Results 61 to 70 of about 18,703 (209)

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Blockade of interleukin-6 (IL-6) signaling in dedifferentiated liposarcoma (DDLPS) decreases mouse double minute 2 (MDM2) oncogenicity via alternative splicing.

PLoS ONE
Effective therapies for retroperitoneal (RP) dedifferentiated liposarcoma (DDLPS) remain unavailable. Loco-regional recurrence occurs in >80% of cases; 5-year disease-specific survival is only 20%. DDLPS is especially prevalent in the retroperitoneum and
Abeba Zewdu, Danielle Braggio, Gonzalo Lopez, Kara Batte, Safiya Khurshid, Fernanda Costas C de Faria, Hemant K Bid, David Koller, Lucia Casadei, Katherine J Ladner, David Wang, Valerie Grignol, O Hans Iwenofu, Dawn Chandler, Denis C Guttridge, Raphael E Pollock   +15 more
doaj   +1 more source

A designer hyper interleukin 11 (H11) is a biologically active cytokine

BMC Biotechnology, 2012
Background Interleukin 11 (IL-11) is a pleiotropic cytokine with anti-apoptotic, anti-inflammatory and hematopoietic potential. The IL-11 activity is determined by the expression of the IL-11R receptor alpha (IL-11Rα) and the signal transducing subunit β
Dams-Kozlowska Hanna, Gryska Katarzyna, Kwiatkowska-Borowczyk Eliza, Izycki Dariusz, Rose-John Stefan, Mackiewicz Andrzej   +5 more
doaj   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation

, 2009
Inflammation and vascular remodeling are hallmarks of atherosclerosis, hypertension, and restenosis after angioplasty. Here we investigated the role of the hepatocyte gp130-dependent systemic acute phase response on vascular remodeling after carotid ...
Salguero, Gustavo, Drexler, Helmut, Grote, Karsten, Schuett, Harald, Jagielska, Joanna, Schieffer, Bernhard, Müller, Werner; id_orcid, Tallone, Ezequiel, Luchtefeld, Maren, Schley, René   +9 more
core   +1 more source

Biological activity of GFP³ and mCherry³ on gp130-SyCyR cells.

, 2020
(A) Proliferation of Ba/F3-gp130, Ba/F3-gp130-(GFPVHH-gp130) and Ba/F3-gp130-(mCherryVHH-gp130) cells without cytokine (-), in presence of 10 ng/ml Hyper-IL-6 or in presence of 100 ng/ml GFP3 or mCherry3.
Hoang T. Phan (8655357), Jens M. Moll (8655363), Jürgen Scheller (53995), Udo Conrad (575723), Sofie Mossner (8655354), Saskia Triller (8655360)   +5 more
core   +1 more source

Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130 [PDF]

, 1998
The transmembrane protein gp130 is the common signalling receptor subunit for the interleukin-6 (IL-6)-type cytokines. It has recently been shown that the cytoplasmic domain of gp130 contains a dileucine internalization motif and that endocytosis of ...
Heinrich, P. C., Thiel, Stefan, Schaper, Fred, Gerhard Müller-Newen, Lutz Graeve, Martens, A., Dahmen, H., Stefan Thiel, Schaper, F., Graeve, L., Heinrich, Peter C., Martens, Astrid, Müller-Newen, Gerhard, Graeve, Lutz, Peter C. Heinrich, Müller-Newen, G., Heinrich, Peter, Thiel, S., Dahmen, Heike, Astrid Martens, Fred Schaper, Heike Dahmen   +21 more
core   +1 more source

The study of gp130/the inflammatory factors regulating osteoclast differentiation in rheumatoid arthritis

Biochemistry and Biophysics Reports, 2021
Rheumatoid arthritis (RA) is a chronic immune disease characterized by synovitis and bone destruction. The osteoclasts play a critical role in pathologic bone loss during inflammatory arthritis.
Renling Zou, Xiayang Huang, Peng Xu
doaj   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Elevated Maternal Soluble Gp130 and IL-6 Levels and Reduced Gp130 and SOCS-3 Expressions in Women Complicated With Preeclampsia

, 2011
Increased inflammatory response plays a significant role in the vascular pathophysiology in preeclampsia. However, the mechanism for increased inflammatory response in preeclampsia is largely unknown.
Shuang Zhao, Yang Gu, Lynn J. Groome, David F. Lewis, Yuping Wang   +4 more
core   +1 more source