Results 71 to 80 of about 18,703 (209)

ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells

BMC Cancer
Colorectal cancer (CRC) is a worldwide health concern. Chronic inflammation is a risk factor for CRC, and interleukin-6 (IL-6) plays a pivotal role in this process.
Ting Lin, Shuxian Zhang, Yi Tang, Ming Xiao, Ming Li, Hanjuan Gong, Hailun Xie, Yalan Wang   +7 more
doaj   +1 more source

Co-Inhibition of tGLI1 and GP130 Using FDA-Approved Ketoconazole and Bazedoxifene Is Synergistic Against the Growth and Metastasis of HER2-Enriched and Triple-Negative Breast Cancers

Cells
Breast cancer stem cells (CSCs) are resistant to most cancer therapeutics and contribute to tumor recurrence and metastasis. Two breast CSC-promoting transcription factors, truncated glioma-associated oncogene homolog 1 (tGLI1) and signal transducer and ...
Sara Manore, Chuling Zhuang, Mariana K. Najjar, Grace L. Wong, Shivani Bindal, Kounosuke Watabe, Jiayuh Lin, Hui-Wen Lo   +7 more
doaj   +1 more source

Interleukin-6 and insulin-like growth factor-1 synergistically promote the progression of NSCLC

Autoimmunity, 2018
The signaling pathways of interleukin-6 (IL-6) and insulin-like growth factor 1 (IGF-1) play an important role in the progression of lung cancer, and this study aimed to explore whether they can synergistically promote the progression of non-small cell ...
Hexiao Tang, Yuquan Bai, Gaofeng Pan, Xianguo Wang, Yanhong Wei, Zetian Yang, Jinping Zhao   +6 more
doaj   +1 more source

Langat virus inhibits the gp130/JAK/STAT signaling by reducing the gp130 protein level

Journal of Medical Virology
AbstractThe tick‐borne encephalitis virus (TBEV) serocomplex includes several medically important flavivirus members endemic to Europe, Asia, and North America, which can induce severe neuroinvasive or viscerotropic diseases with unclear mechanisms of pathogenesis.
Shaoli Lin, Xiaochun Wang, Bhargava Teja Sallapalli, Adam Hage, Peixi Chang, Jia He, Sonja M. Best, Yanjin Zhang   +7 more
openaire   +2 more sources

Lipotoxicity Amplifies IL‐6 Trans‐Signaling in Sinusoidal Endothelial Cells to Promote Endotheliopathy and Liver Injury

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects approximately 25% of the global population and is a major health concern. Liver sinusoidal endothelial cells (LSECs) undergo morphological and functional alterations during MASLD progression, resulting in endotheliopathy characterized by pro ...
Yasuhiko Ueda, Nao Kawaguchi, Yosuke Inomata, Jun Arima, Mitsuaki Ishida, Yuko Ito, Sang‐Woong Lee, Kohei Taniguchi   +7 more
wiley   +1 more source

Konstruktion und Charakterisierung eines konstitutiv aktiven Zytokin Rezeptors: gp130 [PDF]

, 2005
Cytokines are soluble proteins of low molecular weight which exert important functions via the regulation of intercellular communication in the immune and nervous system.
Lang, Sigrid
core   +1 more source

IL-6 Is Not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium tuberculosis H37rv

Cells, 2020
Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (
Kristina Ritter, Jan Christian Sodenkamp, Alexandra Hölscher, Jochen Behrends, Christoph Hölscher   +4 more
doaj   +1 more source

Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

Journal of Lipid Research, 2017
Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels.
Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhenwen Zhao, Junjie Zhang   +7 more
doaj   +1 more source

Passive heat therapy is feasible but does not affect cardiometabolic health outcomes in persons with spinal cord injury – a pilot study

Experimental Physiology, EarlyView.
Abstract Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face barriers to physical activity.
Sven P. Hoekstra, Christof A. Leicht, Dean Kellogg Jr., Yubo Wu, Terry Romo, Hannah Uhlig‐Reche, Michelle Trbovich   +6 more
wiley   +1 more source

Charakterisierung der Interaktion von gp130 und Jak1 [PDF]

, 2007
The subject of this dissertation is the interaction of gp130 and Jak1. Two aspects of this interaction were the main focus: Using FRAP (fluorescence recovery after photobleaching), it was demonstrated that there the kinase Jak1 has the same mobility as ...
Diefenbach, Sandra Christiane
core   +1 more source