Results 81 to 90 of about 17,335 (211)

The gp130/STAT3-endoplasmic reticulum stress axis regulates hepatocyte necroptosis in acute liver injury

, 2023
Aim To investigate the effect of the gp130/STAT3-endoplasmic reticulum (ER) stress axis on hepatocyte necroptosis during acute liver injury. Methods ER stress and liver injury in LO2 cells were induced with thapsigargin, and in BALB/c mice with ...
Ying Li, Qi-Jiao Cheng, He, Yi-Huai, Cheng, Qi-Jiao, Liu, Xia, Wang, Jie, Xue Xiao, Zhi-Gang Jiang, Xia Li, Li, Ying, Yi-Huai He, Xiao, Xue, Jie Wang, Wei He, Xu, De-Lin, He, Wei, Li, Xia, Jiang, Zhi-Gang, Xia Liu, De-Lin Xu   +19 more
core   +1 more source

Exercise serum promotes DNA damage repair and remodels gene expression in colon cancer cells

International Journal of Cancer, Volume 158, Issue 10, Page 2641-2649, 15 May 2026.
What's New? Exercise releases bioactive molecules into the bloodstream that can directly slow cancer cell growth. In colon cancer, this may help limit disease progression. Here, using colon cancer cells, the authors investigated the effects of exercise‐conditioned human serum on DNA repair mechanisms. Notably, acute exercise in humans elicited systemic
Samuel T. Orange, Emily Dodd, Sharanya Nath, Hannah Bowden, Alastair R. Jordan, Hannah Tweddle, Ann Hedley, Ifeoma Chukwuma, Ian Hickson, Sweta Sharma Saha   +9 more
wiley   +1 more source

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Ironing Out the Mechanism of gp130 Signaling

Pharmacological Reviews
gp130 functions as a shared signal-transducing subunit not only for interleukin (IL)-6 but also for eight other human cytokine receptor complexes. The IL-6 signaling pathway mediated through gp130 encompasses classical, trans, or cluster signaling, intricately regulated by a diverse array of modulators affecting IL-6, its receptor, and gp130. Currently,
Essam Eldin A. Osman, Nouri Neamati
openaire   +2 more sources

Interleukin‐6 and Oncostatin M Levels in Patients With Type 1 Diabetes and Its Relationship With Glycemic Indices

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
In children with type 1 diabetes, serum oncostatin M is significantly elevated and strongly predicts poor glycemic control, while IL‐6 is associated with diabetic ketoacidosis. OSM demonstrates high diagnostic accuracy, suggesting its potential as a sensitive biomarker for early detection and monitoring of paediatric T1DM.
Mona Nourbakhsh, Farzaneh Rouhani, Maryam Razzaghy‐Azar, Mitra Nourbakhsh, Vahid Saeedi, Mahdokht Mehramiz, Davoud Amirkashani, Arash Mohazzab, Taraneh Rezaee   +8 more
wiley   +1 more source

Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity

Journal of Lipid Research, 2017
Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels.
Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhenwen Zhao, Junjie Zhang   +7 more
doaj   +1 more source

A gp130–Src–YAP module links inflammation to epithelial regeneration [PDF]

, 2015
Inflammation promotes regeneration of injured tissues through poorly understood mechanisms, some of which involve interleukin (IL)-6 family members, the expression of which is elevated in many diseases including inflammatory bowel diseases and colorectal
Boland, Brigid S, Karin, Michael, Sandborn, William J, Taniguchi, Koji, Fa-Xing Yu, Kepeng Wang, Koji Taniguchi, Yoshimura, Akihiko, Chang, John T, Kun-Liang Guan, Jessica Zucman-Rossi, Maehara, Yoshihiko, Zucman-Rossi, Jessica, Ho, Samuel B, Raz, Eyal, Michael Karin, Gary Hardiman, Yu, Fa-Xing, Petrus R. de Jong, Wu, Li-Wha, William J. Sandborn, Guan, Kun-Liang, Brigid S. Boland, de Jong, Petrus R, Sergei I. Grivennikov, Eyal Raz, Lian, Ian, Hardiman, Gary, Yoshihiko Maehara, Wang, Kepeng, Akihiko Yoshimura, John T. Chang, Samuel B. Ho, Grivennikov, Sergei I, Ian Lian, Li-Wha Wu   +35 more
core   +1 more source

Viral Mechanisms and Drug Influences on Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) Pathway in Human Coronaviruses Infection: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Caleb Koranteng Kwayisi‐Darkwah, Gabriel Atampugbire, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +7 more
wiley   +1 more source

Lack of gp130 expression in hepatocytes promotes liver injury

, 2003
Background & Aims; Interleukin 6 (IL-6) contributes via its signal transducer gp130 to the acute phase response (APR) in hepatocytes. Recent studies indicated that IL-6 is involved in the regulation of different pathophysiologic conditions of the ...
Klein, Christian, Schutz, Günther, Streetz, Konrad L., Betz, Ullrich A K, Wüstefeld, Torsten, Müller, Werner; id_orcid, Trautwein, Christian, Tronche, Francois, Manns, Michael P., Kallen, Karl Josef   +9 more
core   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source