Results 71 to 80 of about 29,459 (266)

IL-6/gp130 signaling: a key unlocking regeneration

Cell Regeneration, 2023
AbstractLiver is an organ with notable capacity of regeneration. Reprogramming of hepatocytes towards an immature state is one of the important mechanisms for hepatocyte replenishment. Inflammatory response mediated by IL-6 and its family cytokines has been widely reported closely related with tissue regeneration in myriads of organs.
Ruopu Li, Deqiang Li, Yu Nie
openaire   +3 more sources

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

A designer hyper interleukin 11 (H11) is a biologically active cytokine

BMC Biotechnology, 2012
Background Interleukin 11 (IL-11) is a pleiotropic cytokine with anti-apoptotic, anti-inflammatory and hematopoietic potential. The IL-11 activity is determined by the expression of the IL-11R receptor alpha (IL-11Rα) and the signal transducing subunit β
Dams-Kozlowska Hanna, Gryska Katarzyna, Kwiatkowska-Borowczyk Eliza, Izycki Dariusz, Rose-John Stefan, Mackiewicz Andrzej   +5 more
doaj   +1 more source

The study of gp130/the inflammatory factors regulating osteoclast differentiation in rheumatoid arthritis

Biochemistry and Biophysics Reports, 2021
Rheumatoid arthritis (RA) is a chronic immune disease characterized by synovitis and bone destruction. The osteoclasts play a critical role in pathologic bone loss during inflammatory arthritis.
Renling Zou, Xiayang Huang, Peng Xu
doaj   +1 more source

Effects of Methotrexate on IL-6alphar, VCAM-1 and NF Kappa B Expression in a Rat Model of Metabolic Syndrome [PDF]

, 2016
Background: In this study, we used Methotrexate (Mtx) to examine the role of immunomodulation on the activation of IL-6 and VCAM-1, which could generate a microenvironment that supports cardiovascular remodelling.Methods: Male WKY and SHR rats were ...
Diez, Emiliano Raúl, García, Rodrigo Damián, Miatello, Roberto Miguel, Ramirez, Jésica M., Renna, Nicolas Federico   +4 more
core   +1 more source

Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells

International Journal of Cancer, Volume 158, Issue 10, Page 2641-2649, 15 May 2026.
What's New? Exercise releases bioactive molecules into the bloodstream that can directly slow cancer cell growth. In colon cancer, this may help limit disease progression. Here, using colon cancer cells, the authors investigated the effects of exercise‐conditioned human serum on DNA repair mechanisms. Notably, acute exercise in humans elicited systemic
Samuel T. Orange, Emily Dodd, Sharanya Nath, Hannah Bowden, Alastair R. Jordan, Hannah Tweddle, Ann Hedley, Ifeoma Chukwuma, Ian Hickson, Sweta Sharma Saha   +9 more
wiley   +1 more source

Interleukin‐6 and Oncostatin M Levels in Patients With Type 1 Diabetes and Its Relationship With Glycemic Indices

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
In children with type 1 diabetes, serum oncostatin M is significantly elevated and strongly predicts poor glycemic control, while IL‐6 is associated with diabetic ketoacidosis. OSM demonstrates high diagnostic accuracy, suggesting its potential as a sensitive biomarker for early detection and monitoring of paediatric T1DM.
Mona Nourbakhsh, Farzaneh Rouhani, Maryam Razzaghy‐Azar, Mitra Nourbakhsh, Vahid Saeedi, Mahdokht Mehramiz, Davoud Amirkashani, Arash Mohazzab, Taraneh Rezaee   +8 more
wiley   +1 more source

Effect of carbohydrate feeding on the bone metabolic response to running [PDF]

, 2015
Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term bone metabolic responses
Craig Sale, Ian Varley, Jonathan C. Y. Tang, Julie P. Greeves, Peake JM, Ruth M. James, Thomas W. Jones, William D. Fraser, Zweig MH   +8 more
core   +1 more source

ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells

BMC Cancer
Colorectal cancer (CRC) is a worldwide health concern. Chronic inflammation is a risk factor for CRC, and interleukin-6 (IL-6) plays a pivotal role in this process.
Ting Lin, Shuxian Zhang, Yi Tang, Ming Xiao, Ming Li, Hanjuan Gong, Hailun Xie, Yalan Wang   +7 more
doaj   +1 more source

Co-Inhibition of tGLI1 and GP130 Using FDA-Approved Ketoconazole and Bazedoxifene Is Synergistic Against the Growth and Metastasis of HER2-Enriched and Triple-Negative Breast Cancers

Cells
Breast cancer stem cells (CSCs) are resistant to most cancer therapeutics and contribute to tumor recurrence and metastasis. Two breast CSC-promoting transcription factors, truncated glioma-associated oncogene homolog 1 (tGLI1) and signal transducer and ...
Sara Manore, Chuling Zhuang, Mariana K. Najjar, Grace L. Wong, Shivani Bindal, Kounosuke Watabe, Jiayuh Lin, Hui-Wen Lo   +7 more
doaj   +1 more source