Results 21 to 30 of about 469,928 (258)

Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Cell Reports Medicine, 2021
Summary: Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al.
Luke Y.C. Chen, Catherine M. Biggs, Shahin Jamal, Sophie Stukas, Cheryl L. Wellington, Mypinder S. Sekhon   +5 more
doaj   +1 more source

Increased expression of interleukin-6 gene in gastritis and gastric cancer [PDF]

Brazilian Journal of Medical and Biological Research
Helicobacter pylori (H. pylori) induces an intense inflammatory response, mediated by proinflammatory cytokines, including interleukin (IL)-6 and its membrane receptor (IL-6R), which activates important signaling pathways in the development of gastric ...
M.P. Santos, J.N. Pereira, R.W. Delabio, M.A.C. Smith, S.L.M. Payão, L.C. Carneiro, M.S. Barbosa, L.T. Rasmussen   +7 more
doaj   +2 more sources

Interleukin-6 signalling in health and disease [version 1; peer review: 3 approved]

F1000Research, 2020
Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 receptor, which is not signalling competent.
Stefan Rose-John
doaj   +1 more source

Serum level of soluble interleukin 6 receptor is a useful biomarker for identification of treatment‐resistant major depressive disorder

Neuropsychopharmacology Reports, 2020
Aim A substantial proportion of major depressive disorder patients are treatment‐resistant to antidepressant therapy, who require augmentation drugs, or other treatments including electroconvulsive therapy or transcranial magnetic stimulation ...
Katsuhiko Yamasaki, Tomonori Hasegawa, Masatoshi Takeda   +2 more
doaj   +1 more source

Role of Soluble Interleukin-6 Receptor With Interleukin-6 in Human Hematopoiesis

Hematology, 1997
A complex of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 has been shown to play some roles in human hematopoiesis. It activates gp130 signal to stimulate human erythroid, megakaryocytic and primitive hematopoietic progenitor cells, which express gp130 but not IL-6R, in the presence of c-Kit signal mediated by stem cell factor (SCF).
K, Tsuji, T, Nakahata
openaire   +2 more sources

Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men

Cell Reports Medicine, 2021
Summary: Lack of interleukin-6 (IL-6) leads to expansion of adipose tissue mass in rodents and humans. The exact underlying mechanisms have not been identified.
Beckey Trinh, Merel Peletier, Casper Simonsen, Peter Plomgaard, Kristian Karstoft, Bente Klarlund Pedersen, Gerrit van Hall, Helga Ellingsgaard   +7 more
doaj   +1 more source

Interleukin-6/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells

Stem Cell Research & Therapy, 2018
Background Interleukin-6 (IL-6) with IL-6 receptor (IL-6R) play an important role in the tissue regeneration in vivo, especially bone metabolism. Bone marrow -derived mesenchymal stem cells (BM-MSCs) are multipotent stromal cells, which are main origin ...
Zhongyu Xie, Su’an Tang, Guiwen Ye, Peng Wang, Jinteng Li, Wenjie Liu, Ming Li, Shan Wang, Xiaohua Wu, Shuizhong Cen, Guan Zheng, Mengjun Ma, Yanfeng Wu, Huiyong Shen   +13 more
doaj   +1 more source

Increased platelet content of SDF-1alpha is associated with worse prognosis in patients with pulmonary prterial hypertension

Platelets, 2019
Inflammatory processes and platelet activity play an important role in the pathophysiology of pulmonary arterial hypertension (PAH). Enhanced IL-6 signaling and higher concentration of stromal-derived factor alpha (SDF-1) have been previously shown to be
Remigiusz Kazimierczyk, Piotr Blaszczak, Małgorzata Jasiewicz, Małgorzata Knapp, Katarzyna Ptaszynska-Kopczynska, Bozena Sobkowicz, Ewa Waszkiewicz, Ryszard Grzywna, Wlodzimierz J. Musial, Karol A. Kaminski   +9 more
doaj   +1 more source

Donor genetic variants in interleukin-6 and interleukin-6 receptor associate with biopsy-proven rejection following kidney transplantation

Scientific Reports, 2021
Rejection after kidney transplantation remains an important cause of allograft failure that markedly impacts morbidity. Cytokines are a major player in rejection, and we, therefore, explored the impact of interleukin-6 (IL6) and IL-6 receptor (IL6R) gene
Felix Poppelaars, Mariana Gaya da Costa, Siawosh K. Eskandari, Jeffrey Damman, Marc A. Seelen   +4 more
doaj   +1 more source

Targeting IL-6 Receptor Signaling with Satralizumab in Thyroid Eye Disease: Design of the Phase 3 SatraGO-1 and SatraGO-2 Trials

Ophthalmology and Therapy
Introduction Thyroid eye disease (TED) is a rare, autoimmune, orbital inflammatory disorder that is disfiguring, debilitating, and potentially sight-threatening.
Daniel Ezra, Atif Collins, Zdenka Haskova, Thomas Kuenzel, Hiroaki Ida, Miriam Triyatni, Christopher Brittain, Oluwatobi Idowu   +7 more
doaj   +1 more source