Results 121 to 130 of about 17,335 (211)

The Evolution of IL6-IL6R-JAK-STAT Signaling Pathway in Metazoan. [PDF]

Biology (Basel)
Yu H, Chang R, Wang H, He M, Sun J, Song L.   +5 more
europepmc   +1 more source

Activation of gp130 signaling in T cells drives T(H)17-mediated multi-organ autoimmunity

The IL-6-gp130-STAT3 signaling axis is a major regulator of inflammation. Activating mutations in the gene encoding gp130 and germline gain-of-function mutations in STAT3 (STAT3(GOF)) are associated with multi-organ autoimmunity, severe morbidity, and ...
Quintanilla-Martinez, L., Liebig, S., Hsiao, H.J., Özerdem, C., Wartewig, T., Keller, U., Feske, S., Kühl, A., Kühl, A.A., Ramamoorthy, S., Holz, M., Wunderlich, F., Faletti, L., Lehmann, M., Schick, M., Solé-Boldo, L., Wunderlich, F.T., Glauben, R., Gonzalez-Menendez, I., Gosavi, S., Baumgartner, F., Bamopoulos, S., Horne, A., Singh, N., Gonzelez-Menendez, I., Bamopoulos, S.A., Demel, U., Hsiao, H., Ehl, S., Ruland, J., Rose-John, S., Haas, S., Boldo, L., Walther, W.   +33 more
core   +1 more source

The role of interleukin-6 in diabetic retinal disease: pathophysiology and therapeutic targeting. [PDF]

Front Immunol
Harlow REA, Rose-John S, Haskova Z, Fauser S, Mesquida M.   +4 more
europepmc   +1 more source

Nonspecific Inhibition of IL6 Family Cytokine Signalling by Soluble gp130

IL6 is a proinflammatory cytokine that binds to membrane-bound IL6 receptor (IL6R) or soluble IL6R to signal via gp130 in cis or trans, respectively.
Cook, Stuart A, Stuart A. Cook, Widjaja, Anissa A, Anissa A. Widjaja   +3 more
core   +1 more source

The Role of Leukemia Inhibitory Factor in Attenuating Skeletal Muscle Atrophy: Mechanisms to Exercise Interventions. [PDF]

Cells
Jiang N, Wang S, Zhang J, Jia D.
europepmc   +1 more source

Gαi1 and Gαi3 mediate IL-11-induced signal transduction and are potential therapeutic targets for LUAD. [PDF]

Cell Death Dis
Luo G, Hu W, Yang J, Lu Z, Cui Y, Zeng W, Ding H, Li Q, Chen Z, Tong X, Ding C, Xu C, Zhao J.   +12 more
europepmc   +1 more source

Chronic inflammation is associated with increased anxiety in the Cancer Disparities Research Network. [PDF]

Brain Behav Immun Health
Loomans-Kropp H, Das P, Beneby A, Gokun Y, Bao LY, Yang W, Cheng TD, Oliveri J, Elsaid M, Benzo R, Paskett E, Cancer Disparities Research Network Working Group.   +11 more
europepmc   +1 more source

A Novel Phosphoglucomutase-3 Gene Variant Causing Milder Phenotype in Two Families. [PDF]

J Clin Immunol
Gemici Karaaslan B, Benamar M, Ulas S, Aydemir S, Yesil G, Gezdirici A, Sari AA, Nepesov S, Cokugras H, Camcioglu Y, Ayaz A, Aydogmus C, Charbonnier LM, Chatila T, Kiykim A.   +14 more
europepmc   +1 more source

Skeletal muscle expression of the genes associated with glycoprotein 130 signaling in relation to obesity and insulin sensitivity. [PDF]

J Endocrinol Invest
Danowska M, Nikołajuk A, Strączkowski M.   +2 more
europepmc   +1 more source

Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation

, 2007
The signal transducer gp130 initiates cellular events started by induction of JAK kinases resulting in Ras/Erk-mediated signalling and activation of STAT transcription factors, particularly STAT3. Within the present studies the role of the Interleukin-6 (
Dierßen, Uta
core