Results 101 to 110 of about 17,335 (211)

Processing and release of endogenous immunogenic peptide signals

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY In both animals and plants, small secreted peptides known as cytokines and phytocytokines mediate local and systemic communication during immune and stress responses. These signaling molecules are typically synthesized as inactive precursors that require proteolytic processing to become active.
Maurice Koenig, Hermanyanto Laia, Gunther Doehlemann, Johana C. Misas Villamil   +3 more
wiley   +1 more source

Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet

Scientific Reports
Interleukin-6 (IL-6) is a major pro-inflammatory cytokine that demonstrates a robust correlation with age and body mass index (BMI) as part of the senescence-associated secretory phenotype. IL-6 cytokines also play a crucial role in metabolic homeostasis
Youngjoo Lee, Jade Tassey, Arijita Sarkar, Jonathan N. Levi, Siyoung Lee, Nancy Q. Liu, Andrew C. Drake, Falisha Nguyen, Jenny Magallanes, Una Stevic, Jinxiu Lu, Dawei Ge, Hanhan Tang, Tadiwanashe Mkaratigwa, Jichen Yang, Fangzhou Bian, Ruzanna Shkhyan, Michael A. Bonaguidi, Denis Evseenko   +18 more
doaj   +1 more source

GP130 cytokines and bone remodelling in health and disease

BMB Reports, 2010
Cytokines that bind to and signal through the gp130 co-receptor subunit include interleukin (IL)-6, IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), cardiotrophin-1 (CT-1), and ciliary neutrophic factor (CNTF). Apart from contributing to inflammation, gp130 signalling cytokines also function in the maintenance of bone homeostasis ...
Natalie A, Sims, Nicole C, Walsh
openaire   +3 more sources

Bazedoxifene as a Potential Cancer Therapeutic Agent Targeting IL-6/GP130 Signaling

Current Oncology
Targeting the interleukin-6 (IL-6)/glycoprotein 130 (GP130) signaling pathway holds significant promise for cancer therapy given its essential role in the survival and progression of various cancer types.
Changyou Shi, Taylor Bopp, Hui-Wen Lo, Katherine Tkaczuk, Jiayuh Lin   +4 more
doaj   +1 more source

Konstruktion und Charakterisierung eines konstitutiv aktiven Zytokin Rezeptors: gp130 [PDF]

, 2005
Cytokines are soluble proteins of low molecular weight which exert important functions via the regulation of intercellular communication in the immune and nervous system.
Lang, Sigrid
core  

Cytokine signalling via gp130 in gastric cancer

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Cytokine signalling pathways that depend on gp130 are dysregulated in several epithelial cancers including gastric cancer. It has been established that blockade of SHP2 activation of MAPK signalling results in hyperactivation of STAT3 resulting in increased cell proliferation, angiogenesis, inflammation and inhibition of both immunocyte and epithelial ...
Howlett, M., Menheniott, T.R., Judd, L.M., Giraud, A.S.   +3 more
openaire   +2 more sources

Glycoprotein 130 Cytokine Signal as a Therapeutic Target Against Cardiovascular Diseases

Journal of Pharmacological Sciences, 2011
.: Postnatal cardiomyocytes have only limited capacity of proliferation. Therefore, the myocardium is intrinsically equipped with cardioprotective machineries and protects itself from pathological stresses.
Yasushi Fujio, Makiko Maeda, Tomomi Mohri, Masanori Obana, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Hiroyuki Nakayama, Junichi Azuma   +8 more
doaj   +1 more source

Soluble gp130 Regulates Prostate Cancer Invasion and Progression in an Interleukin-6 Dependent and Independent Manner

, 2011
Purpose: Soluble gp130 is a regulator of interleukin-6/soluble interleukin-6 receptor signaling that influences prostate cancer progression. We determined the association of soluble gp130 with prostate cancer prognosis, invasiveness and epithelial-to ...
Hoefer Julia, Barbieri Christopher E., Karakiewicz Pierre I., Roehrborn Claus G., Scherr Douglas S., Culig Zoran, Chromecki Thomas F., MONTORSI , FRANCESCO, Cavarretta Ilaria T., Shariat Shahrokh F.   +9 more
core   +1 more source

Charakterisierung der Interaktion von gp130 und Jak1

, 2007
The subject of this dissertation is the interaction of gp130 and Jak1. Two aspects of this interaction were the main focus: Using FRAP (fluorescence recovery after photobleaching), it was demonstrated that there the kinase Jak1 has the same mobility as ...
Diefenbach, Sandra Christiane
core   +1 more source

Glycoprotein (Gp130) Protein Expression During Mouse Skeletal Muscle Disuse Atrophy

, 2016
Physical inactivity, bed rest, and immobilization result in skeletal muscle disuse atrophy, which can negatively affect physical function and quality of life.
Patel, Hemani
core