Results 91 to 100 of about 17,335 (211)

Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation

, 2008
IL-6 is known to play a crucial role in the pathogenesis of chronic intestinal inflammation by modulating T cell functions. In this study, we investigated the role of gp130, the common signal transducer for all IL-6 cytokines, in a murine model of acute ...
Sander, Leif E., Streetz, Konrad L., Dierssen, Uta, Obermeier, Florian, Tacke, Frank, Singh, Anurag K., Müller, Werner; id_orcid, Lutz, Holger H., Trautwein, Christian, Seidler, Ursula, Kroy, Daniela C.   +10 more
core   +2 more sources

Increased expression of interleukin (IL)-6 family members and receptors in urinary bladder with cyclophosphamide (CYP)-induced bladder inflammation in female rats

Frontiers in Neuroscience, 2011
Recent studies suggest that JAK-STAT signaling pathways contribute to increased voiding frequency and referred pain of CYP-induced cystitis in rats. Potential upstream chemical mediator(s) that may be activated by CYP-induced cystitis to stimulate JAK ...
Beatrice eGirard, Bopaiah P Cheppudira, Susan eMalley, Kristin eSchutz, Victor eMay, Margaret A Vizzard   +5 more
doaj   +1 more source

Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130

, 1998
The transmembrane protein gp130 is the common signalling receptor subunit for the interleukin-6 (IL-6)-type cytokines. It has recently been shown that the cytoplasmic domain of gp130 contains a dileucine internalization motif and that endocytosis of ...
Heinrich, P. C., Thiel, Stefan, Schaper, Fred, Gerhard Müller-Newen, Lutz Graeve, Martens, A., Dahmen, H., Stefan Thiel, Schaper, F., Graeve, L., Heinrich, Peter C., Martens, Astrid, Müller-Newen, Gerhard, Graeve, Lutz, Peter C. Heinrich, Müller-Newen, G., Heinrich, Peter, Thiel, S., Dahmen, Heike, Astrid Martens, Fred Schaper, Heike Dahmen   +21 more
core   +1 more source

Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers

Cancer Science, Volume 117, Issue 5, Page 1209-1222, May 2026.
Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu, Mengzhu Chinn, Feng Chen, Yerkezhan Yerkinkazhina, Yuan Tian, Wei‐Guo Zhu   +5 more
wiley   +1 more source

Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R

Frontiers in Physiology, 2020
Background/AimHypertensive cardiac hypertrophy is the leading cause of cardiac remodeling and heart failure. We recently demonstrated that the immunoproteasome, an inducible form of the constitutive proteasome, plays a critical role in regulating ...
Wen Yan, Zhi-Chao Dong, Jing-Jing Wang, Yun-Long Zhang, Hong-Xia Wang, Bo Zhang, Hui-Hua Li   +6 more
doaj   +1 more source

Low 5HT1B and 5HT4 Receptor Neurotransmission as a Potential Link Between Cholesterol Metabolism and Suicide Risk

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Stress and inflammatory signals (e.g., IL‐6, TNFα, cortisol) may disrupt cholesterol metabolism and membrane microdomains known as lipid rafts. This can impair the function of serotonin receptors (5‐HT1B and 5‐HT4) that regulate impulsive behavior.
Hans O. Kalkman, Lukasz Smigielski
wiley   +1 more source

gp130's sensitive side [PDF]

Science-Business eXchange, 2009
Medical University Innsbruck researchers suggest that inhibiting the gp130 pathway could help manage certain types of pain as well as exert a therapeutic effect in cancer and inflammation. The key will be to block the pathway without disrupting the body's natural immune response.
openaire   +1 more source

Reduced expression of the cytokine transducer gp130 inhibits hormone secretion, cell growth, and tumor development of pituitary lactosomatotrophic GH3 cells [PDF]

, 2003
Two of the most potent cytokines that regulate anterior pituitary cell function are leukemia inhibitory factor and IL- 6. These and others like IL-11 and ciliary neurotrophic factor are referred to as the gp130 cytokines because they share the gp130 ...
Stalla, GK, Renner, U., Graciarena, M., Ken Kobayashi, Renner, U, Carolina Perez Castro, Páez-Pereda, M., Arzt, E, Giacomini, D., Marcelo Páez-Pereda, Günter K. Stalla, Arzt, E., Damiana Giacomini, Onofri, C., Onofri, C, Paez-Pereda, M, Chiara Onofri, Giacomini, D, Carbia Nagashima, A., Castro, CP, Alberto Carbia Nagashima, Eduardo Arzt, Graciarena, M, Nagashima, AC, Kobayashi, K., Mariana Graciarena, Kobayashi, K, Perez Castro, C., Ulrich Renner, Stalla, G.K.   +29 more
core   +1 more source

Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor

, 2022
Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signalling receptor glycoprotein 130 (gp130). The structural
Cecilia Emanuelsson, Christopher D. Bahl, Emanuelsson, Cecilia, Arturo Vera‐Rodriguez, Sibel Uzunçayır, Paulina Regenthal, Åbacka, Hannah, Karin Lindkvist‐Petersson, Bahl, Christopher D., Vera-Rodriguez, Arturo, Uzuncayir, Sibel, Regenthal, Paulina, Hannah Åbacka, Lindkvist-Petersson, Karin   +13 more
core   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source