Results 21 to 30 of about 467,392 (261)

Role of Soluble Interleukin-6 Receptor With Interleukin-6 in Human Hematopoiesis

Hematology, 1997
A complex of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 has been shown to play some roles in human hematopoiesis. It activates gp130 signal to stimulate human erythroid, megakaryocytic and primitive hematopoietic progenitor cells, which express gp130 but not IL-6R, in the presence of c-Kit signal mediated by stem cell factor (SCF).
K, Tsuji, T, Nakahata
openaire   +2 more sources

Increased expression of interleukin-6 gene in gastritis and gastric cancer [PDF]

Brazilian Journal of Medical and Biological Research
Helicobacter pylori (H. pylori) induces an intense inflammatory response, mediated by proinflammatory cytokines, including interleukin (IL)-6 and its membrane receptor (IL-6R), which activates important signaling pathways in the development of gastric ...
M.P. Santos, J.N. Pereira, R.W. Delabio, M.A.C. Smith, S.L.M. Payão, L.C. Carneiro, M.S. Barbosa, L.T. Rasmussen   +7 more
doaj   +2 more sources

Serum level of soluble interleukin 6 receptor is a useful biomarker for identification of treatment‐resistant major depressive disorder

Neuropsychopharmacology Reports, 2020
Aim A substantial proportion of major depressive disorder patients are treatment‐resistant to antidepressant therapy, who require augmentation drugs, or other treatments including electroconvulsive therapy or transcranial magnetic stimulation ...
Katsuhiko Yamasaki, Tomonori Hasegawa, Masatoshi Takeda   +2 more
doaj   +1 more source

Interleukin-6 signalling in health and disease [version 1; peer review: 3 approved]

F1000Research, 2020
Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 receptor, which is not signalling competent.
Stefan Rose-John
doaj   +1 more source

Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

Cell Reports Medicine, 2021
Summary: Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al.
Luke Y.C. Chen, Catherine M. Biggs, Shahin Jamal, Sophie Stukas, Cheryl L. Wellington, Mypinder S. Sekhon   +5 more
doaj   +1 more source

The effect of interleukin‐6 and the interleukin‐6 receptor on glucose transport in mouse skeletal muscle [PDF]

Experimental Physiology, 2009
Exercise results in an increase in interleukin‐6 (IL‐6), its receptor (IL‐6R) and skeletal muscle glucose transport. Interleukin‐6 has been found to have equivocal effects on glucose transport, with no studies, to our knowledge, investigating any potential role of IL‐6R.
Gray, S.R., Ratkevicius, A., Wackerhage, H., Coats, P., Nimmo, M.A.   +4 more
openaire   +4 more sources

Regulation of interleukin‐6 receptor expression by interleukin‐6 in human monocytes — a re‐examination [PDF]

FEBS Letters, 1994
We have studied the expression and regulation of the interleukin‐6 receptor (gp80) and its signal transducer gp13O in primary human blood monocytes. Here, we show that freshly isolated human monocytes express mRNAs for gp80 and gp130. In contrast to a previous report [(1989) FEBS Lett. 249, 27–30] we find that neither lipopolysaccharide nor interleukin‐
Schoester, Monika, Heinrich, Peter, Graeve, Lutz   +2 more
openaire   +3 more sources

Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men

Cell Reports Medicine, 2021
Summary: Lack of interleukin-6 (IL-6) leads to expansion of adipose tissue mass in rodents and humans. The exact underlying mechanisms have not been identified.
Beckey Trinh, Merel Peletier, Casper Simonsen, Peter Plomgaard, Kristian Karstoft, Bente Klarlund Pedersen, Gerrit van Hall, Helga Ellingsgaard   +7 more
doaj   +1 more source

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. [PDF]

Proceedings of the National Academy of Sciences, 1993
It has been reported that soluble interleukin (IL)-6 receptor (sIL-6R) is detected in the serum of healthy individuals and its level is increased in patients with multiple myeloma and human immunodeficiency virus infection. Although several reports have suggested that sIL-6R potentiates IL-6 action, its physiological role remains unclear. In this study,
T, Tamura, N, Udagawa, N, Takahashi, C, Miyaura, S, Tanaka, Y, Yamada, Y, Koishihara, Y, Ohsugi, K, Kumaki, T, Taga   +9 more
openaire   +2 more sources

Interleukin-6/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells

Stem Cell Research & Therapy, 2018
Background Interleukin-6 (IL-6) with IL-6 receptor (IL-6R) play an important role in the tissue regeneration in vivo, especially bone metabolism. Bone marrow -derived mesenchymal stem cells (BM-MSCs) are multipotent stromal cells, which are main origin ...
Zhongyu Xie, Su’an Tang, Guiwen Ye, Peng Wang, Jinteng Li, Wenjie Liu, Ming Li, Shan Wang, Xiaohua Wu, Shuizhong Cen, Guan Zheng, Mengjun Ma, Yanfeng Wu, Huiyong Shen   +13 more
doaj   +1 more source