Results 81 to 90 of about 18,703 (209)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Identification of Prognostic Factors and Regulatory Pathways in Porto‐Sinusoidal Vascular Disorder

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background and Aims Porto‐sinusoidal vascular disorder (PSVD) is a rare liver condition characterized by specific histological features primarily affecting the hepatic sinusoidal and periportal vasculature, in the absence of cirrhosis. This study aimed to identify prognostic factors and regulatory pathways associated with PSVD by integrating ...
Subin Heo, Do Kyung Yoon, Soyeon Shin, Dami Youn, Youngeun Yoo, In Hye Song, Hyo Jeong Kang, Young‐In Yoon, Kyunggon Kim, Seung Soo Lee, Sung Won Chung, Jonggi Choi, Danbi Lee, Ju Hyun Shim, Kang Mo Kim, Young‐Suk Lim, Han Chu Lee, Mark Muthiah, Ho‐Su Lee, Won‐Mook Choi   +19 more
wiley   +1 more source

Increased expression of interleukin (IL)-6 family members and receptors in urinary bladder with cyclophosphamide (CYP)-induced bladder inflammation in female rats

Frontiers in Neuroscience, 2011
Recent studies suggest that JAK-STAT signaling pathways contribute to increased voiding frequency and referred pain of CYP-induced cystitis in rats. Potential upstream chemical mediator(s) that may be activated by CYP-induced cystitis to stimulate JAK ...
Beatrice eGirard, Bopaiah P Cheppudira, Susan eMalley, Kristin eSchutz, Victor eMay, Margaret A Vizzard   +5 more
doaj   +1 more source

Beyond the Heart‐Lung Axis: A Review of the Crosstalk Between the Hemodynamic, Neurohormonal, and Immune Systems in Pulmonary Hypertension

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Pulmonary hypertension is driven by dynamic crosstalk beyond the physical connection between the heart and lung, involving neurohormonal systems, immune pathways, and peripheral organs. This review highlights how multisystem signaling contributes to disease progression and may reveal new diagnostic and therapeutic targets.
Alejandro A. Vega, Juliet M. Alfaro, David S. Pinto, Maryam Emamimeybodi, Soban Umar   +4 more
wiley   +1 more source

Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R

Frontiers in Physiology, 2020
Background/AimHypertensive cardiac hypertrophy is the leading cause of cardiac remodeling and heart failure. We recently demonstrated that the immunoproteasome, an inducible form of the constitutive proteasome, plays a critical role in regulating ...
Wen Yan, Zhi-Chao Dong, Jing-Jing Wang, Yun-Long Zhang, Hong-Xia Wang, Bo Zhang, Hui-Hua Li   +6 more
doaj   +1 more source

Helicobacter pylori Outer Membrane Vesicles Engage TLR2 Through NapA to Promote Epithelial Association and Inflammatory Signalling

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
ABSTRACT Helicobacter pylori infection is characterized by chronic gastric inflammation driven by persistent activation of innate immune signalling pathways. Outer membrane vesicles (OMVs) released by H. pylori are important mediators of host–pathogen interactions. Although several mechanisms of OMV internalization have been described, how specific OMV‐
Mariaignacia Rubilar, Rosy Brito, Annegrett Palavecino, Joan Villena, Marco Mellado, María I. Silva, Manuel Valenzuela‐Valderrama   +6 more
wiley   +1 more source

Drug‐Induced Liver Injury During Treatment With Tocilizumab: A Case Report of an Atypical Pattern Lesion

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Tocilizumab is an interleukin‐6 (IL‐6) receptor antagonist indicated for various rheumatologic conditions. While hepatotoxicity is a recognized adverse effect, it predominantly manifests as hepatocellular injury. We report a rare case of drug‐induced liver injury (DILI) presenting with a cholestatic pattern and cholangitis features in a 75 ...
Louis‐Edmond Barbaro, Nouha Ben Othman, Delphine Viard, Fanny Rocher, Elliot Ewig, Raja Mroue, Claire Amigues, Alexandre O. Gérard   +7 more
wiley   +1 more source

Lack of gp130 expression in hepatocytes promotes liver injury

, 2003
Background & Aims; Interleukin 6 (IL-6) contributes via its signal transducer gp130 to the acute phase response (APR) in hepatocytes. Recent studies indicated that IL-6 is involved in the regulation of different pathophysiologic conditions of the ...
Klein, Christian, Schutz, Günther, Streetz, Konrad L., Betz, Ullrich A K, Wüstefeld, Torsten, Müller, Werner; id_orcid, Trautwein, Christian, Tronche, Francois, Manns, Michael P., Kallen, Karl Josef   +9 more
core   +1 more source

Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs

Aging Cell, Volume 25, Issue 10, October 2026.
Single‐cell transcriptomic profiling across multiple organs identifies aging reshapes neutrophil differentiation from the bone marrow to peripheral tissues. Computation analysis identifies an age‐enriched Neu06‐IL6 neutrophil state and predicts IL‐6 as one of a candidate regulator for neutrophil remodeling.
Yuman Wang, Teding Chang, Yangguang Fu, Guangyu Liang, Huicheng Liu, Le Zhang, Jinhua Yan, Man Liu, Anding Liu, Cuntai Zhang   +9 more
wiley   +1 more source

Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet

Scientific Reports
Interleukin-6 (IL-6) is a major pro-inflammatory cytokine that demonstrates a robust correlation with age and body mass index (BMI) as part of the senescence-associated secretory phenotype. IL-6 cytokines also play a crucial role in metabolic homeostasis
Youngjoo Lee, Jade Tassey, Arijita Sarkar, Jonathan N. Levi, Siyoung Lee, Nancy Q. Liu, Andrew C. Drake, Falisha Nguyen, Jenny Magallanes, Una Stevic, Jinxiu Lu, Dawei Ge, Hanhan Tang, Tadiwanashe Mkaratigwa, Jichen Yang, Fangzhou Bian, Ruzanna Shkhyan, Michael A. Bonaguidi, Denis Evseenko   +18 more
doaj   +1 more source