP subunits on the outside.
Hoang T. Phan (8655357), Jens M. Moll (8655363), Jürgen Scheller (53995), Udo Conrad (575723), Sofie Mossner (8655354), Saskia Triller (8655360)   +5 more
core   +1 more source

Untersuchungen zur gp130/Jak1-Interaktion [PDF]

, 2000
The common receptor subunit gp130 is essential for cellular responses following stimulation with IL-6-type cytokines. Signal transduction via gp130 occurs through activation of constitutively associated kinases of the Janus family (Jak1, Jak2 and Tyk2 ...
Haan, Claude
core   +1 more source