Results 61 to 70 of about 17,335 (211)

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Biological activity of GFP³ and mCherry³ on gp130-SyCyR cells.

, 2020
(A) Proliferation of Ba/F3-gp130, Ba/F3-gp130-(GFPVHH-gp130) and Ba/F3-gp130-(mCherryVHH-gp130) cells without cytokine (-), in presence of 10 ng/ml Hyper-IL-6 or in presence of 100 ng/ml GFP3 or mCherry3.
Hoang T. Phan (8655357), Jens M. Moll (8655363), Jürgen Scheller (53995), Udo Conrad (575723), Sofie Mossner (8655354), Saskia Triller (8655360)   +5 more
core   +1 more source

Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes

eLife, 2020
Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals.
Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims   +7 more
doaj   +1 more source

Influence of oestradiol on exercise induced muscular damage and heart rate variability in a non‐trained healthy population

Experimental Physiology, EarlyView.
Abstract This study evaluates in non‐trained healthy women the influence of oestradiol (E2) on exercise induced muscular damage (EIMD) and performance. Thirty‐six young healthy women performed a step‐exercise until exhaustion, assessing the number of repetitions, pain perception and well‐being (questionnaires, 15 min and at 48 h post‐exercise), blood ...
David Ramiro‐Cortijo, Ricardo Alonso de Celada, Pilar Rodríguez‐Rodríguez, Stefanny Lozano Gutiérrez, Leonardo Betancourt, Santiago Ruvira, Silvia M. Arribas   +6 more
wiley   +1 more source

Langat virus inhibits the gp130/JAK/STAT signaling by reducing the gp130 protein level

Journal of Medical Virology
AbstractThe tick‐borne encephalitis virus (TBEV) serocomplex includes several medically important flavivirus members endemic to Europe, Asia, and North America, which can induce severe neuroinvasive or viscerotropic diseases with unclear mechanisms of pathogenesis.
Shaoli Lin, Xiaochun Wang, Bhargava Teja Sallapalli, Adam Hage, Peixi Chang, Jia He, Sonja M. Best, Yanjin Zhang   +7 more
openaire   +2 more sources

Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation

mAbs, 2022
The functional interleukin 6 (IL-6) signaling complex is a hexameric structure composed of IL-6, IL-6Rα, and the signaling receptor gp130. There are three different modes of IL-6 signaling, classic signaling, trans-signaling, and trans-presentation ...
Chun-Chi Chou, Kuo-Tai Hua, Min-Wei Chen, Chin-Jui Wu, Chun-Hua Hsu, Jann-Tay Wang, Michael Hsiao, Lin-Hung Wei   +7 more
doaj   +1 more source

Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling

Molecular Metabolism, 2021
Objective: Obesity is associated with low-grade adipose tissue inflammation and locally elevated levels of several glycoprotein 130 (gp130) cytokines.
Pim P. van Krieken, Timothy S. Odermatt, Marcela Borsigova, Matthias Blüher, Stephan Wueest, Daniel Konrad   +5 more
doaj   +1 more source

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury – a pilot study

Experimental Physiology, EarlyView.
Abstract Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face barriers to physical activity.
Sven P. Hoekstra, Christof A. Leicht, Dean Kellogg Jr., Yubo Wu, Terry Romo, Hannah Uhlig‐Reche, Michelle Trbovich   +6 more
wiley   +1 more source

A designer hyper interleukin 11 (H11) is a biologically active cytokine

BMC Biotechnology, 2012
Background Interleukin 11 (IL-11) is a pleiotropic cytokine with anti-apoptotic, anti-inflammatory and hematopoietic potential. The IL-11 activity is determined by the expression of the IL-11R receptor alpha (IL-11Rα) and the signal transducing subunit β
Dams-Kozlowska Hanna, Gryska Katarzyna, Kwiatkowska-Borowczyk Eliza, Izycki Dariusz, Rose-John Stefan, Mackiewicz Andrzej   +5 more
doaj   +1 more source

Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation

, 2009
Inflammation and vascular remodeling are hallmarks of atherosclerosis, hypertension, and restenosis after angioplasty. Here we investigated the role of the hepatocyte gp130-dependent systemic acute phase response on vascular remodeling after carotid ...
Salguero, Gustavo, Drexler, Helmut, Grote, Karsten, Schuett, Harald, Jagielska, Joanna, Schieffer, Bernhard, Müller, Werner; id_orcid, Tallone, Ezequiel, Luchtefeld, Maren, Schley, René   +9 more
core   +1 more source