Results 101 to 110 of about 18,703 (209)

Intermittent Fasting‐Induced Orm2 Promotes Adipose Browning via the GP130/IL23R‐p38 Cascade

Advanced Science
Intermittent fasting (IF) plays a critical role in mitigating obesity, yet the precise biological mechanisms require further elucidation. Here Orosomucoid 2 (Orm2) is identified as an IF‐induced hepatokine that stimulates adipose browning.
Xuejuan Zhu, Xinran Wang, Jingang Wang, Lei Du, Zhen‐Ning Zhang, Donglei Zhou, Junfeng Han, Bing Luan   +7 more
doaj   +1 more source

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Nature Communications
IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses.
Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck   +8 more
doaj   +1 more source

Expression of gp130 in lung adenocarcinoma.

, 2014
肺癌目前是全球致死率最高的癌症。在台灣，肺癌目前位居國人癌症死亡率的首位，罹患人數也有逐年增加的趨勢。gp130 (glycoprotein 130)是穿透細胞膜接受器，幫助介白素-6 (interleukin-6)家族 (例如：IL-11, LIF, OSM, CNTF, and CT1)傳遞調控細胞生長、分化和發炎等的訊號。由於gp130在癌細胞中所扮演的角色目前仍不清楚。本研究中，藉由RT-PCR、西方墨點 (western blot)及免疫染色 (immunostaining)等技術 ...
曾郁潔, Tseng, Yu-Chieh
core  

Gp130 Orchestrates a Bidirectional Neuron-Microglia Circuit for neuroprotection

Acquired central nervous system (CNS) injury is one of the most common neurological conditions globally, yet effective treatment options are lacking. As the main tissue-resident macrophages of the CNS, microglia have emerged as key functional regulators ...
Juergen Scheller, Capucine Bianciotto, Hong Wa Lao, Mark Febbraio, Rohan Teasdale, Julia Ettich, Jana Vukovic, Emily F. Willis, Max Dierich, Duy Pham, Zhe Yang, Laura Grice, Samuel J. S. Stuart, Quan Nguyen, Frances Corrigan, Carl L Hooper, Stefan Rose-John, Marc J Ruitenberg, Yi Xu, Seung Jae Kim   +19 more
core   +1 more source

Fine mapping of heterozygous IL6ST nonsense variants underlying autosomal dominant hyper-IgE syndrome

JCI Insight
Loss-of-function (LOF) variants in IL6ST, encoding GP130, can cause hyper-IgE syndrome (HIES). Monoallelic LOF variants in IL6ST lead to HIES when located in the intracellular domain downstream of box 1/2 and upstream of the STAT3 phosphorylation sites ...
Kosuke Ashihara, Takaki Asano, Kanako Takeuchi, Kosuke Noma, Miyuki Tsumura, Wenjie Wang, Wei-Te Lei, Hisao Higo, Toshio Kubo, Yoko Mizoguchi, Shuhei Karakawa, Aurélie Cobat, Clément Conil, Etsushi Toyofuku, Akimasa Sekine, Kohsuke Imai, Dusan Bogunovic, Jean-Laurent Casanova, Cheng-Lung Ku, Vivien Béziat, Satoshi Okada   +20 more
doaj   +1 more source

Interleukin-6 family of cytokines and gp130 [PDF]

Blood, 1995
T, Kishimoto, S, Akira, M, Narazaki, T, Taga   +3 more
openaire   +2 more sources

Soluble gp130 Regulates Prostate Cancer Invasion and Progression in an Interleukin-6 Dependent and Independent Manner

, 2011
Purpose: Soluble gp130 is a regulator of interleukin-6/soluble interleukin-6 receptor signaling that influences prostate cancer progression. We determined the association of soluble gp130 with prostate cancer prognosis, invasiveness and epithelial-to ...
Hoefer Julia, Barbieri Christopher E., Karakiewicz Pierre I., Roehrborn Claus G., Scherr Douglas S., Culig Zoran, Chromecki Thomas F., MONTORSI , FRANCESCO, Cavarretta Ilaria T., Shariat Shahrokh F.   +9 more
core   +1 more source

GP130 Antagonism Enhances Porcine RV Function

Circulation Research
BACKGROUND: Right ventricular (RV) dysfunction is a risk factor for death in multiple cardiovascular diseases, but RV-enhancing therapies are lacking. Inhibition of GP130 (glycoprotein-130) signaling with the small molecule SC144 improves RV function in rodent RV dysfunction via anti-inflammatory and metabolic ...
Jenna B. Mendelson, Jacob D. Sternbach, Minwoo Kim, Ryan A. Moon, Lynn M. Hartweck, Sophia R. Clark, Walt Tollison, Matthew T. Lahti, John P. Carney, Todd Markowski, LeeAnn Higgins, Felipe Kazmirczak, Kurt W. Prins   +12 more
openaire   +2 more sources

细胞因子受体-抗人AFP嵌合抗体融合蛋白的构建及表达

四川大学学报. 自然科学版, 2008
用RT-PCR方法从人胎肝组织中扩增EpoR胞外区基因及gp130跨膜区基因,并用酶切连接方法将其与抗人AFP嵌合抗体拼接,连接到质粒pVITRO上,构建真核表达载体.将重组质粒转染CHO细胞,以RT-PCR、Western blot和ELISA方法检测融合蛋白的表达.结果显示稳定转染细胞株有约150kDa的融合蛋白表达.
吴静, 张平, 周昌华, 赵宗容, 魏大鹏, 章崇杰   +5 more
doaj  

Joined Signatures of Erythropoietin and Interleukin-6 Signaling by Synthetic Heterodimeric gp130:Epo Receptor Complexes. [PDF]

ACS Synth Biol
Schlei J, Franke KF, Holzmann D, Wittich C, Floss DM, Rafii P, Brors K, Scheller J.   +7 more
europepmc   +1 more source