Results 41 to 50 of about 11,093,344 (292)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
The effect of exercise on plasma soluble IL-6 receptor concentration: a dichotomous response [PDF]
, 2010 The aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function.
Stevenson, Emma +6 more
core
Pharmacology Research & Perspectives, 2020 Background and Purpose In cardiovascular diseases, cardiac fibroblasts (CFs) participate in the myocardial inflammation by producing pro‐inflammatory cytokines, worsening the prognosis.
Shota Tanaka +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Regulation of interleukin‐6 receptor expression by interleukin‐6 in human monocytes — a re‐examination [PDF]
FEBS Letters, 1994 We have studied the expression and regulation of the interleukin‐6 receptor (gp80) and its signal transducer gp13O in primary human blood monocytes. Here, we show that freshly isolated human monocytes express mRNAs for gp80 and gp130. In contrast to a previous report [(1989) FEBS Lett. 249, 27–30] we find that neither lipopolysaccharide nor interleukin‐
Schoester, Monika +2 more
openaire +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]
, 2010 PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core +4 more sources
Functional and Morphological Improvement of Dystrophic Muscle by Interleukin 6 Receptor Blockade
EBioMedicine, 2015 The anti-inflammatory agents glucocorticoids (GC) are the only available treatment for Duchenne muscular dystrophy (DMD). However, long-term GC treatment causes muscle atrophy and wasting. Thus, targeting specific mediator of inflammatory response may be
Laura Pelosi +10 more
doaj +1 more source
Disease Activity Is More Associated with IL-1 Than with IL-6 in Patients with Rheumatoid Arthritis
Life, 2022 Interleukin-1 receptor antagonist (IL-1ra) concentration reflects and is proportional to IL-1 production. Both IL-1 and IL-6 are involved in the pathogenesis of rheumatoid arthritis (RA).
Cristina Almeida-Santiago +6 more
doaj +1 more source
The effect of interleukin‐6 and the interleukin‐6 receptor on glucose transport in mouse skeletal muscle [PDF]
Experimental Physiology, 2009 Exercise results in an increase in interleukin‐6 (IL‐6), its receptor (IL‐6R) and skeletal muscle glucose transport. Interleukin‐6 has been found to have equivocal effects on glucose transport, with no studies, to our knowledge, investigating any potential role of IL‐6R.
Gray, S.R. +4 more
openaire +4 more sources