Results 91 to 100 of about 18,703 (209)

gp130's sensitive side [PDF]

Science-Business eXchange, 2009
Medical University Innsbruck researchers suggest that inhibiting the gp130 pathway could help manage certain types of pain as well as exert a therapeutic effect in cancer and inflammation. The key will be to block the pathway without disrupting the body's natural immune response.
openaire   +1 more source

Glycoprotein (Gp130) Protein Expression During Mouse Skeletal Muscle Disuse Atrophy

, 2016
Physical inactivity, bed rest, and immobilization result in skeletal muscle disuse atrophy, which can negatively affect physical function and quality of life.
Patel, Hemani
core   +1 more source

The two facets of gp130 signalling in liver tumorigenesis

, 2021
The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers.
Galun, Eithan, Schmidt-Arras, Dirk, Rose-John, Stefan   +2 more
core   +1 more source

Ironing Out the Mechanism of gp130 Signaling

Pharmacological Reviews
gp130 functions as a shared signal-transducing subunit not only for interleukin (IL)-6 but also for eight other human cytokine receptor complexes. The IL-6 signaling pathway mediated through gp130 encompasses classical, trans, or cluster signaling, intricately regulated by a diverse array of modulators affecting IL-6, its receptor, and gp130. Currently,
Essam Eldin A. Osman, Nouri Neamati
openaire   +2 more sources

The gp130/STAT3-endoplasmic reticulum stress axis regulates hepatocyte necroptosis in acute liver injury

, 2023
Aim To investigate the effect of the gp130/STAT3-endoplasmic reticulum (ER) stress axis on hepatocyte necroptosis during acute liver injury. Methods ER stress and liver injury in LO2 cells were induced with thapsigargin, and in BALB/c mice with ...
Ying Li, Qi-Jiao Cheng, He, Yi-Huai, Cheng, Qi-Jiao, Liu, Xia, Wang, Jie, Xue Xiao, Zhi-Gang Jiang, Xia Li, Li, Ying, Yi-Huai He, Xiao, Xue, Jie Wang, Wei He, Xu, De-Lin, He, Wei, Li, Xia, Jiang, Zhi-Gang, Xia Liu, De-Lin Xu   +19 more
core   +1 more source

Bazedoxifene as a Potential Cancer Therapeutic Agent Targeting IL-6/GP130 Signaling

Current Oncology
Targeting the interleukin-6 (IL-6)/glycoprotein 130 (GP130) signaling pathway holds significant promise for cancer therapy given its essential role in the survival and progression of various cancer types.
Changyou Shi, Taylor Bopp, Hui-Wen Lo, Katherine Tkaczuk, Jiayuh Lin   +4 more
doaj   +1 more source

Glycoprotein 130 Cytokine Signal as a Therapeutic Target Against Cardiovascular Diseases

Journal of Pharmacological Sciences, 2011
.: Postnatal cardiomyocytes have only limited capacity of proliferation. Therefore, the myocardium is intrinsically equipped with cardioprotective machineries and protects itself from pathological stresses.
Yasushi Fujio, Makiko Maeda, Tomomi Mohri, Masanori Obana, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Hiroyuki Nakayama, Junichi Azuma   +8 more
doaj   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source

A gp130–Src–YAP module links inflammation to epithelial regeneration [PDF]

, 2015
Inflammation promotes regeneration of injured tissues through poorly understood mechanisms, some of which involve interleukin (IL)-6 family members, the expression of which is elevated in many diseases including inflammatory bowel diseases and colorectal
Boland, Brigid S, Karin, Michael, Sandborn, William J, Taniguchi, Koji, Fa-Xing Yu, Kepeng Wang, Koji Taniguchi, Yoshimura, Akihiko, Chang, John T, Kun-Liang Guan, Jessica Zucman-Rossi, Maehara, Yoshihiko, Zucman-Rossi, Jessica, Ho, Samuel B, Raz, Eyal, Michael Karin, Gary Hardiman, Yu, Fa-Xing, Petrus R. de Jong, Wu, Li-Wha, William J. Sandborn, Guan, Kun-Liang, Brigid S. Boland, de Jong, Petrus R, Sergei I. Grivennikov, Eyal Raz, Lian, Ian, Hardiman, Gary, Yoshihiko Maehara, Wang, Kepeng, Akihiko Yoshimura, John T. Chang, Samuel B. Ho, Grivennikov, Sergei I, Ian Lian, Li-Wha Wu   +35 more
core   +1 more source

Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer

Molecular Therapy: Nucleic Acids
The pro-inflammatory cytokine interleukin-6 (IL-6) via its IL-6 signal transducer (IL6ST/gp130) plays an important role in neuronal survival, neuro-regeneration, and pathological pain.
Theodora Kalpachidou, Kai Kummer, Valentina Handle, David Zimmermann, Maria Peteinareli, Serena Quarta, Natalia Mach, Laura Castaldi, Paul A. Heppenstall, Rainer V. Haberberger, Hermona Soreq, Michaela Kress   +11 more
doaj   +1 more source