Results 111 to 120 of about 17,335 (211)
Intermittent Fasting‐Induced Orm2 Promotes Adipose Browning via the GP130/IL23R‐p38 Cascade
Advanced ScienceIntermittent fasting (IF) plays a critical role in mitigating obesity, yet the precise biological mechanisms require further elucidation. Here Orosomucoid 2 (Orm2) is identified as an IF‐induced hepatokine that stimulates adipose browning.
Xuejuan Zhu +7 more
doaj +1 more source
Nature CommunicationsIL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses.
Scott Gardner +8 more
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Expression of gp130 in lung adenocarcinoma.
, 2014 肺癌目前是全球致死率最高的癌症。在台灣，肺癌目前位居國人癌症死亡率的首位，罹患人數也有逐年增加的趨勢。gp130 (glycoprotein 130)是穿透細胞膜接受器，幫助介白素-6 (interleukin-6)家族 (例如：IL-11, LIF, OSM, CNTF, and CT1)傳遞調控細胞生長、分化和發炎等的訊號。由於gp130在癌細胞中所扮演的角色目前仍不清楚。本研究中，藉由RT-PCR、西方墨點 (western blot)及免疫染色 (immunostaining)等技術 ...
曾郁潔, Tseng, Yu-Chieh
core
EMBO Molecular Medicine, 2019 Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression.
Pathum Thilakasiri +17 more
doaj +1 more source
Der Einfluss von gp130 auf die axonale Regeneration im ZNS
, 2015 Eine inflammatorische Stimulation (IS) wirkt neuroprotektiv und regenerationsfördernd auf retinale Ganglienzellen (RGZ) mit geschädigtem Axon. Interleukin-6 (IL-6), Leukemia inhibitory factor (LIF) und Ciliary neurotrophic factor (CNTF) sind essentielle ...
Büchsel, Martin
core +1 more source
Gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis
, 2011 gp130 is a common receptor chain for cytokines such as interleukin (IL)-27 and IL-6. During experimental tuberculosis (TB), IL-27 prevents optimal antimycobacterial protection and limits the pathological sequelae of chronic inflammation.
Christoph Hölscher +11 more
core +1 more source
Deregulated IL-6/gp130 signalling in lung cancer development
, 2017 Lung cancer is the most common and lethal form of cancer in Australia and worldwide, with lung adenocarcinoma (LAC) being the most common phenotype of lung cancer.
Gavin Brooks (370915)
core +1 more source
Interleukin-6 family of cytokines and gp130 [PDF]
Blood, 1995 T, Kishimoto +3 more
openaire +2 more sources
STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
, 2007 BBackground & Aims: Hepcidin is a peptide hormone that is central to the regulation of iron homeostasis. In response to interleukin 6 (IL-6), hepatocytes produce hepcidin that decreases iron release/transfer from enterocytes and macrophages and ...
Pietrangelo, Antonello +14 more
core +1 more source
四川大学学报. 自然科学版, 2008 用RT-PCR方法从人胎肝组织中扩增EpoR胞外区基因及gp130跨膜区基因,并用酶切连接方法将其与抗人AFP嵌合抗体拼接,连接到质粒pVITRO上,构建真核表达载体.将重组质粒转染CHO细胞,以RT-PCR、Western blot和ELISA方法检测融合蛋白的表达.结果显示稳定转染细胞株有约150kDa的融合蛋白表达.
吴静 +5 more
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