Results 21 to 30 of about 11,093,344 (292)

Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain [PDF]

open access: yes, 2012
Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes.
Domschke, Katharina   +75 more
core   +2 more sources

Expression of Interleukin–6 and Interleukin-6 Receptor in Ovine Oocytes During In vitroMaturation

open access: yesJournal of Integrative Agriculture, 2012
To study the effects of interleukin-6 (IL-6) and its receptor (IL-6R) during in vitro maturation of ovine oocytes, the mRNA and protein expression levels of IL-6 and IL-6R, along with their localization, were examined during ovine oocytes maturation in ...
Xi-an ZHAO   +7 more
doaj   +1 more source

Relationship of Soluble Interleukin-6 Receptors With Asthma: A Mendelian Randomization Study

open access: yesFrontiers in Medicine, 2021
Purpose: Emerging evidence suggests a potential role of interleukin-6 pathways—trans-signaling with soluble interleukin-6 receptors—in the asthma pathobiology.
Yoshihiko Raita   +9 more
doaj   +1 more source

A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhood [PDF]

open access: yes, 2004
Background: The interleukin (IL) 4/IL13 pathway is involved in the regulation of IgE production associated with atopic diseases. Numerous polymorphisms have been identified in the coding region of the IL4 receptor alpha chain (IL4Ra) and previous ...
Kabesch, Michael   +7 more
core   +1 more source

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist : a Mendelian randomisation analysis [PDF]

open access: yes, 2015
Funded by: UK Medical Research Council, British Heart Foundation, UK National Institute for Health Research, National Institute for Health Research Cambridge Biomedical Research Centre, European Research Council, and European Commission Framework ...
D. F. Easton (7608179)   +874 more
core   +5 more sources

Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome

open access: yesCell Reports Medicine, 2021
Summary: Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al.
Luke Y.C. Chen   +5 more
doaj   +1 more source

Increased expression of interleukin-6 gene in gastritis and gastric cancer [PDF]

open access: yesBrazilian Journal of Medical and Biological Research
Helicobacter pylori (H. pylori) induces an intense inflammatory response, mediated by proinflammatory cytokines, including interleukin (IL)-6 and its membrane receptor (IL-6R), which activates important signaling pathways in the development of gastric ...
M.P. Santos   +7 more
doaj   +2 more sources

Interleukin-6 signalling in health and disease [version 1; peer review: 3 approved]

open access: yesF1000Research, 2020
Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 receptor, which is not signalling competent.
Stefan Rose-John
doaj   +1 more source

Serum level of soluble interleukin 6 receptor is a useful biomarker for identification of treatment‐resistant major depressive disorder

open access: yesNeuropsychopharmacology Reports, 2020
Aim A substantial proportion of major depressive disorder patients are treatment‐resistant to antidepressant therapy, who require augmentation drugs, or other treatments including electroconvulsive therapy or transcranial magnetic stimulation ...
Katsuhiko Yamasaki   +2 more
doaj   +1 more source

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]

open access: yes, 2012
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Bozinovski, S   +39 more
core   +1 more source

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