Results 121 to 130 of about 29,459 (266)

Inflammatory Response as a Mechanism of Perinatal Programming: Long-term Impact on Pulmonary and Renal Function? [PDF]

, 2012
RATIONALE: Temporal changes in the fetal environment, such as malnutrition and placental insufficiency induce intrauterine growth restriction (IUGR) and lead to a permanent changes of physiological processes later in life.
Alejandre Alcázar, Miguel Angel
core  

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Nature Communications
IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses.
Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck   +8 more
doaj   +1 more source

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

EMBO Molecular Medicine, 2019
Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in solid malignancies and promotes their progression.
Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar‐Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael DW Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand   +17 more
doaj   +1 more source

Structural insights into the assembly of gp130 family cytokine signaling complexes [PDF]

, 2022
Yi Zhou, Panayiotis E. Stevis, Jing Cao, Kei Saotome, Jiaxi Wu, Arielle Glatman Zaretsky, Sokol Haxhinasto, George D. Yancopoulos, Andrew Murphy, Mark W. Sleeman, William C. Olson, Matthew C. Franklin   +11 more
openalex   +1 more source

Supplementary Methods and Figure Legend from Discovery of a Novel Orally Active Small-Molecule gp130 Inhibitor for the Treatment of Ovarian Cancer

, 2023
Shili Xu, Fedora Grande, Antonio Garofalo, Nouri Neamati   +3 more
openalex   +1 more source

Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors [PDF]

, 1999
Annet Hammacher, John Wijdenes, Douglas J. Hilton, Nicos A. Nicola, Richard J. Simpson, Judith E. Layton   +5 more
openalex   +1 more source

Transmembrane Domain of gp130 Contributes to Intracellular Signal Transduction in Hepatic Cells [PDF]

, 1997
Hongkyun Kim, Heinz Baumann
openalex   +1 more source

Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.

, 1996
Yojiro Yamanaka, Koichi Nakajima, Toshiyuki Fukada, Masahiko Hibi, T Hirano   +4 more
openalex   +2 more sources

Assignment of the gene for gp130^RB13-6 (Pdnpno) to rat chromosome band 1p12 by in situ hybridization [PDF]

, 1996
Bernd Koelsch, S. Stadge, Heidrun L. Deissler, Manfred F. Rajewsky   +3 more
openalex   +1 more source

El Trypanosoma Cruzi, parásito que causa la enfermedad de Chagas, modula la señalización inducida por interleuquina-6 a través de la degradación de receptor gp130 en diferentes células de huesped [PDF]

, 2013
Interleuquina-6 es una citoquina pleiotrópica que participa en la respuesta inmune y en la sobrevida de las células a través de la activación del factor de transcripción STAT3 vía el receptor transductor de señales (gp)130.
Aoki, Maria del Pilar, Gea, Susana, Ponce, Nicolás Eric, Sanmarco, Liliana Maria   +3 more
core