Results 31 to 40 of about 17,335 (211)
Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy. [PDF]
PLoS ONE, 2017 Interleukins-6 (IL-6)/GP130 signaling pathway represents a promising target for cancer therapy due to its critical role in survival and progression of multiple types of cancer.
Hui Xiao +9 more
doaj +1 more source
Research in Cardiovascular Medicine, 2023 Context: Interleukin-6 (IL-6), a pro-inflammatory cytokine, plays an important role in the pathogenesis of myocardial hypertrophy. By integrating its membrane receptor complex (gp80), IL-6 activates the signal guidance components (gp130) and activates ...
Ahad Nikkholgh +3 more
doaj +1 more source
Roads to Stat3 Paved with Cadherins
Cells, 2022 The engagement of cadherins, cell-to-cell adhesion proteins, triggers a dramatic increase in the levels and activity of the Rac/Cdc42 GTPases, through the inhibition of proteasomal degradation.
Hanad Adan, Juliet Daniel, Leda Raptis
doaj +1 more source
Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]
, 2004 Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Kopp, F. B. +9 more
core +1 more source
GP130 Cytokines in Breast Cancer and Bone [PDF]
Cancers, 2020 Breast cancer cells have a high predilection for skeletal homing, where they may either induce osteolytic bone destruction or enter a latency period in which they remain quiescent. Breast cancer cells produce and encounter autocrine and paracrine cytokine signals in the bone microenvironment, which can influence their behavior in multiple ways.
Tolu Omokehinde, Rachelle W. Johnson
openaire +2 more sources
Osteoclasts Are Present in gp130-Deficient Mice* [PDF]
Endocrinology, 1997 Interleukin (IL)-6, IL-11, leukemia inhibitory factor, and oncostatin M similarly induce osteoclast formation in cocultures of osteoblastic cells and bone marrow cells. These cytokines share a common signal transducer, gp130, which forms a receptor complex with the specific receptor for each cytokine.
K, Kawasaki +12 more
openaire +2 more sources
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Sepsis and inflammation can cause intensive care unit‐acquired weakness (ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 signalling involves the glycoprotein 130 (gp130) receptor and the JAK/STAT‐pathway,
Lukas Zanders +13 more
doaj +1 more source
CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signaling pathway
iScience, 2023 Summary: CD9 is a member of the tetraspanin protein family, which has been widely studied in inflammation and cancer, but not in pathological cardiac hypertrophy.
Yue Li +12 more
doaj +1 more source
, 2020 (A) Schematic illustration of IL-6 trans-signaling and a phenocopy using a synthetic receptor ligand system. The complex of IL-6 (dark green) and soluble IL-6R (blue) binds to two gp130 receptors (purple) and activates an intracellular signaling cascade.
Hoang T. Phan (8655357) +5 more
core +1 more source
, 2020 (A) Schematic illustration of dimeric synthetic cytokine mCherry-Fc binding to two mCherryVHH-gp130-SyCyRs and thereby activating the signaling cascade. Images were created with BioRender.
Hoang T. Phan (8655357) +5 more
core +1 more source