Results 101 to 110 of about 29,459 (266)

Association of Polymorphisms in the Interleukin 6 Receptor Complex with Obesity and Hyperandrogenism [PDF]

, 2003
10 pages, 5 tables.Objective: Interleukin-6 (IL-6), is an inflammatory cytokine that may influence the pathogenesis of obesity and hyperandrogenism. IL-6 exerts its actions through a heterodimeric receptor consisting of two membrane-bound glycoproteins ...
Calvo, Rosa M., Escobar-Morreale, Héctor F., San Millán, José L., Sancho, José, Villuendas, Gemma   +4 more
core   +1 more source

Sex differences in IL‐6 responses to moderate‐intensity aerobic exercise are explained by cycling power output

Physiological Reports, Volume 14, Issue 7, April 2026.
Abstract This study characterized interleukin‐6 (IL‐6) and derivative‐reactive oxygen metabolites (d‐ROMs) responses to moderate‐intensity exercise in healthy adults and assessed whether sex differences were due to workload. Fifteen males (26.5 ± 2.9 years, BMI: 23.7 ± 3.1) and 14 females (25.7 ± 2.8 years, BMI: 21.2 ± 1.8 in the menstrual phase (MP ...
Ena Yoshida, Harumi Hayashida, Tung Lin Lu, Yasuhiro Seki, Katsuhiko Suzuki   +4 more
wiley   +1 more source

Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R

Frontiers in Physiology, 2020
Background/AimHypertensive cardiac hypertrophy is the leading cause of cardiac remodeling and heart failure. We recently demonstrated that the immunoproteasome, an inducible form of the constitutive proteasome, plays a critical role in regulating ...
Wen Yan, Zhi-Chao Dong, Jing-Jing Wang, Yun-Long Zhang, Hong-Xia Wang, Bo Zhang, Hui-Hua Li   +6 more
doaj   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Cell Reports, 2016
Interleukin (IL)-11 signaling is involved in various processes, including epithelial intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon binding of IL-11 to IL-11R1 or IL-11R2, two IL-11α-receptor splice variants, and ...
Niloufar Monhasery, Jens Moll, Carly Cuman, Manuel Franke, Larissa Lamertz, Rebecca Nitz, Boris Görg, Dieter Häussinger, Juliane Lokau, Doreen M. Floss, Roland Piekorz, Eva Dimitriadis, Christoph Garbers, Jürgen Scheller   +13 more
doaj   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice. [PDF]

, 2019
BackgroundThe mechanisms whereby neuroinflammation negatively affects neuronal function in the hypothalamus are not clear. Our previous study determined that obesity-mediated chronic inflammation elicits sex-specific impairment in reproductive function ...
Coss, Djurdjica, Lainez, Nancy M
core   +1 more source

Oncostatin m is produced in adipose tissue and is regulated in conditions of obesity and type 2 diabetes [PDF]

, 2013
CONTEXT: Adipose tissue is a highly active endocrine organ that secretes many factors that affect other tissues and whole-body metabolism. Adipocytes are responsive to several glycoprotein 130 (gp130) cytokines, some of which have been targeted as ...
Albasanz-Puig, Alessi, Anthony W. Ferrante, Balhoff, Blüher, Blüher, Brown, Carrie M. Elks, Celik, Crowe, David Sanchez-Infantes, Demyanets, Di Gregorio, Eric Ravussin, Ettinger, Fasnacht, Febbraio, Fried, Ghosh, Gloaguen, Hansen, Heinrich, Henkel, Hui, Jacqueline M. Stephens, Jeffrey M. Gimble, Kamiya, Kern, Komori, Lambert, Lehr, López, Miyaoka, Mohamed-Ali, Mosley, Nakamura, Natal, Okaya, Ouchi, Pradeep, Rega, Robert V. Considine, Ron F. Morrison, Rose, Rose, Rotter, Sleeman, Slevin, Song, Stephens, Suda, Tamura, Tenney, Ursula A. White, Virtue, Wahl, Wallace, Wallenius, Weisberg, White, White, Zarling, Zvonic, Zvonic   +63 more
core   +2 more sources

Inhibition of IL‐6/STAT3 Signaling by N‐Trans‐Hibiscusamide and Its Derivative in a Mouse Model of Collagen‐Induced Arthritis

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
The IL‐6/STAT3 axis is crucial in rheumatoid arthritis (RA) via Th17 differentiation. The IL‐6/STAT3 signaling pathway is downregulated as a result of the inhibition of IL‐6 and IL‐6R binding by NHA and NAD. NHA and NAD decrease the Th17 differentiation, which lessens the severity of CIA.
Hyung Jin Lim, Seon Gyeong Bak, Jaehoon Bae, Nisansala Chandimali, Eun Jae Park, Seung Woong Lee, Mingyeong Kim, Sang‐Hoon Lee, Yeong‐Seon Won, Sun Hee Cheong, Seung‐Jae Lee   +10 more
wiley   +1 more source

Ciliary neurotrophic factor (CNTF) plus soluble CNTF receptor α increases cyclooxygenase-2 expression, PGErelease and interferon-γ-induced CD40 in murine microglia [PDF]

, 2009
Background Ciliary neurotrophic factor (CNTF) has been regarded as a potent trophic factor for motor neurons. However, recent studies have shown that CNTF exerts effects on glial cells as well as neurons.
Hsiao-Wen Lin, Mohit Jain, Hong Li, Steven W Levison   +3 more
core   +1 more source