Results 111 to 120 of about 29,459 (266)

Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet

Scientific Reports
Interleukin-6 (IL-6) is a major pro-inflammatory cytokine that demonstrates a robust correlation with age and body mass index (BMI) as part of the senescence-associated secretory phenotype. IL-6 cytokines also play a crucial role in metabolic homeostasis
Youngjoo Lee, Jade Tassey, Arijita Sarkar, Jonathan N. Levi, Siyoung Lee, Nancy Q. Liu, Andrew C. Drake, Falisha Nguyen, Jenny Magallanes, Una Stevic, Jinxiu Lu, Dawei Ge, Hanhan Tang, Tadiwanashe Mkaratigwa, Jichen Yang, Fangzhou Bian, Ruzanna Shkhyan, Michael A. Bonaguidi, Denis Evseenko   +18 more
doaj   +1 more source

Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation [PDF]

, 2023
Lisa Charlotte Heinig, Emily Valentina Madelaine Huth, Isabell Yan, Neele Schumacher, Mikołaj Nawrocki, Niels Christian Lory, Peter Bradtke, Tabea Bertram, Guido Rattay, Joanna Schmid, Samuel Huber, Thorsten Wiech, Dirk Schmidt‐Arras, Stefan Rose‐John, Hans‐Willi Mittrücker   +14 more
openalex   +1 more source

Glycoprotein 130 Cytokine Signal as a Therapeutic Target Against Cardiovascular Diseases

Journal of Pharmacological Sciences, 2011
.: Postnatal cardiomyocytes have only limited capacity of proliferation. Therefore, the myocardium is intrinsically equipped with cardioprotective machineries and protects itself from pathological stresses.
Yasushi Fujio, Makiko Maeda, Tomomi Mohri, Masanori Obana, Tomohiko Iwakura, Akiko Hayama, Tomomi Yamashita, Hiroyuki Nakayama, Junichi Azuma   +8 more
doaj   +1 more source

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features ...
Antal, Corina E, Atkins, Annette R, Becerra, Carlos R, Borazanci, Erkut, Collisson, Eric A, Dann, Amanda M, DelGiorno, Kathleen E, Donahue, Timothy R, Downes, Michael, Erikson, Galina, Evans, Ronald M, Fang, Linjing, Gao, Weina, Grandgenett, Paul M, Hollingsworth, Michael A, Huang, Peiwu, Hunter, Tony, Leblanc, Mathias, Liang, Gaoyang, Lowy, Andrew M, Lytle, Nikki K, Manor, Uri, Meisenhelder, Jill, Pawson, Tony, Reya, Tannishtha, Ridinger-Saison, Maya, Santisakultarm, Thom P, Scadeng, Miriam, Shi, Yu, Sun, Huaiyu, Terenziani, Elena, Tian, Ruijun, Umetsu, Sarah E, Von Hoff, Daniel D, Wahl, Geoffrey M, Woo, Gyunghwi, Xu, Ruilian, Yuan, Xiao   +37 more
core  

Obesidad, inflamación e insulino-resistencia: papel de los ligandos del receptor gp 130 [PDF]

, 2008
Obesity can be considered as a low grade inflammatory disease, characterized by increased plasma levels of proinflammatory cytokines such as tumoral necrosis factor-a (TNF-a), and acute phase reactant proteins like C-reactive protein.
Bustos, M. (Matilde), Marcos, B. (Beatriz), Martinez, J.A. (José Alfredo), Moreno-Aliaga, M. J. (María Jesús), Prieto, J. (Jesús)   +4 more
core  

Central Role of IL-6 Receptor Signal-Transducing Chain gp130 in Activation of L-Selectin Adhesion by Fever-Range Thermal Stress [PDF]

, 2004
Qing Chen, Wan-Chao Wang, Robert A. Bruce, Hong Li, David M. Schleider, Michael J. Mulbury, Mark D. Bain, Paul K. Wallace, Heinz Baumann, Sharon S. Evans   +9 more
openalex   +1 more source

C/EBP-δ Induction by gp130 Signaling [PDF]

, 2004
Anil K. Kamaraju, Sophie H. Adjalley, Peilin Zhang, Judith Chebath, Michel Revel   +4 more
openalex   +1 more source

A structural template for gp130-cytokine signaling assemblies

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2002
The gp130-cytokine system has been fertile ground for protein structure-function studies aimed at elucidating the basis of ligand recognition and receptor activation. A number of longstanding questions involve the mechanism of the stepwise assembly of the active signaling complexes, as well as the structure of the gp130-cytokine complexes.
Chow, Dar-chone, Brevnova, Lena, He, Xiao-lin, Martick, Monika M, Bankovich, Alex, Garcia, K.Christopher   +5 more
openaire   +2 more sources

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. [PDF]

, 2019
How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77-a marker of T cell antigen receptor (TCR) signaling-to identify antigen-activated CD4 T cells in the SKG mouse model ...
Ashouri, Judith F, Chen, Yiling, Cheng, Debra A, Hansen, Erik, Hsu, Lih-Yun, Lattanza, Lisa, Rychkov, Dmitry, Sirota, Marina, Weiss, Arthur, Yu, Steven, Zikherman, Julie   +10 more
core  

Intermittent Fasting‐Induced Orm2 Promotes Adipose Browning via the GP130/IL23R‐p38 Cascade

Advanced Science
Intermittent fasting (IF) plays a critical role in mitigating obesity, yet the precise biological mechanisms require further elucidation. Here Orosomucoid 2 (Orm2) is identified as an IF‐induced hepatokine that stimulates adipose browning.
Xuejuan Zhu, Xinran Wang, Jingang Wang, Lei Du, Zhen‐Ning Zhang, Donglei Zhou, Junfeng Han, Bing Luan   +7 more
doaj   +1 more source